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Volumn 16, Issue 9, 1998, Pages 2986-2999

Phase I trial of continuous infusion flavopiridol, a novel cyclin- dependent kinase inhibitor, in patients with refractory neoplasms

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL;

EID: 0031670668     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.9.2986     Document Type: Article
Times cited : (394)

References (42)
  • 2
    • 0030832842 scopus 로고    scopus 로고
    • The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets
    • Monks A, Scudiero D, Johnson G, et al: The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets. Anticancer Drug Des 12:533-541, 1997
    • (1997) Anticancer Drug des , vol.12 , pp. 533-541
    • Monks, A.1    Scudiero, D.2    Johnson, G.3
  • 3
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell LH, Kastan MB: Cell cycle control and cancer. Science 266:1821-1828, 1994
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 4
    • 0030044817 scopus 로고    scopus 로고
    • CDK inhibitors in development and cancer
    • Harper J, Elledge S: CDK inhibitors in development and cancer. Curr Opin Genet Dev 6:56-64, 1996
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 56-64
    • Harper, J.1    Elledge, S.2
  • 5
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO: Principles of CDK regulation. Nature 374:131-134, 1995
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 6
    • 0029000579 scopus 로고
    • Cyclins and cyclin-dependent kinases: A biochemical view
    • Pines J: Cyclins and cyclin-dependent kinases: A biochemical view. Biochem J 308:697-711, 1995
    • (1995) Biochem J , vol.308 , pp. 697-711
    • Pines, J.1
  • 7
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 274:1672-1677, 1996
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 8
    • 0028991396 scopus 로고
    • Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia
    • Cordon-Cardo C: Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol 147:545-560, 1995
    • (1995) Am J Pathol , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 9
    • 0345654028 scopus 로고    scopus 로고
    • Chemical cyclin-dependent kinase inhibitors: Therapeutic implications
    • Gutkind JS (ed): Totowa, NJ, The Humana Press, Inc, (in press)
    • Sausville EA, Senderowicz AM: Chemical cyclin-dependent kinase inhibitors: Therapeutic implications, in Gutkind JS (ed): Signal Transduction, Cell Cycle and Their Inhibitors. Totowa, NJ, The Humana Press, Inc, 1998 (in press)
    • (1998) Signal Transduction, Cell Cycle and Their Inhibitors
    • Sausville, E.A.1    Senderowicz, A.M.2
  • 10
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy
    • Sedlacek HH, Czech J, Naik R, et al: Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy. Int J Oncol 9:1143-1168, 1996
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.H.1    Czech, J.2    Naik, R.3
  • 11
    • 0026452974 scopus 로고
    • Growth inhibition with reversible cell-cycle arrest of carcinoma cells by flavone L86-8275
    • Kaur G, Stetler-Stevenson M, Sebers S, et al: Growth inhibition with reversible cell-cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 84:1736-1740, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1736-1740
    • Kaur, G.1    Stetler-Stevenson, M.2    Sebers, S.3
  • 12
    • 0027433237 scopus 로고
    • Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity
    • Worland PJ, Kaur G, Stetler-Stevenson M, et al: Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem Pharmacol 46:1831-1840, 1993
    • (1993) Biochem Pharmacol , vol.46 , pp. 1831-1840
    • Worland, P.J.1    Kaur, G.2    Stetler-Stevenson, M.3
  • 13
    • 0028176485 scopus 로고
    • Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275
    • Losiewicz MD, Carlson BA, Kaur G, et al: Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Commun 201:589-595, 1994
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 589-595
    • Losiewicz, M.D.1    Carlson, B.A.2    Kaur, G.3
  • 14
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
    • Carlson BA, Dubay MM, Sausville EA, et al: Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 56:2973-2978, 1996
    • (1996) Cancer Res , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3
  • 15
    • 0029993339 scopus 로고    scopus 로고
    • Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
    • De Azevedo WF Jr, Mueller-Dieckmann HJ, Schulze-Gahmen U, et al: Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci U S A 93:2735-2740, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2735-2740
    • De Azevedo W.F., Jr.1    Mueller-Dieckmann, H.J.2    Schulze-Gahmen, U.3
  • 16
    • 0031963058 scopus 로고    scopus 로고
    • Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
    • Parker B, Kaur G, Nieves-Neira W, et al: Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 91:458-465, 1998
    • (1998) Blood , vol.91 , pp. 458-465
    • Parker, B.1    Kaur, G.2    Nieves-Neira, W.3
  • 17
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human and leukemia xenografts
    • Arguello F, Alexander M, Sterry J, et al: Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human and leukemia xenografts. Blood 91:2482-2490, 1998
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1    Alexander, M.2    Sterry, J.3
  • 18
    • 0031019034 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
    • Drees M, Dengler W, Roth T, et al: Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin Cancer Res 32:273-279, 1997
    • (1997) Clin Cancer Res , vol.32 , pp. 273-279
    • Drees, M.1    Dengler, W.2    Roth, T.3
  • 20
    • 85038544498 scopus 로고    scopus 로고
    • Determination of flavopiridol (L86-8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection
    • in press
    • Stinson S, Hill K, Siford T, et al: Determination of flavopiridol (L86-8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection. Cancer Chemother Pharmacol (in press)
    • Cancer Chemother Pharmacol
    • Stinson, S.1    Hill, K.2    Siford, T.3
  • 22
    • 0029027208 scopus 로고
    • New aspects of the pathophysiology and treatment of secretory diarrhea
    • Hansen MB, Skadhauge E: New aspects of the pathophysiology and treatment of secretory diarrhea. Physiol Res 44:61-78, 1995
    • (1995) Physiol Res , vol.44 , pp. 61-78
    • Hansen, M.B.1    Skadhauge, E.2
  • 23
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients
    • Abigerges D, Chabot GG, Armand JP, et al: Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients. J Clin Oncol 13:210-221, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3
  • 24
    • 0000115517 scopus 로고    scopus 로고
    • A novel chemotherapeutic agent, flavopiridol, modulates intestinal epithelial chloride secretion
    • abstr
    • Shenfeld M, Senderowicz AM, Sausville EA, et al: A novel chemotherapeutic agent, flavopiridol, modulates intestinal epithelial chloride secretion. Gastroenterology 112:404, 1997 (abstr)
    • (1997) Gastroenterology , vol.112 , pp. 404
    • Shenfeld, M.1    Senderowicz, A.M.2    Sausville, E.A.3
  • 25
    • 0029086997 scopus 로고
    • Consensus statement: Octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel
    • Harris AG, Odorisio TM, Woltering EA, et al: Consensus statement: Octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. Dig Dis Sci 40:1464-1473, 1995
    • (1995) Dig Dis Sci , vol.40 , pp. 1464-1473
    • Harris, A.G.1    Odorisio, T.M.2    Woltering, E.A.3
  • 26
    • 0031022872 scopus 로고    scopus 로고
    • Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (Kayexalate) in sorbitol: An underrecognized condition
    • Rashid A, Hamilton SR: Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (Kayexalate) in sorbitol: An underrecognized condition. Am J Surg Pathol 21:60-69, 1997
    • (1997) Am J Surg Pathol , vol.21 , pp. 60-69
    • Rashid, A.1    Hamilton, S.R.2
  • 27
    • 0028206673 scopus 로고
    • Sudden hearing loss associated with interferon
    • Kanda Y, Shigeno K, Kinoshita N, et al: Sudden hearing loss associated with interferon. Lancet 343:1134-1135, 1994
    • (1994) Lancet , vol.343 , pp. 1134-1135
    • Kanda, Y.1    Shigeno, K.2    Kinoshita, N.3
  • 28
    • 0021245539 scopus 로고
    • Peripheral sensory neuropathy and cisplatin chemotherapy
    • Roelofs RI, Hrushesky W, Rogin J, et al: Peripheral sensory neuropathy and cisplatin chemotherapy. Neurology 34:934-938, 1984
    • (1984) Neurology , vol.34 , pp. 934-938
    • Roelofs, R.I.1    Hrushesky, W.2    Rogin, J.3
  • 29
  • 30
    • 0025799688 scopus 로고
    • Flavone acetic acid: Is vascular shutdown the crucial mechanism of action?
    • Bibby MC, Double JA, Phillips RM, et al: Flavone acetic acid: Is vascular shutdown the crucial mechanism of action? Int J Radiat Biol 60:395-399, 1991
    • (1991) Int J Radiat Biol , vol.60 , pp. 395-399
    • Bibby, M.C.1    Double, J.A.2    Phillips, R.M.3
  • 31
    • 0023712232 scopus 로고
    • Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512)
    • Weiss RB, Greene RF, Knight RD, et al: Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512). Cancer Res 48:5878-5882, 1988
    • (1988) Cancer Res , vol.48 , pp. 5878-5882
    • Weiss, R.B.1    Greene, R.F.2    Knight, R.D.3
  • 32
    • 0026426158 scopus 로고
    • Phase I clinical and pharmacokinetic trial of flavone acetic acid
    • Havlin KA, Kuhn JG, Craig JB, et al: Phase I clinical and pharmacokinetic trial of flavone acetic acid. J Natl Cancer Inst 83:124-128, 1991
    • (1991) J Natl Cancer Inst , vol.83 , pp. 124-128
    • Havlin, K.A.1    Kuhn, J.G.2    Craig, J.B.3
  • 33
    • 0029999052 scopus 로고    scopus 로고
    • Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • Ferry RF, Smith A, Malkandi J, et al: Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2:659-668, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 659-668
    • Ferry, R.F.1    Smith, A.2    Malkandi, J.3
  • 34
    • 0025239010 scopus 로고
    • Enhancement of the antiproliferative activity of cis-diaminedichloroplatinun (II) (CDDP) by quercetin
    • Hoffmann J, Fiebig H, Winterhalter B, et al: Enhancement of the antiproliferative activity of cis-diaminedichloroplatinun (II) (CDDP) by quercetin. Int J Cancer 45:536-539, 1990
    • (1990) Int J Cancer , vol.45 , pp. 536-539
    • Hoffmann, J.1    Fiebig, H.2    Winterhalter, B.3
  • 35
    • 0018411349 scopus 로고
    • Immunosuppressive and anti-inflammatory effects of glucocorticoids
    • Baxler JD, Rousseau GG (eds): New York, NY, Springer Verlag
    • Fauci AS: Immunosuppressive and anti-inflammatory effects of glucocorticoids, in Baxler JD, Rousseau GG (eds): Glucocorticoid Hormone Action. New York, NY, Springer Verlag, 1979, pp 449-465
    • (1979) Glucocorticoid Hormone Action , pp. 449-465
    • Fauci, A.S.1
  • 36
    • 0021170937 scopus 로고
    • Effects on human peripheral lymphocytes of in vivo administration of 9-β-D arabino furanosyl-2-fluoradenine 5′-monophosphate (NSC 312887), a new purine antimetabolite
    • Boldt DH, Von Hoff DD, Kuhn JG, et al: Effects on human peripheral lymphocytes of in vivo administration of 9-β-D arabino furanosyl-2-fluoradenine 5′-monophosphate (NSC 312887), a new purine antimetabolite. Cancer Res 44:4661, 1984
    • (1984) Cancer Res , vol.44 , pp. 4661
    • Boldt, D.H.1    Von Hoff, D.D.2    Kuhn, J.G.3
  • 37
    • 0032503010 scopus 로고    scopus 로고
    • Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver
    • Jager W, Zembsch B, Wolschann P, et al: Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver. Life Sci 62:1861-1873, 1998
    • (1998) Life Sci , vol.62 , pp. 1861-1873
    • Jager, W.1    Zembsch, B.2    Wolschann, P.3
  • 38
    • 0029123452 scopus 로고
    • Plasma pharmacokinetics of genistein in mice
    • Supko J, Malspeis L: Plasma pharmacokinetics of genistein in mice. Int J Oncol 7:847-854, 1995
    • (1995) Int J Oncol , vol.7 , pp. 847-854
    • Supko, J.1    Malspeis, L.2
  • 39
    • 0001029092 scopus 로고    scopus 로고
    • Flavopiridol pharmacokinetics suggest enterohepatic circulation
    • abstr
    • Lush R, Stinson S, Senderowicz A, et al: Flavopiridol pharmacokinetics suggest enterohepatic circulation. Clin Pharmacol Ther 61:145, 1997 (abstr)
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 145
    • Lush, R.1    Stinson, S.2    Senderowicz, A.3
  • 40
    • 0029904810 scopus 로고    scopus 로고
    • Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 lung carcinoma cells
    • Bible KC, Kaufmann SM: Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 lung carcinoma cells. Cancer Res 56:4856-4861, 1996
    • (1996) Cancer Res , vol.56 , pp. 4856-4861
    • Bible, K.C.1    Kaufmann, S.M.2
  • 41
    • 0030812207 scopus 로고    scopus 로고
    • Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
    • Bible KC, Kaufmann SM: Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration. Cancer Res 57:3375-3380, 1997
    • (1997) Cancer Res , vol.57 , pp. 3375-3380
    • Bible, K.C.1    Kaufmann, S.M.2
  • 42
    • 0030824869 scopus 로고    scopus 로고
    • Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells
    • Schwartz GK, Farsi K, Maslak P, et al: Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells. Clin Cancer Res 3:1467-1472, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 1467-1472
    • Schwartz, G.K.1    Farsi, K.2    Maslak, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.