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Volumn 17, Issue 12, 1997, Pages 7306-7316

Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ALPHA AMANITIN; PROTEIN P53; RNA POLYMERASE II;

EID: 0030666852     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.12.7306     Document Type: Article
Times cited : (80)

References (58)
  • 1
    • 0023148157 scopus 로고
    • Localization of an α-amanitin resistance mutation in the gene encoding the largest subunit of mouse RNA polymerase II
    • Bartolomei, M. S., and J. L. Corden. 1987. Localization of an α-amanitin resistance mutation in the gene encoding the largest subunit of mouse RNA polymerase II. Mol. Cell. Biol. 7:586-594.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 586-594
    • Bartolomei, M.S.1    Corden, J.L.2
  • 2
    • 0029774760 scopus 로고    scopus 로고
    • Characterisation of human cyclin G1 and G2: DNA damage inducible genes
    • Bates, S., S. Rowan, and K. H. Vousden. 1996. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. Oncogene 13:1103-1109.
    • (1996) Oncogene , vol.13 , pp. 1103-1109
    • Bates, S.1    Rowan, S.2    Vousden, K.H.3
  • 3
    • 0029670589 scopus 로고    scopus 로고
    • p53 in signaling checkpoint arrest or apoptosis
    • Bates, S., and K. H. Vousden. 1996. p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6:12-18.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 12-18
    • Bates, S.1    Vousden, K.H.2
  • 4
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-alpha-induced cell death
    • Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-alpha-induced cell death. Science 274:782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 5
    • 0029054750 scopus 로고
    • Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3
    • Borner, M. M., C. E. Myers, O. Sartor, Y. Sei, T. Toko, J. B. Trepel, and E. Schneider. 1995. Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. Cancer Res. 55:2122-2128.
    • (1995) Cancer Res. , vol.55 , pp. 2122-2128
    • Borner, M.M.1    Myers, C.E.2    Sartor, O.3    Sei, Y.4    Toko, T.5    Trepel, J.B.6    Schneider, E.7
  • 6
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles, C., A. Helmberg, and M. Karin. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370: 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 7
    • 0029248011 scopus 로고
    • Induction of apoptosis by tumor suppressor genes and oncogenes
    • Canman, C. E., and M. B. Kastan. 1995. Induction of apoptosis by tumor suppressor genes and oncogenes. Semin. Cancer Biol. 6:17-25.
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 17-25
    • Canman, C.E.1    Kastan, M.B.2
  • 9
    • 0026712192 scopus 로고
    • The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle
    • Cotter, T. G., J. M. Glynn, F. Echeverri, and D. R. Green. 1992. The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Res. 12:773-779.
    • (1992) Anticancer Res. , vol.12 , pp. 773-779
    • Cotter, T.G.1    Glynn, J.M.2    Echeverri, F.3    Green, D.R.4
  • 10
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A which is inhibited by E1B
    • Debbas, M., and E. White. 1993. Wild-type p53 mediates apoptosis by E1A which is inhibited by E1B. Genes Dev. 7:546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 11
    • 0024565492 scopus 로고
    • Studies on the inhibition by alpha-amanitin of single-step addition reactions and productive RNA synthesis catalysed by wheat-germ RNA polymerase II
    • De Mercoyrol, L., C. Job, and D. Job. 1989. Studies on the inhibition by alpha-amanitin of single-step addition reactions and productive RNA synthesis catalysed by wheat-germ RNA polymerase II. Biochem. J. 258:165-169.
    • (1989) Biochem. J. , vol.258 , pp. 165-169
    • De Mercoyrol, L.1    Job, C.2    Job, D.3
  • 12
    • 0030601333 scopus 로고    scopus 로고
    • Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors
    • Desnoyers, S., S. H. Kaufman, and G. G. Poirier. 1996. Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors. Exp. Cell Res. 227:146-153.
    • (1996) Exp. Cell Res. , vol.227 , pp. 146-153
    • Desnoyers, S.1    Kaufman, S.H.2    Poirier, G.G.3
  • 13
    • 0028242341 scopus 로고
    • Inhibitors of transcription such as 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxy-terminal domain of RNA polymerase II largest subunit
    • Dubois, M.-F., V. T. Nguyen, S. Bellier, and O. Bensaude. 1994. Inhibitors of transcription such as 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxy-terminal domain of RNA polymerase II largest subunit. J. Biol. Chem. 269:13331-13336.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13331-13336
    • Dubois, M.-F.1    Nguyen, V.T.2    Bellier, S.3    Bensaude, O.4
  • 17
    • 0030067856 scopus 로고    scopus 로고
    • Hypoxic stress proteins: Survival of the fittest
    • Giaccia, A. 1996. Hypoxic stress proteins: survival of the fittest. Semin. Radiat. Oncol. 6:46-58.
    • (1996) Semin. Radiat. Oncol. , vol.6 , pp. 46-58
    • Giaccia, A.1
  • 18
    • 0027386228 scopus 로고
    • Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin
    • Gong, J., X. Li, and Z. Darzynkiewicz. 1993. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J. Cell. Physiol. 157:263-270.
    • (1993) J. Cell. Physiol. , vol.157 , pp. 263-270
    • Gong, J.1    Li, X.2    Darzynkiewicz, Z.3
  • 19
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
    • Graeber, T. G., C. Osmanian, T. Jacks, D. E. Housman, C. J. Koch, S. W. Lowe, and A. J. Giaccia. 1996. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 21
    • 0030005052 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains
    • Haaf, T., and D. C. Ward. 1996. Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains. Exp. Cell Res. 224:163-173.
    • (1996) Exp. Cell Res. , vol.224 , pp. 163-173
    • Haaf, T.1    Ward, D.C.2
  • 23
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Y. Barak, and M. Oren. 1996. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15:1596.
    • (1996) EMBO J. , vol.15 , pp. 1596
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 24
    • 0028837242 scopus 로고
    • Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor
    • Helmberg, A., N. Auphan. C. Caelles, and M. Karin. 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452-460.
    • (1995) EMBO J. , vol.14 , pp. 452-460
    • Helmberg, A.1    Auphan, N.2    Caelles, C.3    Karin, M.4
  • 25
    • 0028786981 scopus 로고
    • Programmed cell death by default in embryonic cells, fibroblasts and cancer cells
    • Ishizaki, Y., L. Cheng, A. W. Mudge, and M. C. Raff. 1995. Programmed cell death by default in embryonic cells, fibroblasts and cancer cells. Mol. Biol. Cell 6:1443-1458.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1443-1458
    • Ishizaki, Y.1    Cheng, L.2    Mudge, A.W.3    Raff, M.C.4
  • 26
    • 0028927179 scopus 로고
    • p53. cell cycle control and apoptosis: Implications for cancer
    • Kastan, M. B., C. E. Canman, and C. J. Leonard. 1995. p53. cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev. 14:3-15.
    • (1995) Cancer Metastasis Rev. , vol.14 , pp. 3-15
    • Kastan, M.B.1    Canman, C.E.2    Leonard, C.J.3
  • 30
    • 0027217846 scopus 로고
    • Investigations of antisense oligonucleotides targeted against bcl-2 RNAs
    • Kitada, S., T. Miyashita, S. Tanaka, and J. C. Reed. 1993. Investigations of antisense oligonucleotides targeted against bcl-2 RNAs. Antisense Res. Dev. 3:157-169.
    • (1993) Antisense Res. Dev. , vol.3 , pp. 157-169
    • Kitada, S.1    Miyashita, T.2    Tanaka, S.3    Reed, J.C.4
  • 31
    • 85036676219 scopus 로고    scopus 로고
    • Unpublished data
    • Koumenis, C., et al. Unpublished data.
    • Koumenis, C.1
  • 32
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 33
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0-G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke, S. P., K. C. Clarkin, A. D. Di Leonardo, A. Tsou, and G. M. Wahl. 1996. A reversible, p53-dependent G0-G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10:934-947.
    • (1996) Genes Dev. , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.D.3    Tsou, A.4    Wahl, G.M.5
  • 34
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T. D., D. C. Hancock, P. S. Danielian, M. G. Parker, and G. I. Evan. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 35
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
    • Liu, Z. G., H. Hsu, D. V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 36
    • 0029785723 scopus 로고    scopus 로고
    • Blockage of RNA polymerase as a possible trigger for U.V. light-induced apoptosis
    • Ljungman, M., and F. Zhang. 1996. Blockage of RNA polymerase as a possible trigger for U.V. light-induced apoptosis. Oncogene 13:823-831.
    • (1996) Oncogene , vol.13 , pp. 823-831
    • Ljungman, M.1    Zhang, F.2
  • 38
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 39
    • 0023851503 scopus 로고
    • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    • Martin, D. P., R. E. Schmidt, P. S. DiStefano, O. H. Lowry, J. G. Carter, and E. M. J. Johnson. 1988. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:829-844.
    • (1988) J. Cell Biol. , vol.106 , pp. 829-844
    • Martin, D.P.1    Schmidt, R.E.2    Distefano, P.S.3    Lowry, O.H.4    Carter, J.G.5    Johnson, E.M.J.6
  • 40
    • 0002259247 scopus 로고
    • Apoptosis of human leukemia: Induction, morphology, and molecular mechanisms
    • L. D. Tomei and F. O. Cope (ed.), Cold Spring Harbor Laboratory Press, Plainview, N.Y.
    • Martin, S. J., and T. G. Cotter. 1994. Apoptosis of human leukemia: induction, morphology, and molecular mechanisms, p. 185-229. In L. D. Tomei and F. O. Cope (ed.), Apoptosis two: the molecular basis of apoptosis in disease. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
    • (1994) Apoptosis Two: The Molecular Basis of Apoptosis in Disease , pp. 185-229
    • Martin, S.J.1    Cotter, T.G.2
  • 41
    • 0029803281 scopus 로고    scopus 로고
    • Wild-type p53 negatively regulates the expression of a microtubule-associated protein
    • Murphy, M., A. Hinman, and A. J. Levine. 1996. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev. 10:2971-2980.
    • (1996) Genes Dev. , vol.10 , pp. 2971-2980
    • Murphy, M.1    Hinman, A.2    Levine, A.J.3
  • 42
    • 0025817881 scopus 로고
    • Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor
    • Raju, U., C. Koumenis, M. Nunez-Regueiro, and A. Eskin. 1991. Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor. Science 253:673-675.
    • (1991) Science , vol.253 , pp. 673-675
    • Raju, U.1    Koumenis, C.2    Nunez-Regueiro, M.3    Eskin, A.4
  • 43
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell-cycle arrest function in a tumor derived p53 mutant
    • Rowan, S., R. L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K. H. Vousden. 1996. Specific loss of apoptotic but not cell-cycle arrest function in a tumor derived p53 mutant. EMBO J. 15:827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 44
    • 0021259620 scopus 로고
    • Drug-induced dispersal of transcribed rRNA genes and transcriptional products: Immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-β-D-ribofuranosylbenzimidazole
    • Scheer, U., B. Hugle, R. Hazan, and K. M. Rose. 1984. Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-β-D-ribofuranosylbenzimidazole. J. Cell Biol. 99: 672-679.
    • (1984) J. Cell Biol. , vol.99 , pp. 672-679
    • Scheer, U.1    Hugle, B.2    Hazan, R.3    Rose, K.M.4
  • 46
    • 0017116555 scopus 로고
    • Action of dichlorobenzimidazole riboside on RNA synthesis in L-929 and HeLa cells
    • Tamm, I., R. Hand, and L. A. Caliguri. 1976. Action of dichlorobenzimidazole riboside on RNA synthesis in L-929 and HeLa cells. J. Cell Biol. 69:229-240.
    • (1976) J. Cell Biol. , vol.69 , pp. 229-240
    • Tamm, I.1    Hand, R.2    Caliguri, L.A.3
  • 48
    • 0027330973 scopus 로고
    • Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2
    • Vaux, D. L., and I. L. Weissman. 1993. Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2. Mol. Cell. Biol. 13:7000-7005.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7000-7005
    • Vaux, D.L.1    Weissman, I.L.2
  • 49
    • 0029858387 scopus 로고    scopus 로고
    • TNF- And cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
    • Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin Jr., A.S.3
  • 50
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1-15.
    • (1996) Genes Dev. , vol.10 , pp. 1-15
    • White, E.1
  • 51
    • 0025885621 scopus 로고
    • Fifty years of amanitin
    • Wieland, T., and H. Faulstich. 1991. Fifty years of amanitin. Experientia 47:1186-1193.
    • (1991) Experientia , vol.47 , pp. 1186-1193
    • Wieland, T.1    Faulstich, H.2
  • 52
    • 0026018901 scopus 로고
    • A central role for chromosome breakage in gene amplification, deletion formation and amplicon integration
    • Windle, B., B. W. Draper, Y. X. Yin, S. O'Gorman, and G. M. Wahl. 1991. A central role for chromosome breakage in gene amplification, deletion formation and amplicon integration. Genes Dev. 5:160-174.
    • (1991) Genes Dev. , vol.5 , pp. 160-174
    • Windle, B.1    Draper, B.W.2    Yin, Y.X.3    O'Gorman, S.4    Wahl, G.M.5
  • 53
    • 0028782774 scopus 로고
    • Death from inside out: An overview
    • Wyllie, A. H. 1994. Death from inside out: an overview. Philos. Trans. R. Soc. Lond. B. 345:237-241.
    • (1994) Philos. Trans. R. Soc. Lond. B. , vol.345 , pp. 237-241
    • Wyllie, A.H.1
  • 54
    • 0028939862 scopus 로고
    • The genetic regulation of apoptosis
    • Wyllie, A. H. 1995. The genetic regulation of apoptosis. Curr. Opin. Genet. Dev. 5:97-104.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 97-104
    • Wyllie, A.H.1
  • 55
    • 0028030791 scopus 로고
    • UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
    • Yamaizumi, M., and T. Sugano. 1994. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9:2775-2784.
    • (1994) Oncogene , vol.9 , pp. 2775-2784
    • Yamaizumi, M.1    Sugano, T.2
  • 56
    • 0028787404 scopus 로고
    • The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosyl-benzimidazole inhibits transcription factor IIH-associated protein kinase
    • Yankoulov, K., K. Yamashita, R. Roy, J.-M. Egly, and D. L. Bentley. 1995. The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosyl-benzimidazole inhibits transcription factor IIH-associated protein kinase. J. Biol. Chem. 41:23922-23925.
    • (1995) J. Biol. Chem. , vol.41 , pp. 23922-23925
    • Yankoulov, K.1    Yamashita, K.2    Roy, R.3    Egly, J.-M.4    Bentley, D.L.5
  • 57
    • 0009577682 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis
    • Yoon, Y. S., J. W. Kim, K. W. Kang, Y. S. Kim, K. H. Choi, and C. O. Joe. 1996. Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis. J. Biol. Chem. 271:9129-9134.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9129-9134
    • Yoon, Y.S.1    Kim, J.W.2    Kang, K.W.3    Kim, Y.S.4    Choi, K.H.5    Joe, C.O.6
  • 58
    • 0019902611 scopus 로고
    • Mechanism of action of dichloro-β-D-ribofuranosylbenzimidazole: Effect on in vitro transcription
    • Zandomeni, R., B. Mittleman, D. Bunick, S. Ackerman, and R. Weinmann. 1982. Mechanism of action of dichloro-β-D-ribofuranosylbenzimidazole: effect on in vitro transcription. Proc. Natl. Acad. Sci. USA 79: 3167-3170.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3167-3170
    • Zandomeni, R.1    Mittleman, B.2    Bunick, D.3    Ackerman, S.4    Weinmann, R.5


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