Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol

Biochemical and Biophysical Research Communications

Volumn 293, Issue 1, 2002, Pages 566-571

  De Azevedo, Walter Filgueira ^a,b   Canduri, Fernanda ^a,b   Freitas da Silveira, Nelson José ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Bioinformatics; CDK; Drug design; Flavopiridol; Structure

Indexed keywords

2,6 DIAMINO 4 CYCLOHEXYLMETHOXY 5 NITROSOPYRIMIDINE; 6 N (3,3 DIMETHYLALLYL)ADENINE; 6 O CYCLOHEXYLMETHYLGUANINE; ADENINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 9; CYCLIN T1; DECHLOROFLAVOPIRIDOL; ENZYME INHIBITOR; FLAVONE DERIVATIVE; FLAVOPIRIDOL; HYMENIALDISINE; INDIRUBIN; OLOMOUCINE; PKFO 49 38; PURVALANOL B; ROSCOVITINE; STAUROSPORINE; U 55; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CYCLIN-DEPENDENT KINASE 9; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FLAVONOIDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PIPERIDINES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0036295220     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00266-8     Document Type: Article

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