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Volumn 18, Issue 2, 2000, Pages 371-375

Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A University of Chicago phase II consortium study

Author keywords

[No Author keywords available]

Indexed keywords

FLAVOPIRIDOL;

EID: 0033955395     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.2000.18.2.371     Document Type: Article
Times cited : (195)

References (21)
  • 1
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 274:1672-1677, 1996
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 2
    • 0026452974 scopus 로고
    • Growth inhibition and reversible cell cycle arrest of carcinoma cells by flavone L86-8275
    • Kaur G, Stetler-Stevenson M, Sebers S, et al: Growth inhibition and reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 84:1736-1740, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1736-1740
    • Kaur, G.1    Stetler-Stevenson, M.2    Sebers, S.3
  • 3
    • 0028176485 scopus 로고
    • Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275
    • Losiewicz MD, Carlson BA, Kaur G, et al: Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Comm 201:589-595, 1994
    • (1994) Biochem Biophys Res Comm , vol.201 , pp. 589-595
    • Losiewicz, M.D.1    Carlson, B.A.2    Kaur, G.3
  • 5
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
    • Carlson BA, Dubay MM, Sausville EA, et al: Flavopiridol induces G1 arrest with inhibition of cyclin dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 56:2973-2978, 1996
    • (1996) Cancer Res , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3
  • 6
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
    • Arguello F, Alexander M, Sterry JA, et al: Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood 91:2482-2490, 1998
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1    Alexander, M.2    Sterry, J.A.3
  • 7
    • 0029904810 scopus 로고    scopus 로고
    • Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells
    • Bible KC, Kaufmann SH: Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res 56:4856-4861, 1996
    • (1996) Cancer Res , vol.56 , pp. 4856-4861
    • Bible, K.C.1    Kaufmann, S.H.2
  • 8
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • Konig A, Schwartz GK, Mohammad RM, et al: The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 90:4307-4312, 1997
    • (1997) Blood , vol.90 , pp. 4307-4312
    • Konig, A.1    Schwartz, G.K.2    Mohammad, R.M.3
  • 9
    • 0031963058 scopus 로고    scopus 로고
    • Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
    • Parker BW, Kaur G, Nieves-Neira W, et al: Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 91:458-465, 1998
    • (1998) Blood , vol.91 , pp. 458-465
    • Parker, B.W.1    Kaur, G.2    Nieves-Neira, W.3
  • 10
    • 0032212885 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
    • Patel V, Senderowicz AM, Pinto D Jr, et al: Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J Clin Invest 102:1674-1681, 1998
    • (1998) J Clin Invest , vol.102 , pp. 1674-1681
    • Patel, V.1    Senderowicz, A.M.2    Pinto D., Jr.3
  • 11
    • 0002128714 scopus 로고    scopus 로고
    • In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer
    • Chien M, Astumian M, Liebowitz D, et al: In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer. Cancer Chem Pharm 44:81-87, 1999
    • (1999) Cancer Chem Pharm , vol.44 , pp. 81-87
    • Chien, M.1    Astumian, M.2    Liebowitz, D.3
  • 12
    • 0040379168 scopus 로고    scopus 로고
    • Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells
    • Brusselbach S, Nettelbeck DM, Sedlacek HH, et al: Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells. Int J Cancer 77:146-152, 1998
    • (1998) Int J Cancer , vol.77 , pp. 146-152
    • Brusselbach, S.1    Nettelbeck, D.M.2    Sedlacek, H.H.3
  • 13
    • 0030213563 scopus 로고    scopus 로고
    • Expression patterns of multidrug-resistance (MDR1), multidrug resistance-associated protein (MRP), glutathione-S-transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) genes in renal cell carcinomas and normal kidney
    • Kim WJ, Kakehi Y, Kinoshita H, et al: Expression patterns of multidrug-resistance (MDR1), multidrug resistance-associated protein (MRP), glutathione-S-transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) genes in renal cell carcinomas and normal kidney. J Urol 156:506-511, 1996
    • (1996) J Urol , vol.156 , pp. 506-511
    • Kim, W.J.1    Kakehi, Y.2    Kinoshita, H.3
  • 14
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy
    • Sedlacek HH, Czech J, Naik R, et al: Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy. Int J Oncol 9:1143-1168, 1996
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.H.1    Czech, J.2    Naik, R.3
  • 15
    • 0031019034 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
    • Drees M, Dengler W, Roth T, et al: Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin Cancer Res 32:273-279, 1997
    • (1997) Clin Cancer Res , vol.32 , pp. 273-279
    • Drees, M.1    Dengler, W.2    Roth, T.3
  • 16
    • 0031670668 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
    • Senderowicz AM, Headlee D, Stinson SF, et al: Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 16:2986-2999, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 2986-2999
    • Senderowicz, A.M.1    Headlee, D.2    Stinson, S.F.3
  • 17
  • 18
    • 0024247135 scopus 로고
    • Prognostic factors for survival in patients with recurrent or metastatic renal cell carcinoma
    • Elson PJ, Witte RS, Trump DL: Prognostic factors for survival in patients with recurrent or metastatic renal cell carcinoma. Cancer Res 48:7310-7313, 1988
    • (1988) Cancer Res , vol.48 , pp. 7310-7313
    • Elson, P.J.1    Witte, R.S.2    Trump, D.L.3
  • 19
    • 0030824869 scopus 로고    scopus 로고
    • Potentiation of apoptosis by flavopiridol in mitomycin-C treated gastric and breast cancer cells
    • Schwartz GK, Farsi K, Maslak P, et al: Potentiation of apoptosis by flavopiridol in mitomycin-C treated gastric and breast cancer cells. Clin Cancer Res 3:1467-1472, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 1467-1472
    • Schwartz, G.K.1    Farsi, K.2    Maslak, P.3
  • 20
    • 0030812207 scopus 로고    scopus 로고
    • Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
    • Bible KC, Kaufmann SH: Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration. Cancer Res 57:3375-3380, 1997
    • (1997) Cancer Res , vol.57 , pp. 3375-3380
    • Bible, K.C.1    Kaufmann, S.H.2
  • 21
    • 0002278038 scopus 로고    scopus 로고
    • Chemotherapy for renal cell carcinoma
    • Raghavan D, Scher H, Leibel S, et al (eds): Philadelphia, PA, Lippincott
    • Motzer R, Vogelzang NJ: Chemotherapy for renal cell carcinoma, in Raghavan D, Scher H, Leibel S, et al (eds): Principles and Practice of Genitourinary Oncology. Philadelphia, PA, Lippincott, 1997, pp 885-896
    • (1997) Principles and Practice of Genitourinary Oncology , pp. 885-896
    • Motzer, R.1    Vogelzang, N.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.