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Volumn 15, Issue 5, 2004, Pages 411-419

Flavopiridol: Pleiotropic biological effects enhance its anti-cancer activity

Author keywords

Anti angiogenic agent; Anti proliferative activity; Combination therapy; Cyclin dependent kinase inhibitor; Flavopiridol

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAMPTOTHECIN DERIVATIVE; CASPASE; CISPLATIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTARABINE; DOCETAXEL; FLAVOPIRIDOL; FLUDARABINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IMATINIB; IRINOTECAN; MATRIGEL; MATRIX METALLOPROTEINASE; MITOXANTRONE; PACLITAXEL; PROTEIN KINASE B; RITUXIMAB; SURVIVIN; THREONINE PROTEINASE; TRANSCRIPTION FACTOR E2F1; TRASTUZUMAB; VASCULOTROPIN;

EID: 2942582482     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000127332.06439.47     Document Type: Review
Times cited : (71)

References (64)
  • 1
    • 0033646291 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: Current status
    • Kelland LR. Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. Exp Opin Invest Drugs 2000; 9:2903-2911.
    • (2000) Exp Opin Invest Drugs , vol.9 , pp. 2903-2911
    • Kelland, L.R.1
  • 2
    • 0035055595 scopus 로고    scopus 로고
    • Mechanisms of action of flavopiridol
    • Sedlacek HH. Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol 2001; 38:139-170.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 139-170
    • Sedlacek, H.H.1
  • 3
    • 0037302850 scopus 로고    scopus 로고
    • The use of cyclin-dependent kinase inhibitors alone or in combination with established cytotoxic drugs in cancer chemotherapy
    • Grant S, Roberts JD. The use of cyclin-dependent kinase inhibitors alone or in combination with established cytotoxic drugs in cancer chemotherapy. Drug Resist Updates 2003; 6:15-26.
    • (2003) Drug Resist Updates , vol.6 , pp. 15-26
    • Grant, S.1    Roberts, J.D.2
  • 4
    • 0242708738 scopus 로고    scopus 로고
    • Small-molecule cyclin-dependent kinase modulators
    • Senderowicz AM. Small-molecule cyclin-dependent kinase modulators. Oncogene 2003; 22:6609-6620.
    • (2003) Oncogene , vol.22 , pp. 6609-6620
    • Senderowicz, A.M.1
  • 5
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6
  • 9
    • 0037870053 scopus 로고    scopus 로고
    • Flavopiridol inversely affects p21WAF1/CIP1 and p53 protects p21-sensitive cells from paclitaxel
    • Blagosklonny MV, Darzynkiewicz Z, Figg WD. Flavopiridol inversely affects p21WAF1/CIP1 and p53 protects p21-sensitive cells from paclitaxel. Cancer Biol Ther 2002; 1:420-426.
    • (2002) Cancer Biol Ther , vol.1 , pp. 420-426
    • Blagosklonny, M.V.1    Darzynkiewicz, Z.2    Figg, W.D.3
  • 10
    • 0032724295 scopus 로고    scopus 로고
    • Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small lung cancer cell lines
    • Shapiro GI, Koestner DA, Matranga CB, Rollins BJ. Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small lung cancer cell lines. Clin Cancer Res 1999; 5:2925-2938.
    • (1999) Clin Cancer Res , vol.5 , pp. 2925-2938
    • Shapiro, G.I.1    Koestner, D.A.2    Matranga, C.B.3    Rollins, B.J.4
  • 11
    • 0041488913 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway
    • Alonso M, Tamasdan C, Miller DC, Newcomb EW. Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2003; 2:139-150.
    • (2003) Mol Cancer Ther , vol.2 , pp. 139-150
    • Alonso, M.1    Tamasdan, C.2    Miller, D.C.3    Newcomb, E.W.4
  • 12
    • 0141499968 scopus 로고    scopus 로고
    • Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor
    • Newcomb EW, Tamasdan C, Entzminger Y, Alonso J, Friedlander D, Crisan D, et al. Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor. Cell Cycle 2003; 2:243-250.
    • (2003) Cell Cycle , vol.2 , pp. 243-250
    • Newcomb, E.W.1    Tamasdan, C.2    Entzminger, Y.3    Alonso, J.4    Friedlander, D.5    Crisan, D.6
  • 13
    • 0242694891 scopus 로고    scopus 로고
    • Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity
    • Jiang J, Matranga CB, Cai D, Lathan Jr VM, Zhang X, Lowell AM, et al. Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity. Cancer Res 2003; 63:7410-7422.
    • (2003) Cancer Res , vol.63 , pp. 7410-7422
    • Jiang, J.1    Matranga, C.B.2    Cai, D.3    Lathan Jr., V.M.4    Zhang, X.5    Lowell, A.M.6
  • 14
    • 0242468166 scopus 로고    scopus 로고
    • Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process
    • Dai Y, Rahmani M, Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process. Oncogene 2003; 22:7108-7122.
    • (2003) Oncogene , vol.22 , pp. 7108-7122
    • Dai, Y.1    Rahmani, M.2    Grant, S.3
  • 15
    • 1042278138 scopus 로고    scopus 로고
    • 1, cyclooxygenase-2 and matrix metalloprotease-9
    • 1, cyclooxygenase-2 and matrix metalloprotease-9. J Biol Chem 2004; 279:4750-4759.
    • (2004) J Biol Chem , vol.279 , pp. 4750-4759
    • Takada, Y.1    Aggarwal, B.B.2
  • 16
    • 0037019830 scopus 로고    scopus 로고
    • Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio
    • Javelaud D, Besancon F. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J Biol Chem 2002; 277:37949-37954.
    • (2002) J Biol Chem , vol.277 , pp. 37949-37954
    • Javelaud, D.1    Besancon, F.2
  • 17
    • 0035233239 scopus 로고    scopus 로고
    • Genome-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
    • Lam LT, Pickeral OK, Peng AC, Rosenwald A, Hurt EM, Giltnane JM, et al. Genome-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol 2001; 2:1-11.
    • (2001) Genome Biol , vol.2 , pp. 1-11
    • Lam, L.T.1    Pickeral, O.K.2    Peng, A.C.3    Rosenwald, A.4    Hurt, E.M.5    Giltnane, J.M.6
  • 18
    • 0036220822 scopus 로고    scopus 로고
    • Complexities in the development of cyclin-dependent kinase inhibitor drugs
    • Sausville EA. Complexities in the development of cyclin-dependent kinase inhibitor drugs. Trends Mol Med 2002; 8:32-37.
    • (2002) Trends Mol Med , vol.8 , pp. 32-37
    • Sausville, E.A.1
  • 19
    • 0029904810 scopus 로고    scopus 로고
    • Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 human lung carcinoma cells
    • Bible KC, Kaufmann SH. Flavopiridol: a cytotoxic flavone that induces cell death in non-cycling A549 human lung carcinoma cells. Cancer Res 1996; 56:4856-4861.
    • (1996) Cancer Res , vol.56 , pp. 4856-4861
    • Bible, K.C.1    Kaufmann, S.H.2
  • 20
    • 0037086282 scopus 로고    scopus 로고
    • Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase
    • Matranga CB, Shapiro GI. Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase. Cancer Res 2002; 62:1707-1717.
    • (2002) Cancer Res , vol.62 , pp. 1707-1717
    • Matranga, C.B.1    Shapiro, G.I.2
  • 21
    • 0141925942 scopus 로고    scopus 로고
    • Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction
    • Litz J, Carlson P, Warshamana-Greene GS, Grant S, Krystal GW. Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction. Clin Cancer Res 2003; 9:4586-4594.
    • (2003) Clin Cancer Res , vol.9 , pp. 4586-4594
    • Litz, J.1    Carlson, P.2    Warshamana-Greene, G.S.3    Grant, S.4    Krystal, G.W.5
  • 23
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • Konig A, Schwartz GK, Mohammad RM, Al-Katib A, Gabrilove JL. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 1997; 30:4307-4312.
    • (1997) Blood , vol.30 , pp. 4307-4312
    • Konig, A.1    Schwartz, G.K.2    Mohammad, R.M.3    Al-Katib, A.4    Gabrilove, J.L.5
  • 24
    • 0034661538 scopus 로고    scopus 로고
    • Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia
    • Kitada S, Zapata JM, Andreeff M, Reed JC. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 2000; 96:393-397.
    • (2000) Blood , vol.96 , pp. 393-397
    • Kitada, S.1    Zapata, J.M.2    Andreeff, M.3    Reed, J.C.4
  • 26
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo I, Zhang B, Fenton RG. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res 2002; 8:3527-3538.
    • (2002) Clin Cancer Res , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 27
    • 20244362748 scopus 로고    scopus 로고
    • Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis
    • Wittmann S, Bali P, Donapaty S, Nimmanapalli R, Quo F, Yamaguchi H, et al. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. Cancer Res 2003; 63:93-99.
    • (2003) Cancer Res , vol.63 , pp. 93-99
    • Wittmann, S.1    Bali, P.2    Donapaty, S.3    Nimmanapalli, R.4    Quo, F.5    Yamaguchi, H.6
  • 28
    • 0033960068 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol
    • Li Y, Bhuiyan M, Alhasan S, Senderowicz AM, Sarkar FH. Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. Clin Cancer Res 2000; 5:223-229.
    • (2000) Clin Cancer Res , vol.5 , pp. 223-229
    • Li, Y.1    Bhuiyan, M.2    Alhasan, S.3    Senderowicz, A.M.4    Sarkar, F.H.5
  • 29
    • 17944366044 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant P53 genes
    • Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, et al. Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant P53 genes. Blood Cells Mol Dis 2001; 27:610-624.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 610-624
    • Rapoport, A.P.1    Simons-Evelyn, M.2    Chen, T.3    Sidell, R.4    Luhowskyj, S.5    Rosell, K.6
  • 30
    • 0036259143 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways
    • Cartee L, Smith R, Dai Y, Rahmani M, Rosato R, Almenara J, et al. Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Mol Pharmacol 2002; 61:1313-1321.
    • (2002) Mol Pharmacol , vol.61 , pp. 1313-1321
    • Cartee, L.1    Smith, R.2    Dai, Y.3    Rahmani, M.4    Rosato, R.5    Almenara, J.6
  • 31
    • 0037446980 scopus 로고    scopus 로고
    • The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
    • Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, et al. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res 2003; 64:1822-1833.
    • (2003) Cancer Res , vol.64 , pp. 1822-1833
    • Yu, C.1    Rahmani, M.2    Dai, Y.3    Conrad, D.4    Krystal, G.5    Dent, P.6
  • 32
    • 0034644659 scopus 로고    scopus 로고
    • Bcl-2 independence of flavopiridol-induced apoptosis
    • Achenbach TV, Muller R, Slater EP. Bcl-2 independence of flavopiridol-induced apoptosis. J Biol Chem 2000; 275:32089-32097.
    • (2000) J Biol Chem , vol.275 , pp. 32089-32097
    • Achenbach, T.V.1    Muller, R.2    Slater, E.P.3
  • 33
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 34
    • 0036020941 scopus 로고    scopus 로고
    • NF-κB as a therapeutic target in cancer
    • Orlowski RZ, Baldwin Jr AS. NF-κB as a therapeutic target in cancer. Trends Mol Med 2002; 8:385-389.
    • (2002) Trends Mol Med , vol.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin Jr., A.S.2
  • 35
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. Nature 1998; 394:485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 36
    • 0040379168 scopus 로고    scopus 로고
    • Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells
    • Brusselbach S, Nettlebeck DM, Sedlacek HH, Muller R. Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells. Int J Cancer 1998; 77:146-152.
    • (1998) Int J Cancer , vol.77 , pp. 146-152
    • Brusselbach, S.1    Nettlebeck, D.M.2    Sedlacek, H.H.3    Muller, R.4
  • 37
    • 0346250160 scopus 로고    scopus 로고
    • Survivin, versatile modulation of cell division and apoptosis in cancer
    • Altieri DC. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene 2003; 22:8581-8589.
    • (2003) Oncogene , vol.22 , pp. 8581-8589
    • Altieri, D.C.1
  • 38
    • 0033870417 scopus 로고    scopus 로고
    • Control of apoptosis during angiogenesis by survivin expression in endothelial cells
    • O'Connor DS, Schechner JS, Adida C, Mesri M, Rothermel AL, Li F, et al. Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol 2000; 156:393-398.
    • (2000) Am J Pathol , vol.156 , pp. 393-398
    • O'Connor, D.S.1    Schechner, J.S.2    Adida, C.3    Mesri, M.4    Rothermel, A.L.5    Li, F.6
  • 43
    • 0033231301 scopus 로고    scopus 로고
    • Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
    • Melillo G, Sausville EA, Cloud K, Lahusen T, Varesio L, Senderowicz AM. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res 1999; 59:5433-5437.
    • (1999) Cancer Res , vol.59 , pp. 5433-5437
    • Melillo, G.1    Sausville, E.A.2    Cloud, K.3    Lahusen, T.4    Varesio, L.5    Senderowicz, A.M.6
  • 44
    • 0036101635 scopus 로고    scopus 로고
    • Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma
    • Rapella A, Negrioli A, Melillo G, Pastorino S, Varesio L, Bosco MC. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Int J Cancer 2002; 99:658-664.
    • (2002) Int J Cancer , vol.99 , pp. 658-664
    • Rapella, A.1    Negrioli, A.2    Melillo, G.3    Pastorino, S.4    Varesio, L.5    Bosco, M.C.6
  • 45
    • 0036682284 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
    • Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002; 62:4316-4324.
    • (2002) Cancer Res , vol.62 , pp. 4316-4324
    • Rapisarda, A.1    Uranchimeg, B.2    Scudiero, D.A.3    Selby, M.4    Sausville, E.A.5    Shoemaker, R.H.6
  • 47
    • 0035679234 scopus 로고    scopus 로고
    • Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts
    • Motwani M, Jung C, Sirotnak FM, She Y, Shah MA, Gonen M, et al. Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. Clin Cancer Res 2001; 7:4209-4219.
    • (2001) Clin Cancer Res , vol.7 , pp. 4209-4219
    • Motwani, M.1    Jung, C.2    Sirotnak, F.M.3    She, Y.4    Shah, M.A.5    Gonen, M.6
  • 48
    • 2442703950 scopus 로고    scopus 로고
    • Flavopiridol inhibits the growth of GL261 gliomas in vivo: Implications for malignant glioma therapy
    • Newcomb EW, Tamasdan C, Entzminger Y, Arena E, Schnee T, Kim M et al. Flavopiridol inhibits the growth of GL261 gliomas in vivo: Implications for malignant glioma therapy. Cell Cycle 2004; 3:230-234.
    • (2004) Cell Cycle , vol.3 , pp. 230-234
    • Newcomb, E.W.1    Tamasdan, C.2    Entzminger, Y.3    Arena, E.4    Schnee, T.5    Kim, M.6
  • 49
    • 0031019034 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
    • Drees M, Dengler WA, Roth T, Labonte H, Mayo J, Malspies L, et al. Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin Cancer Res 1997; 3: 273-279.
    • (1997) Clin Cancer Res , vol.3 , pp. 273-279
    • Drees, M.1    Dengler, W.A.2    Roth, T.3    Labonte, H.4    Mayo, J.5    Malspies, L.6
  • 50
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridool induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
    • Arguello F, Alexander M, Sterry JA, Tudor G, Smith EM, Kalavar NT, et al. Flavopiridool induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood 1998; 91: 2482-2490.
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1    Alexander, M.2    Sterry, J.A.3    Tudor, G.4    Smith, E.M.5    Kalavar, N.T.6
  • 51
    • 0032212885 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
    • Patel V, Senderowicz AM, Pinto D Jr, Igishi T, Raffeld M, Quintanilla-Martinez L, et al. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J Clin Invest 1998; 102:1674-1681.
    • (1998) J Clin Invest , vol.102 , pp. 1674-1681
    • Patel, V.1    Senderowicz, A.M.2    Pinto Jr., D.3    Igishi, T.4    Raffeld, M.5    Quintanilla-Martinez, L.6
  • 52
    • 0031670668 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
    • Senderowicz AM, Headlee D, Stinson SF, Lush RM, Kalil N, Villalba L, et al. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 1998; 16:2986-2999.
    • (1998) J Clin Oncol , vol.16 , pp. 2986-2999
    • Senderowicz, A.M.1    Headlee, D.2    Stinson, S.F.3    Lush, R.M.4    Kalil, N.5    Villalba, L.6
  • 54
    • 0036240601 scopus 로고    scopus 로고
    • Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma
    • Lin TS, Howard OM, Neuberg DS, Kim HH, Shipp MA. Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leuk Lymphoma 2002; 43:793-797.
    • (2002) Leuk Lymphoma , vol.43 , pp. 793-797
    • Lin, T.S.1    Howard, O.M.2    Neuberg, D.S.3    Kim, H.H.4    Shipp, M.A.5
  • 55
    • 0033955395 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A University of Chicago Phase II Consortium study
    • Stadler WM, Vogelzang NJ, Amato R, Sosman J, Taber D, Liebowitz D, et al. Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: a University of Chicago Phase II Consortium study. J Clin Oncol 2000; 18:371-375.
    • (2000) J Clin Oncol , vol.18 , pp. 371-375
    • Stadler, W.M.1    Vogelzang, N.J.2    Amato, R.3    Sosman, J.4    Taber, D.5    Liebowitz, D.6
  • 56
    • 0034900178 scopus 로고    scopus 로고
    • A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer
    • Shapiro GI, Supko JG, Patterson A, Lynch C, Lucca J, Zacarola PF, et al. A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer. Clin Cancer Res 2001; 7:1590-1599.
    • (2001) Clin Cancer Res , vol.7 , pp. 1590-1599
    • Shapiro, G.I.1    Supko, J.G.2    Patterson, A.3    Lynch, C.4    Lucca, J.5    Zacarola, P.F.6
  • 57
    • 0035300684 scopus 로고    scopus 로고
    • Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma
    • Schwartz GK, Ilson D, Saltz L, O'Reilly E, Tong W, Maslak P, et al. Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma. J Clin Oncol 2001; 19: 1985-1992.
    • (2001) J Clin Oncol , vol.19 , pp. 1985-1992
    • Schwartz, G.K.1    Ilson, D.2    Saltz, L.3    O'Reilly, E.4    Tong, W.5    Maslak, P.6
  • 58
    • 0043011497 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in patients with advanced colorectal cancer
    • Aklilu M, Kindler HL, Donehower RC, Mani S, Vokes EE. Phase II study of flavopiridol in patients with advanced colorectal cancer. Ann Oncol 2003; 14:1270-1273.
    • (2003) Ann Oncol , vol.14 , pp. 1270-1273
    • Aklilu, M.1    Kindler, H.L.2    Donehower, R.C.3    Mani, S.4    Vokes, E.E.5
  • 59
    • 0036789539 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms
    • Tan AR, Headlee D, Messmann R, Sausville EA, Arbuck SG, Murgo AJ, et al. Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. J Clin Oncol 2002; 20:4074-4082.
    • (2002) J Clin Oncol , vol.20 , pp. 4074-4082
    • Tan, A.R.1    Headlee, D.2    Messmann, R.3    Sausville, E.A.4    Arbuck, S.G.5    Murgo, A.J.6
  • 60
    • 0037332266 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms
    • Zhai S, Sausville EA, Senderowicz AM, Ando Y, Headlee D, Messmann RA, et al. Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms. Anticancer Drugs 2003; 14:125-135.
    • (2003) Anticancer Drugs , vol.14 , pp. 125-135
    • Zhai, S.1    Sausville, E.A.2    Senderowicz, A.M.3    Ando, Y.4    Headlee, D.5    Messmann, R.A.6
  • 61
    • 0038473927 scopus 로고    scopus 로고
    • Flavopiridol in untreated or relapsed mantle-cell lymphoma: Results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group
    • Kouroukis CT, Belch A, Crump M, Eisenhauer E, Gascoyne RD, Meyer R, et al. Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003; 21:1740-1745.
    • (2003) J Clin Oncol , vol.21 , pp. 1740-1745
    • Kouroukis, C.T.1    Belch, A.2    Crump, M.3    Eisenhauer, E.4    Gascoyne, R.D.5    Meyer, R.6
  • 62
    • 0037089691 scopus 로고    scopus 로고
    • Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors
    • Schwartz GK, O'Reilly E, Ilson D, Saltz L, Sharma S, Tong W, et al. Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors. J Clin Oncol 2002; 20:2157-2170
    • (2002) J Clin Oncol , vol.20 , pp. 2157-2170
    • Schwartz, G.K.1    O'Reilly, E.2    Ilson, D.3    Saltz, L.4    Sharma, S.5    Tong, W.6
  • 63
    • 0038745560 scopus 로고    scopus 로고
    • Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells
    • Raju U, Nakata E, Mason KA, Ang KK, Milas L. Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res 2003; 63:3263-3267.
    • (2003) Cancer Res , vol.63 , pp. 3263-3267
    • Raju, U.1    Nakata, E.2    Mason, K.A.3    Ang, K.K.4    Milas, L.5
  • 64
    • 0346734278 scopus 로고    scopus 로고
    • The cyclin-dependent inhibitor flavopiridol potentiates gamma-irradiation induced apoptosis in colon and gastric cancer cells
    • Jung C, Motwani M, Kortmansky J, Sirotnak FM, She Y, Gonen M, et al. The cyclin-dependent inhibitor flavopiridol potentiates gamma-irradiation induced apoptosis in colon and gastric cancer cells. Clin Cancer Res 2003; 9:6052-6061.
    • (2003) Clin Cancer Res , vol.9 , pp. 6052-6061
    • Jung, C.1    Motwani, M.2    Kortmansky, J.3    Sirotnak, F.M.4    She, Y.5    Gonen, M.6


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