-
1
-
-
0026452974
-
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
-
Kaur G, Stetler-Stevenson M, Sehers S, Worland R, Sedlacek H, Myers C, Czech J, Naik R, Sausville E: Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 84:1736, 1992
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1736
-
-
Kaur, G.1
Stetler-Stevenson, M.2
Sehers, S.3
Worland, R.4
Sedlacek, H.5
Myers, C.6
Czech, J.7
Naik, R.8
Sausville, E.9
-
2
-
-
0028917771
-
Antitumoral activity of flavone L86-8275
-
Czech J, Hoffmann D, Naik R, Sedlacek H-H: Antitumoral activity of flavone L86-8275. Int J Oncol 6:31, 1995
-
(1995)
Int J Oncol
, vol.6
, pp. 31
-
-
Czech, J.1
Hoffmann, D.2
Naik, R.3
Sedlacek, H.-H.4
-
3
-
-
0028176485
-
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275
-
Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ: Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Commun 201:589, 1994
-
(1994)
Biochem Biophys Res Commun
, vol.201
, pp. 589
-
-
Losiewicz, M.D.1
Carlson, B.A.2
Kaur, G.3
Sausville, E.A.4
Worland, P.J.5
-
4
-
-
0029665778
-
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase CDK2 and CDK4 in human breast carcinoma cells
-
Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ: Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase CDK2 and CDK4 in human breast carcinoma cells. Cancer Res 56:2973, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 2973
-
-
Carlson, B.A.1
Dubay, M.M.2
Sausville, E.A.3
Brizuela, L.4
Worland, P.J.5
-
6
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
De Azevedo WF Jr. Mueller-Dieckmann HJ, Schulze-Gahmen U, Worland PJ, Sausville E, Kim SH: Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci USA 93:2735, 1996
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2735
-
-
De Azevedo Jr., W.F.1
Mueller-Dieckmann, H.J.2
Schulze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.H.6
-
8
-
-
0027214305
-
Apoptosis: A product of programmed and unprogrammed cell death
-
Eastman A: Apoptosis: A product of programmed and unprogrammed cell death. Toxicol Appl Pharmacol 121:160, 1993
-
(1993)
Toxicol Appl Pharmacol
, vol.121
, pp. 160
-
-
Eastman, A.1
-
9
-
-
0027936034
-
Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemia HL60 cells
-
Solary E, Bertrand R, Pommier Y: Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemia HL60 cells. Leuk Lymphoma 15:21, 1994
-
(1994)
Leuk Lymphoma
, vol.15
, pp. 21
-
-
Solary, E.1
Bertrand, R.2
Pommier, Y.3
-
10
-
-
0026481364
-
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: Association with enhanced fragmentation of mature DNA
-
Grant S, Jarvis WD, Swerdlow PS, Turner AJ, Traylor RS, Wallace HJ, Lin PS, Pettit GR, Gewirtz DA: Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: Association with enhanced fragmentation of mature DNA. Cancer Res 52:6270, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 6270
-
-
Grant, S.1
Jarvis, W.D.2
Swerdlow, P.S.3
Turner, A.J.4
Traylor, R.S.5
Wallace, H.J.6
Lin, P.S.7
Pettit, G.R.8
Gewirtz, D.A.9
-
11
-
-
0029052647
-
Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis
-
Dou QP, An B, Will PL: Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Proc Natl Acad Sci USA 92:9019, 1995
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9019
-
-
Dou, Q.P.1
An, B.2
Will, P.L.3
-
12
-
-
0010641659
-
Phase I trial of a novel cyclin-dependent kinase inhibitor flavopiridol in patients with refractory neoplasms. 9th National Cancer Institute-European Organization for Research on Treatment of Cancer Symposium Proceedings
-
Senderowicz AM, Headlee D, Stinson S, Lush RM. Tompkins A, Brawley O, Bergan R, Figg WD, Smith A, Sausville EA: Phase I trial of a novel cyclin-dependent kinase inhibitor flavopiridol in patients with refractory neoplasms. 9th National Cancer Institute-European Organization for Research on Treatment of Cancer Symposium Proceedings. Ann Oncol 7:77, 1996 (suppl 1)
-
(1996)
Ann Oncol
, vol.7
, Issue.1 SUPPL.
, pp. 77
-
-
Senderowicz, A.M.1
Headlee, D.2
Stinson, S.3
Lush, R.M.4
Tompkins, A.5
Brawley, O.6
Bergan, R.7
Figg, W.D.8
Smith, A.9
Sausville, E.A.10
-
13
-
-
0028966114
-
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton
-
Senderowicz AM, Kaur G, Sainz E, Laing C, Inman WD, Rodriguez J, Crews P, Malspeis L, Grever MR, Sausville EA, Duncan KL: Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton. J Natl Cancer Inst 87:46, 1995
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 46
-
-
Senderowicz, A.M.1
Kaur, G.2
Sainz, E.3
Laing, C.4
Inman, W.D.5
Rodriguez, J.6
Crews, P.7
Malspeis, L.8
Grever, M.R.9
Sausville, E.A.10
Duncan, K.L.11
-
14
-
-
0028990479
-
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2
-
Wang Q, Worland PJ, Clark JL, Carlson BA, Sausville EA: Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth Differ 6:927, 1995
-
(1995)
Cell Growth Differ
, vol.6
, pp. 927
-
-
Wang, Q.1
Worland, P.J.2
Clark, J.L.3
Carlson, B.A.4
Sausville, E.A.5
-
15
-
-
0027168859
-
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
-
Bertrand R, Solary E, Jenkins J, Pommier Y: Apoptosis and its modulation in human promyelocytic HL-60 cells treated With DNA topoisomerase I and II inhibitors. Exp Cell Res 207:388, 1993
-
(1993)
Exp Cell Res
, vol.207
, pp. 388
-
-
Bertrand, R.1
Solary, E.2
Jenkins, J.3
Pommier, Y.4
-
16
-
-
0028237868
-
Effects of DNA methylarion on topoisomerase I and II cleavage activities
-
Leteurtre F, Kohlhagen G, Fesen MR, Tanizawa A, Konn KW, Pommier Y: Effects of DNA methylarion on topoisomerase I and II cleavage activities. J Biol Chem 269:7893, 1994
-
(1994)
J Biol Chem
, vol.269
, pp. 7893
-
-
Leteurtre, F.1
Kohlhagen, G.2
Fesen, M.R.3
Tanizawa, A.4
Konn, K.W.5
Pommier, Y.6
-
17
-
-
0028111312
-
Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives
-
Markovits J, Larsen AK, Segal-Bendirdjian E, Fosse P, Saucier JM, Gazit A, Levitzki A, Umezawa K, Jacquemin-Sablon A: Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives. Biochem Pharmacol 48:549, 1994
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 549
-
-
Markovits, J.1
Larsen, A.K.2
Segal-Bendirdjian, E.3
Fosse, P.4
Saucier, J.M.5
Gazit, A.6
Levitzki, A.7
Umezawa, K.8
Jacquemin-Sablon, A.9
-
18
-
-
0026471968
-
Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT4 and HL-60 cells
-
Traganos F, Ardelt B, Halko N, Bruno S, Darzynkiewicz Z: Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT4 and HL-60 cells. Cancer Res 52:6200, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 6200
-
-
Traganos, F.1
Ardelt, B.2
Halko, N.3
Bruno, S.4
Darzynkiewicz, Z.5
-
19
-
-
0028782781
-
Programmed cell death and the control of cell survival
-
Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD: Programmed cell death and the control of cell survival. Philos Trans R Soc Lond B Biol Sci 345:265, 1994
-
(1994)
Philos Trans R Soc Lond B Biol Sci
, vol.345
, pp. 265
-
-
Raff, M.C.1
Barres, B.A.2
Burne, J.F.3
Coles, H.S.4
Ishizaki, Y.5
Jacobson, M.D.6
-
20
-
-
0027944206
-
P53 status and the efficacy of cancer therapy in vivo
-
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T: p53 status and the efficacy of cancer therapy in vivo. Science 266:807, 1994
-
(1994)
Science
, vol.266
, pp. 807
-
-
Lowe, S.W.1
Bodis, S.2
McClatchey, A.3
Remington, L.4
Ruley, H.E.5
Fisher, D.E.6
Housman, D.E.7
Jacks, T.8
-
21
-
-
0027255417
-
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
-
Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG: Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 3976
-
-
Kaufmann, S.H.1
Desnoyers, S.2
Ottaviano, Y.3
Davidson, N.E.4
Poirier, G.G.5
-
22
-
-
0028013219
-
Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs
-
Del Bino G, Li X, Traganos F, Darzynkiewicz Z: Altered susceptibility of differentiating HL-60 cells to apoptosis induced by antitumor drugs. Leukemia 8:281, 1996
-
(1996)
Leukemia
, vol.8
, pp. 281
-
-
Del Bino, G.1
Li, X.2
Traganos, F.3
Darzynkiewicz, Z.4
-
23
-
-
0019225636
-
Cell death: The significance of apoptosis
-
Wyllie AH: Cell death: The significance of apoptosis. Int Rev Cytol 68:251, 1980
-
(1980)
Int Rev Cytol
, vol.68
, pp. 251
-
-
Wyllie, A.H.1
-
24
-
-
9044225527
-
BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
-
Reed JC, Miyashita T, Takayama S, Wang HG, Sato T, Krajewski S, Aime-Sempe C, Bodrug S, Kitada S, Hanada M: BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60:23, 1996
-
(1996)
J Cell Biochem
, vol.60
, pp. 23
-
-
Reed, J.C.1
Miyashita, T.2
Takayama, S.3
Wang, H.G.4
Sato, T.5
Krajewski, S.6
Aime-Sempe, C.7
Bodrug, S.8
Kitada, S.9
Hanada, M.10
-
25
-
-
0029961061
-
Effect of protease inhibitors on early events of apoptosis
-
Hara S, Halicka HD, Bruno S, Gong J, Traganos F, Darzynkiewicz Z: Effect of protease inhibitors on early events of apoptosis. Exp Cell Res 223:372, 1996
-
(1996)
Exp Cell Res
, vol.223
, pp. 372
-
-
Hara, S.1
Halicka, H.D.2
Bruno, S.3
Gong, J.T.4
Raganos, F.5
Darzynkiewicz, Z.6
-
26
-
-
0027164993
-
Identification of deoxyribonuclease II as an endonuclease involved in apoptosis
-
Barry MA, Eastman A: Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys 300: 440, 1993
-
(1993)
Arch Biochem Biophys
, vol.300
, pp. 440
-
-
Barry, M.A.1
Eastman, A.2
-
27
-
-
0026702883
-
Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH
-
Barry MA, Eastman A: Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH. Biochem Biophys Res Commun 186:782, 1992
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 782
-
-
Barry, M.A.1
Eastman, A.2
-
28
-
-
0027494237
-
P53 oncogene mutations in three human prostate cancer cell lines
-
Carroll AG, Voeller HJ, Sugars L, Gelmann EP: p53 oncogene mutations in three human prostate cancer cell lines. Prostate 23:123, 1993
-
(1993)
Prostate
, vol.23
, pp. 123
-
-
Carroll, A.G.1
Voeller, H.J.2
Sugars, L.3
Gelmann, E.P.4
-
29
-
-
0028881753
-
Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-p53/K562 from apoptosis
-
Magnelli L, Cinelli M, Chiarugi V: Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-p53/K562 from apoptosis. Biochem Biophys Res Commun 215: 641, 1995
-
(1995)
Biochem Biophys Res Commun
, vol.215
, pp. 641
-
-
Magnelli, L.1
Cinelli, M.2
Chiarugi, V.3
-
30
-
-
0028985518
-
P53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation
-
Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB, Mercer WE: p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55:668, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 668
-
-
Zhang, W.1
Grasso, L.2
McClain, C.D.3
Gambel, A.M.4
Cha, Y.5
Travali, S.6
Deisseroth, A.B.7
Mercer, W.E.8
-
31
-
-
11944252783
-
A human temperature-sensitive p53 mutant p53 Val-138: Modulation of the cell cycle, viability and expression of p53 responsive genes
-
Yamato K, Yamamoto M, Hiramo Y, Tsuchida N: A human temperature-sensitive p53 mutant p53 Val-138: modulation of the cell cycle, viability and expression of p53 responsive genes. Oncogene 11:1, 1995
-
(1995)
Oncogene
, vol.11
, pp. 1
-
-
Yamato, K.1
Yamamoto, M.2
Hiramo, Y.3
Tsuchida, N.4
-
32
-
-
0029929039
-
Sublytic complement attack induces cell cycle in oligodendrocytes
-
Rus HG, Niculescu F, Shin ML: Sublytic complement attack induces cell cycle in oligodendrocytes. J Immunol 156:4892, 1996
-
(1996)
J Immunol
, vol.156
, pp. 4892
-
-
Rus, H.G.1
Niculescu, F.2
Shin, M.L.3
-
33
-
-
0029906431
-
BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine
-
Reynolds JE, Li J, Craig RW, Eastman A: BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp Cell Res 225:430, 1996
-
(1996)
Exp Cell Res
, vol.225
, pp. 430
-
-
Reynolds, J.E.1
Li, J.2
Craig, R.W.3
Eastman, A.4
-
34
-
-
0029944142
-
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death
-
Jacobsen MD, Weil M, Raff MC: Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. J Cell Biol 133:1041, 1996
-
(1996)
J Cell Biol
, vol.133
, pp. 1041
-
-
Jacobsen, M.D.1
Weil, M.2
Raff, M.C.3
-
35
-
-
0028873880
-
Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage
-
Shimizu T, O'Connor P, Kohn KW, Pommier Y: Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Res 55:228, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 228
-
-
Shimizu, T.1
O'Connor, P.2
Kohn, K.W.3
Pommier, Y.4
-
36
-
-
0029880622
-
Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases
-
Meikrantz W, Schlegel R: Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem 271:10205, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 10205
-
-
Meikrantz, W.1
Schlegel, R.2
-
37
-
-
0029913242
-
Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
-
Park DS, Farinelli SE, Greene LA: Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 271:8161, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 8161
-
-
Park, D.S.1
Farinelli, S.E.2
Greene, L.A.3
-
38
-
-
0030271304
-
Chemical inhibitors of cyclin-dependent kinases
-
Meijer L: Chemical inhibitors of cyclin-dependent kinases. Trends Cell Biol 6:393, 1996
-
(1996)
Trends Cell Biol
, vol.6
, pp. 393
-
-
Meijer, L.1
-
39
-
-
0029807115
-
Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy
-
Sedlacek HH, Czech J, Naik R, Kaur G, Worland P, Losiewicz M, Parker B, Carlson B, Smith A, Senderowicz A, Sausville E: Flavopiridol (L86-8275, NSC-649890), a new kinase inhibitor for tumor therapy. Int J Oncol 9:1143, 1996
-
(1996)
Int J Oncol
, vol.9
, pp. 1143
-
-
Sedlacek, H.H.1
Czech, J.2
Naik, R.3
Kaur, G.4
Worland, P.5
Losiewicz, M.6
Parker, B.7
Carlson, B.8
Smith, A.9
Senderowicz, A.10
Sausville, E.11
-
40
-
-
0029036412
-
Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
-
Petit PX, Lecoeur H, Zorn E, Dauguet C, Mignotte B, Gougeon ML: Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J Cell Biol 130:157, 1995
-
(1995)
J Cell Biol
, vol.130
, pp. 157
-
-
Petit, P.X.1
Lecoeur, H.2
Zorn, E.3
Dauguet, C.4
Mignotte, B.5
Gougeon, M.L.6
-
41
-
-
0030937953
-
6-Mercaptopurine decreases the bcl-2/bax ratio and induces apoptosis in activated splenic B lymphocytes
-
Horteland S, Bosca L: 6-Mercaptopurine decreases the bcl-2/bax ratio and induces apoptosis in activated splenic B lymphocytes. Mol Pharmacol 51:414, 1997
-
(1997)
Mol Pharmacol
, vol.51
, pp. 414
-
-
Horteland, S.1
Bosca, L.2
-
42
-
-
0001627298
-
The protein kinase C (PKC) inhibitors UCN-01 and flavopiridol significantly enhance the cytotoxic effect of chemotherapy by promoting apoptosis in gastric and breast cells
-
Schwartz GK, Farsi K, Danso D, Dhupar SK, Kelsen D, Spriggs D: The protein kinase C (PKC) inhibitors UCN-01 and flavopiridol significantly enhance the cytotoxic effect of chemotherapy by promoting apoptosis in gastric and breast cells. Proc Am Soc Clin Oncol 15:501, 1996
-
(1996)
Proc Am Soc Clin Oncol
, vol.15
, pp. 501
-
-
Schwartz, G.K.1
Farsi, K.2
Danso, D.3
Dhupar, S.K.4
Kelsen, D.5
Spriggs, D.6
-
43
-
-
0029904810
-
Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells
-
Bible K, Kaufmann S: Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res 56:4856, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 4856
-
-
Bible, K.1
Kaufmann, S.2
|