Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.

Cell cycle (Georgetown, Tex.)

Volumn 2, Issue 1, 2003, Pages 52-57

  Pepper, Chris ^a   Thomas, Alun ^a   Hoy, Terry ^a   Tighe, Jane ^a   Culligan, Dominic ^a   Fegan, Chris ^a   Bentley, Paul ^a  

^a LLANDOUGH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; FLAVONOID; FLAVOPIRIDOL; ONCOPROTEIN; PIPERIDINE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADOLESCENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL CYCLE; CELL TRANSFORMATION; DRUG EFFECT; DRUG RESISTANCE; FAMILIAL CANCER; FEMALE; GENETICS; HUMAN; LEUKEMIA; METABOLISM; MIDDLE AGED; MUTATION; T LYMPHOCYTE;

ADOLESCENT; ANTINEOPLASTIC AGENTS; APOPTOSIS; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLAVONOIDS; HUMANS; LEUKEMIA; LI-FRAUMENI SYNDROME; MIDDLE AGED; MUTATION; PIPERIDINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

MLCS; MLOWN;

EID: 0042697735     PISSN: 15384101     EISSN: None     Source Type: Journal    
DOI: 10.4161/cc.2.1.249     Document Type: Article

References (0)