Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 7, 1996, Pages 2735-2740

  De Azevedo Jr , Walter Filgueira ^a   Mueller Dieckmann, Hans Joachim ^a   Schulze Gahmen, Ursula ^a   Worland, Peter J ^b   Sausville, Edward ^b   Kim, Sung Hou ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

cancer; cyclin dependent kinase; drug design; flavopiridol; protein kinase inhibitors

Indexed keywords

5,7 DIHYDROXY 8 (3 HYDROXY 1 METHYL 4 PIPERIDINYL)FLAVONE; CYCLIN DEPENDENT KINASE; FLAVONE DERIVATIVE; L 868276; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CDC2-CDC28 KINASES; CELL LINE; CHROMONES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; PIPERIDINES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0029993339     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.7.2735     Document Type: Article

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