Design, Synthesis, and Evaluation of Aza-Peptide Epoxides as Selective and Potent Inhibitors of Caspases-1, -3, -6, and -8

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1553-1574

  James, Karen Ellis ^a   Asgian, Juliana L ^a   Li, Zhao Zhao ^a   Ekici, Özlem Doǧan ^a   Rubin, John R ^c   Mikolajczyk, Jowita ^b   Salvesen, Guy S ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE INHIBITOR; CATHEPSIN D; CHYMOTRYPSIN A; EPOXIDE; GRANZYME B; INTERLEUKIN 1BETA CONVERTING ENZYME; NATURAL PRODUCT; PLASMEPSIN II; PROTEINASE INHIBITOR;

ACYLATION; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CYTOKINE RELEASE; DERIVATIZATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PEPTIDE ANALYSIS; RESIDUE ANALYSIS;

AZA COMPOUNDS; CASPASE 1; CASPASE 3; CASPASE 6; CASPASE 8; CASPASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG STABILITY; EPOXY COMPOUNDS; HUMANS; HYDROLYSIS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1542328053     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0305016     Document Type: Article

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