Aza-peptide epoxides: A new class of inhibitors selective for clan CD cysteine proteases

Journal of Medicinal Chemistry

Volumn 45, Issue 23, 2002, Pages 4958-4960

  Asgian, Juliana L ^a   James, Karen Ellis ^a   Li, Zhao Zhao ^a   Carter, Wendy ^b   Barrett, Alan J ^b   Mikolajczyk, Jowita ^c   Salvesen, Guy S ^c   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZAPEPTIDE EPOXIDE; CYSTEINE PROTEINASE INHIBITOR; EPOXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; DERIVATIZATION; ENZYME INHIBITION; ENZYME SUBSTRATE; NERVE DEGENERATION; TISSUE INJURY;

AZA COMPOUNDS; CASPASES; CATHEPSIN B; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; EPOXY COMPOUNDS; KINETICS; OLIGOPEPTIDES; PAPAIN; PLANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037038317     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025581c     Document Type: Article

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18. 3, 1.25 mM EDTA, 0.01% Brij 35, pH 6.0) with Z-RR-AMC as the substrate. For more detailed information, see Supporting Information.