Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: When reaction mechanism is more important than specificity

Cell Death and Differentiation

Volumn 10, Issue 8, 2003, Pages 881-888

  Rozman Pungercar J ^a   Kopitar Jerala, N ^a   Bogyo, M ^b,c   Turk, D ^a   Vasiljeva, O ^a   Stefe, I ^a   Vandenabeele, P ^d   Bromme D ^e   Puizdar, V ^a   Fonovic M ^a   Trstenjak Prebanda, M ^a   Dolenc, I ^a   Turk, V ^a   Turk, Boris ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CELERA   (United States)

^d GHENT UNIVERSITY   (Belgium)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase; Cathepsin; Cysteine protease; Inhibition; Legumain; Specificity

Indexed keywords

ALDEHYDE DERIVATIVE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CATHEPSIN B; CATHEPSIN F; CATHEPSIN H; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDYL PEPTIDASE I; KETONE DERIVATIVE; LEGUMAIN; PAPAIN; PROTEINASE; TISSUE EXTRACT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; REACTION ANALYSIS;

ALDEHYDES; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; CASPASES; CATHEPSINS; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; JURKAT CELLS; KINETICS; LEUCINE; LIVER; OLIGOPEPTIDES; PAPAIN; RATS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 12444315984     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401247     Document Type: Article

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