Caspase-8 specificity probed at subsite S4: Crystal structure of the caspase-8-Z-DEVD-cho complex

Journal of Molecular Biology

Volumn 302, Issue 1, 2000, Pages 9-16

  Blanchard, Helen ^a   Donepudi, Mrudula ^a   Tschopp, Markus ^a   Kodandapani, Lalitha ^b   Wu, Joe C ^b   Grütter, Markus G ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b PFIZER INC   (United States)

Author keywords

Caspases; Drug design; Inhibitor binding; Substrate specificity; X ray structure

Indexed keywords

ASPARTIC ACID; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL ALDEHYDE; CASPASE 8; CASPASE INHIBITOR; CYSTEINE PROTEINASE; FAS ANTIGEN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 0034622936     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4041     Document Type: Article

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