Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

Journal of Medicinal Chemistry

Volumn 45, Issue 23, 2002, Pages 5005-5022

  Choong, Ingrid C ^a   Lew, Willard ^a   Lee, Dennis ^a   Pham, Phuongly ^a   Burdett, Matthew T ^a   Lam, Joni W ^a   Wiesmann, Christian ^a   Luong, Tinh N ^a   Fahr, Bruce ^a   DeLano, Warren L ^a   McDowell, Robert S ^a   Allen, Darin A ^a   Erlanson, Daniel A ^a   Gordon, Eric M ^a   O'Brien, Tom ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3 INHIBITOR; SMALL MOLECULE TRANSPORT AGENT;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; ENZYME INHIBITION; MEDIATOR RELEASE; MOLECULAR MODEL; PROTEIN DEGRADATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ASPARTIC ACID; BENZOXAZOLES; BINDING SITES; CASPASE 3; CASPASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FLUORENES; HUMANS; PROTEIN BINDING; SALICYLIC ACIDS; SULFONAMIDES; THIOPHENES;

EID: 0037038325     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020230j     Document Type: Article

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