Aza-peptide epoxides: Potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases)

Biological Chemistry

Volumn 384, Issue 12, 2003, Pages 1613-1618

  James, Karen Ellis ^a   Götz, Marion G ^a   Caffrey, Conor R ^b   Hansell, Elizabeth ^b   Carter, Wendy ^c   Barrett, Alan J ^c   McKerrow, James H ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Aza asparagine; Clan CD enzymes; Cysteine protease; Epoxysuccinate; Irreversible inhibitor; Synthetic inhibitor

Indexed keywords

AMIDE; AMINO ACID; ASPARAGINE; ASPARAGINE ENDOPEPTIDASE; ASPARTIC PROTEINASE; CASPASE; CATHEPSIN B; CHYMOTRYPSIN; CYSTEINE PROTEINASE INHIBITOR; EPOXIDE; GRANZYME B; PAPAIN; PEPTIDE DERIVATIVE; PROTEINASE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLASSIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; INHIBITION KINETICS; KIDNEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SCHISTOSOMA MANSONI; STEREOCHEMISTRY; SWINE;

ANIMALS; AZA COMPOUNDS; COUMARINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; EPOXY COMPOUNDS; KIDNEY; KINETICS; OLIGOPEPTIDES; RECOMBINANT PROTEINS; SCHISTOSOMA MANSONI; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM; SWINE;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI; SUS SCROFA;

EID: 0347358966     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.179     Document Type: Article

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