The atomic-resolution structure of human caspase-8, a key activator of apoptosis

Structure

Volumn 7, Issue 9, 1999, Pages 1135-1143

  Watt, William ^a   Koeplinger, Kenneth A ^a   Mildner, Ana M ^a   Heinrikson, Robert L ^a   Tomasselli, Alfredo G ^a   Watenpaugh, Keith D ^a  

^a PFIZER INC   (United States)

Author keywords

Apoptosis; Caspase; Cysteine protease; Dithiane diol

Indexed keywords

CASPASE; ISOENZYME;

APOPTOSIS; ARTICLE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0006871386     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(99)80180-4     Document Type: Article

References (38)

1. 1. Nicholson, D.W. & Thornberry, N.A. (1997). Caspases: killer proteases. Trends Biochem. Sci. 22, 299-306.
2. 2. Cohen, G.M. (1997). Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
3. 3. Zhivotovsky, B., Burgess, D.H., Vanags, D.M. & Orrenius, S. (1997). Involvement of cellular proteolytic machinery in apoptosis. Biochem. Biophys. Res. Commun. 230, 481-488.
4. 4. Nagata, S. (1997). Apoptosis by death factor. Cell 8, 355-365.
5. 5. Cryns, V. & Yuan, J. (1998). Proteases to die for. Genes Dev. 12, 1551-1570.
6. 6. Stennicke, H.R. & Salvesen, G.S. (1998). Properties of caspases. Biochem. Biophys. Acta 1387, 17-31.
7. 7. Thornberry, N.A. & Lazebnik, Y. (1998). Caspases: enemies within. Science 281, 1312-1316.
8. 8. Denner, L. (1999). Caspases in apoptotic death. Exp. Opin. Inves. Drugs 8, 37-50.
9. 9. Takahashi, A. & Earnshaw, W.C. (1996). ICE-related proteases in apoptosis. Curr. Opin. Genet. Dev. 6, 50-55.
10. 10. Chinnayan, A.C. & Dixit, V.M. (1996). The cell death machine. Curr. Biol. 6, 555-562.
11. 2 homodimer. Cell 78, 343-352.
12. 12. Wilson, K.P., et al., & Livingston, D.J. (1994). Structure and mechanism of interleukin-1β converting enzyme. Nature 370, 270-275.
13. 13. Rotonda, J., et al., & Becker, J.W. (1996). The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat. Struct. Biol. 3, 619-625.
14. 14. Mittl, P.R.E., et al., & Grutter, M.G. (1997). Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. J. Biol. Chem. 272, 6539-6547.
15. 15. Stennicke, H.R., et al., & Salvesen, G.S. (1998). Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 273, 27084-27090.
16. 16. Muzio, M., et al., & Dixit, V.M. (1996). FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD-95 (Fas/Apo-1) death-inducing signaling complex. Cell 85, 817-827.
17. 17. Medema, J.P., et al., & Peter, M.E. (1997). FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16, 2794-2804.
18. 18. Ashkenazi, A. & Dixit, V.M. (1998). Death receptors: signaling and modulation. Science 281, 1305-1308.
19. 19. Holtzman, D.M. & Deshmukh, M. (1997). Caspases: a treatment target for neurodegenerative disease? Nat. Med. 3, 954-955.
20. 20. Cotman C.W. & Anderson A.J. (1995). A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10, 19-45.
21. 21. Johnson, E.M., Jr. (1994). Possible role of neuronal apoptosis in Alzheimer's disease. Neurobiol. Aging 15, S187-S189.
22. 22. Bode, W. & Huber, R. (1992). Natural protein proteinase inhibitors and their interaction with proteinases. Eur. J. Biochem. 204, 433-451.
23. 13C NMR study of the stereospecificity of the thiohemiacetals formed on inhibition of papain by specific enantiomeric aldehydes. Biochemistry 25, 2293-2298.
24. 24. Menard, R., et al., & Storer, A.C. (1991). Contribution of the glutamine 19 side chain to transition-state stabilization in the oxyanion hole of papain. Biochemistry 30, 8924-8928.
25. 25. Thornberry, N.A., et al., & Nicholson, D.W. (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. J. Biol. Chem. 272, 17907-17911.
26. 26. McPherson, A. (1989). In Preparation and Analysis of Protein Crystals. (McPherson, A., ed.), pp. 94-97, Kreiger Publishing Co., Malabar, FL.
27. 27. SMART Software Reference Manual. (1998). Bruker Analytical X-ray Systems, Madison, WI.
28. 28. SAINT Software Reference Manual. (1998). Bruker Analytical X-ray Systems, Madison, WI.
29. 29. Collaborative Computational Project No. 4. (1994). The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760-763.
30. 30. Nazava, J. (1994). AMoRe: an automated package for molecular replacement. Acta Crystallogr. A 50, 157-163.
31. 31. Finzel, B.C. (1987). Incorporation of fast Fourier transforms to speed restrained least-squares refinement of protein structures. J. Appl. Crystallogr. 20, 53-55.
32. 32. Sheldrick, G.M. & Schneider, T.R. (1997). SHELXL: high resolution refinement. Methods Enzymol. 277, 319-343.
33. 33. Sack, J.S. & Quiocho, F.A. (1992). CHAIN crystallographic modeling program, Baylor College of Medicine, Houston, TX.
34. 34. Finzel, B.C. (1995). Mastering the LORE of protein structure. Acta Crystallogr. D 51, 450-457.
35. 35. Laskowski, R.A., MacArthur, M.W., Moss, D.S. & Thornton, J.M. (1993). PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283-291.
36. 36. Kraulis, P.J. (1991 ). MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.
37. 37. Nicholls, A., Sharp, K.A. & Honig, B. (1991 ). Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296.
38. 38. Weiner, S.J., Kollman, P.A., Nguyen, D.T. & Case, D.A. (1986). An all atom force field for simulations of proteins and nucleic acids. J. Comp. Chem. 7, 230-252.