Dicer is essential for formation of the heterochromatin structure in vertebrate cells

Nature Cell Biology

Volumn 6, Issue 8, 2004, Pages 784-791

  Fukagawa, Tatsuo ^a   Nogami, Masahiro ^a   Yoshikawa, Mitsuko ^a   Ikeno, Masashi ^b   Okazaki, Tuneko ^b   Takami, Yasunari ^c   Nakayama, Tatsuo ^c   Oshimura, Mitsuo ^d  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; COHESIN; CORE PROTEIN; DICER; DOUBLE STRANDED RNA; MUTANT PROTEIN; NUCLEASE; REPETITIVE DNA; SATELLITE DNA; UNCLASSIFIED DRUG; BUB1 SPINDLE CHECKPOINT PROTEIN; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE; RAD21 PROTEIN, HUMAN; RIBONUCLEASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CENTROMERE; CHICKEN; CHROMATIN STRUCTURE; CHROMOSOME 21; CONTROLLED STUDY; DNA SEQUENCE; GENETIC TRANSCRIPTION; HETEROCHROMATIN; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SISTER CHROMATID; VERTEBRATE; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; CHEMISTRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE SILENCING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PHYSIOLOGY; RESTRICTION MAPPING; TRANSGENE; WESTERN BLOTTING;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE; CELL SURVIVAL; CENTROMERE; CHICKENS; CHROMOSOMES, HUMAN, PAIR 21; ENDORIBONUCLEASES; GENE SILENCING; HETEROCHROMATIN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MODELS, BIOLOGICAL; MUTATION; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN KINASES; RESTRICTION MAPPING; RNA INTERFERENCE; TRANSGENES;

EID: 4143149753     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1155     Document Type: Article

References (29)

1. Hannon, G. J. RNA interference. Nature 418, 244-251 (2002).
2. Provost, P. et al. Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc. Natl Acad. Sci. USA 99, 16648-16653 (2002).
3. Hall, I. M., Noma, K. & Grewal, S. I. S. RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc. Natl Acad. Sci. USA 100, 193-198 (2003).
4. Volpe, T. et al. RNA interference is required for normal centromere function in fission yeast. Chromosome Res. 11, 137-146 (2003).
5. Choo, K. H. A. The Centromere. (Oxford University Press, Oxford, UK, 1997).
6. Hudson, D. F., Morrison, C., Ruchaud, S. & Earnshaw, W. C. Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'. Trends Cell Biol. 12, 281-287 (2002).
7. Bernstein, E. et al. Dicer is essential for mouse development. Nature Genet. 35, 215-217 (2003).
8. Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
9. Ikeno, M., Masumoto, H. & Okazaki, T. Distribution of CENP-B boxes reflected in CREST centromere antigenic sites on long-range a-satellite DNA arrays of human chromosome 21. Hum. Mol. Genet. 3, 1245-1257 (1994).
10. Ikeno, M. et al. Construction of YAC-based mammalian artificial chromosomes. Nature Biotech. 16, 431-439 (1998).
11. Brown, W. R., Hubbard, S. J., Tickle,, C. & Wilson SA. The chicken as a model for large-scale analysis of vertebrate gene function. Nature Rev. Genet. 4, 87-98 (2003).
12. Sonoda, E. et al. Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev. Cell 1, 759-770 (2001).
13. Partridge, J. F., Borgstrom, B. & Allshire, R. C. Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev. 14, 783-791 (2000).
14. Scueler, M. G., Higgins, A. W., Rudd, M. K., Gustashaw, K. & Willard, H. F. Genomic and genetic definition of a functional human centromere. Science 294, 109-115 (2001).
15. Sullivan, B. A. Centromere round-up at heterochromatin corral. Trends Biotech. 20, 80-92 (2002).
16. Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833-1837 (2002).
17. Schramke, V. & Allshire, R. Hairpin RNAs and retrotransposon LTRs effect RNAi and chromosome-based gene silencing. Science 301, 1069-1074 (2003).
18. Spence, J. M. et al. Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X α-satellite array. EMBO J. 21, 5269-5280 (2002).
19. Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Jayerzat, J.-P. & Allshire, R. C. Requirement of heterochromatin for cohesion at centromeres. Science 294, 2539-2542 (2001).
20. Nonaka, N. et al. Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nature Cell Biol. 4, 89-93 (2002).
21. Hayakawa, T., Haraguchi, T., Masumoto, H. & Hiraoka Y. Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase. J. Cell Sci. 116, 3327-3338 (2003).
22. Nakayama, J., Rice, J. C., Strahl, B. D., Allis, C. D. & Grewal, S. I. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110-113 (2001).
23. Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
24. Blower, M. D, Sullivan, B. A. & Karpen, G. H. Conserved organization of centromeric chomatin in flies and humans. Dev. Cell 2, 319-330 (2002).
25. Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi Machinery. Science 303, 669-672 (2004).
26. Fukagawa, T. et al. CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells. EMBO J. 20, 4603-4617 (2001).
27. Fukagawa, T. & Brown, W. R. A. Efficient conditional mutation of the vertebrate CENP-C gene. Hum. Mol. Genet. 6, 2301-2308 (1997).
28. Nishihashi et al. CENP-1 is essential for centromere function in vertebrate cells. Dev. Cell 2, 463-476 (2002).
29. Fukagawa, T., Pendon, C., Morris, J. & Brown, W. CENP-C is necessary but not sufficient to induce formation of a functional centromere. EMBO J. 18, 4196-4209 (1999).