Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

Science

Volumn 301, Issue 5636, 2003, Pages 1069-1074

  Schramke, Vera ^a   Allshire, Robin ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DNA; GENES; YEAST;

GENE SILENCING;

RNA;

CLR4 HISTONE METHYLTRANSFERASE; COHESIN; DNA; MESSENGER RNA; METHYLTRANSFERASE; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

GENE; RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMATIN CONDENSATION; CHROMATIN STRUCTURE; DNA METHYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SILENCING; GENE TARGETING; LONG TERMINAL REPEAT; NONHUMAN; PLANT; PRIORITY JOURNAL; RETROPOSON; RNA ANALYSIS; RNA DEGRADATION; RNA INTERFERENCE; RNA PROCESSING; RNA STRUCTURE; YEAST;

CELL CYCLE PROTEINS; CHROMATIN; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; HETEROCHROMATIN; MEIOSIS; METHYLTRANSFERASES; MICRORNAS; MODELS, GENETIC; NUCLEIC ACID CONFORMATION; RETROELEMENTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION, GENETIC;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 0042831010     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086870     Document Type: Article

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56. We thank members of the Allshire lab for advice and suggestions; A. Pidoux, A. Bird, and N. Hastie for comments on the manuscript; T. Volpe and R. Martienssen for strains and discussions; A. Hamilton and M. Matzke for siRNA detection protocols. We are grateful to V. Wood and H. Levin for communicating data before publication. R.A. also thanks members of the Epigenetic Regulation Network (EC HPRN-CT-2000-00078) for valuable input especially T. Jenuwein for antiserum for methyl H3. This research is supported by the Wellcome Trust. R.A. is a Wellcome Trust Principal Research Fellow.