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Volumn 3, Issue 7, 2004, Pages 884-892

p73 and p63: Why do we still need them?

Author keywords

Evolution; p53; p63; p73; Transcription

Indexed keywords

CELL PROTEIN; MESSENGER RNA; PROTEIN P53; PROTEIN P63; PROTEIN P73; TUMOR SUPPRESSOR PROTEIN;

EID: 13144295009     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.7.996     Document Type: Review
Times cited : (42)

References (150)
  • 1
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: The cell's response to p53. Nat Rev Cancer 2002; 2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 2
    • 0030884751 scopus 로고    scopus 로고
    • A novel protein with strong homology to the tumor suppressor p53
    • Schmale H, Bamberger C. A novel protein with strong homology to the tumor suppressor p53. Oncogene 1997; 15:1363-7.
    • (1997) Oncogene , vol.15 , pp. 1363-1367
    • Schmale, H.1    Bamberger, C.2
  • 3
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90:809-19.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3    Creancier, L.4    Biscan, J.C.5    Valent, A.6
  • 4
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2:305-16.
    • (1998) Mol Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6
  • 5
    • 0034064630 scopus 로고    scopus 로고
    • c-Abl: Activation and nuclear targets
    • Shaul Y. c-Abl: Activation and nuclear targets. Cell Death Differ 2000; 7:10-6.
    • (2000) Cell Death Differ , vol.7 , pp. 10-16
    • Shaul, Y.1
  • 6
    • 0033387525 scopus 로고    scopus 로고
    • Structure and function in the p53 family
    • Arrowsmith CH. Structure and function in the p53 family. Cell Death Differ 1999; 6:1169-73.
    • (1999) Cell Death Differ , vol.6 , pp. 1169-1173
    • Arrowsmith, C.H.1
  • 7
    • 0036468523 scopus 로고    scopus 로고
    • On the shoulders of giants: P63, p73 and the rise of p53
    • Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: P63, p73 and the rise of p53. Trends Genet 2002; 18:90-5.
    • (2002) Trends Genet , vol.18 , pp. 90-95
    • Yang, A.1    Kaghad, M.2    Caput, D.3    McKeon, F.4
  • 8
    • 0033552641 scopus 로고    scopus 로고
    • The p53 gene family
    • Kaelin Jr WG. The p53 gene family. Oncogene 1999; 18:7701-5.
    • (1999) Oncogene , vol.18 , pp. 7701-7705
    • Kaelin Jr., W.G.1
  • 10
    • 0034927749 scopus 로고    scopus 로고
    • p53 family update: P73 and p63 develop their own identities
    • Irwin MS, Kaelin WG. p53 family update: P73 and p63 develop their own identities. Cell Growth Differ 2001; 12:337-49.
    • (2001) Cell Growth Differ , vol.12 , pp. 337-349
    • Irwin, M.S.1    Kaelin, W.G.2
  • 12
    • 0034517534 scopus 로고    scopus 로고
    • Evolution of functions within the p53/p63/p73 family
    • De Laurenzi V, Melino G. Evolution of functions within the p53/p63/p73 family. Ann N Y Acad Sci 2000; 926:90-100.
    • (2000) Ann N Y Acad Sci , vol.926 , pp. 90-100
    • De Laurenzi, V.1    Melino, G.2
  • 13
    • 0642375803 scopus 로고    scopus 로고
    • p73 and p63 protein stability: The way to regulate function?
    • Maisse C, Guerrieri P, Melino G. p73 and p63 protein stability: The way to regulate function? Biochem Pharmacol 2003; 66:1555-61.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1555-1561
    • Maisse, C.1    Guerrieri, P.2    Melino, G.3
  • 15
    • 1242318518 scopus 로고    scopus 로고
    • p53 protein variants: Structural and functional similarities with p63 and p73 isoforms
    • Courtois S, de Fromentel CC, Hainaut P. p53 protein variants: Structural and functional similarities with p63 and p73 isoforms. Oncogene 2004; 23:631-8.
    • (2004) Oncogene , vol.23 , pp. 631-638
    • Courtois, S.1    De Fromentel, C.C.2    Hainaut, P.3
  • 17
    • 0033381054 scopus 로고    scopus 로고
    • Regulation and activation of p53 and its family members
    • Lohrum MA, Vousden KH. Regulation and activation of p53 and its family members. Cell Death Differ 1999; 6:1162-8.
    • (1999) Cell Death Differ , vol.6 , pp. 1162-1168
    • Lohrum, M.A.1    Vousden, K.H.2
  • 18
    • 0036125352 scopus 로고    scopus 로고
    • Role of p73 in malignancy: Tumor suppressor or oncogene?
    • Stiewe T, Putzer BM. Role of p73 in malignancy: Tumor suppressor or oncogene? Cell Death Differ 2002; 9:237-45.
    • (2002) Cell Death Differ , vol.9 , pp. 237-245
    • Stiewe, T.1    Putzer, B.M.2
  • 20
    • 0035966345 scopus 로고    scopus 로고
    • p53, p63 and p73-solos, alliances and feuds among family members
    • Moll UM, Erster S, Zaika A. p53, p63 and p73-solos, alliances and feuds among family members. Biochim Biophys Acta 2001; 1552:47-59.
    • (2001) Biochim Biophys Acta , vol.1552 , pp. 47-59
    • Moll, U.M.1    Erster, S.2    Zaika, A.3
  • 21
    • 0033379005 scopus 로고    scopus 로고
    • p53 family genes: Structural comparison, expression and mutation
    • Ikawa S, Nakagawara A, Ikawa Y. p53 family genes: Structural comparison, expression and mutation. Cell Death Differ 1999; 6:1154-61.
    • (1999) Cell Death Differ , vol.6 , pp. 1154-1161
    • Ikawa, S.1    Nakagawara, A.2    Ikawa, Y.3
  • 22
    • 0042634489 scopus 로고    scopus 로고
    • p53 mutations and resistance to chemotherapy: A stab in the back for p73
    • Soussi T. p53 mutations and resistance to chemotherapy: A stab in the back for p73. Cancer Cell 2003; 3:303-5.
    • (2003) Cancer Cell , vol.3 , pp. 303-305
    • Soussi, T.1
  • 23
    • 0036561484 scopus 로고    scopus 로고
    • p53 leans on its siblings
    • Urist M, Prives C. p53 leans on its siblings. Cancer Cell 2002; 1:311-3.
    • (2002) Cancer Cell , vol.1 , pp. 311-313
    • Urist, M.1    Prives, C.2
  • 24
    • 0034079520 scopus 로고    scopus 로고
    • The p53/p63/p73 family of transcription factors: Overlapping and distinct functions
    • Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: Overlapping and distinct functions. J Cell Sci 2000; 113:1661-70.
    • (2000) J Cell Sci , vol.113 , pp. 1661-1670
    • Levrero, M.1    De Laurenzi, V.2    Costanzo, A.3    Gong, J.4    Wang, J.Y.5    Melino, G.6
  • 26
    • 0035082243 scopus 로고    scopus 로고
    • Role of the newer p53 family proteins in malignancy
    • Irwin MS, Kaelin Jr WG. Role of the newer p53 family proteins in malignancy. Apoptosis 2001; 6:17-29.
    • (2001) Apoptosis , vol.6 , pp. 17-29
    • Irwin, M.S.1    Kaelin Jr., W.G.2
  • 28
    • 0032479083 scopus 로고    scopus 로고
    • Another p53 Doppelganger?
    • Kaelin Jr WG. Another p53 Doppelganger? Science 1998; 281:57-8.
    • (1998) Science , vol.281 , pp. 57-58
    • Kaelin Jr., W.G.1
  • 29
    • 0344766067 scopus 로고    scopus 로고
    • The emerging p53 gene family
    • Kaelin Jr WG. The emerging p53 gene family. J Natl Cancer Inst 1999; 91:594-8.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 594-598
    • Kaelin Jr., W.G.1
  • 31
    • 1642377359 scopus 로고    scopus 로고
    • p63 and the epithelial stem cell: More than status quo?
    • McKeon F. p63 and the epithelial stem cell: More than status quo? Genes Dev 2004; 18:465-9.
    • (2004) Genes Dev , vol.18 , pp. 465-469
    • McKeon, F.1
  • 33
    • 1342305505 scopus 로고    scopus 로고
    • p73, the "assistant" guardian of the genome?
    • Melino G. p73, the "assistant" guardian of the genome? Ann N Y Acad Sci 2003; 1010:9-15.
    • (2003) Ann N Y Acad Sci , vol.1010 , pp. 9-15
    • Melino, G.1
  • 34
    • 0030866516 scopus 로고    scopus 로고
    • Lonely no more: P53 finds its kin in a tumor suppressor haven
    • Oren M. Lonely no more: P53 finds its kin in a tumor suppressor haven. Cell 1997; 90:829-32.
    • (1997) Cell , vol.90 , pp. 829-832
    • Oren, M.1
  • 36
    • 0033600267 scopus 로고    scopus 로고
    • DNA damage enables p73
    • White E, Prives C. DNA damage enables p73. Nature 1999; 399:734-5, 737.
    • (1999) Nature , vol.399 , pp. 734-735
    • White, E.1    Prives, C.2
  • 37
    • 0034576495 scopus 로고    scopus 로고
    • p63 and p73: P53 mimics, menaces and more
    • Yang A, McKeon F. p63 and p73: P53 mimics, menaces and more. Nat Rev Mol Cell Biol 2000; 1:199-207.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 199-207
    • Yang, A.1    McKeon, F.2
  • 38
    • 0032053793 scopus 로고    scopus 로고
    • Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers
    • Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res 1998; 58:1380-3.
    • (1998) Cancer Res , vol.58 , pp. 1380-1383
    • Nomoto, S.1    Haruki, N.2    Kondo, M.3    Konishi, H.4    Takahashi, T.5
  • 39
    • 13144293030 scopus 로고    scopus 로고
    • Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas
    • Sunahara M, Ichimiya S, Nimura Y, Takada N, Sakiyama S, Sato Y, et al. Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. Int J Oncol 1998; 13:319-23.
    • (1998) Int J Oncol , vol.13 , pp. 319-323
    • Sunahara, M.1    Ichimiya, S.2    Nimura, Y.3    Takada, N.4    Sakiyama, S.5    Sato, Y.6
  • 40
    • 0032523842 scopus 로고    scopus 로고
    • Mutation allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma
    • Takahashi H, Ichimiya S, Nimura Y, Watanabe M, Furusato M, Wakui S, et al. Mutation allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res 1998; 58:2076-7.
    • (1998) Cancer Res , vol.58 , pp. 2076-2077
    • Takahashi, H.1    Ichimiya, S.2    Nimura, Y.3    Watanabe, M.4    Furusato, M.5    Wakui, S.6
  • 41
    • 0032407889 scopus 로고    scopus 로고
    • The large T antigen of simian virus 40 binds and inactivates p53 but not p73
    • Dobbelstein M, Roth J. The large T antigen of simian virus 40 binds and inactivates p53 but not p73. J Gen Virol 1998; 79:3079-83.
    • (1998) J Gen Virol , vol.79 , pp. 3079-3083
    • Dobbelstein, M.1    Roth, J.2
  • 43
    • 0031596434 scopus 로고    scopus 로고
    • p73, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells
    • Prabhu NS, Somasundaram K, Saryamoorthy K, Herlyn M, El-Deiry WS. p73, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. Int J Oncol 1998; 13:5-9.
    • (1998) Int J Oncol , vol.13 , pp. 5-9
    • Prabhu, N.S.1    Somasundaram, K.2    Saryamoorthy, K.3    Herlyn, M.4    El-Deiry, W.S.5
  • 44
    • 0032939936 scopus 로고    scopus 로고
    • The yeast two-hybrid system reveals no interaction between p73 α and SV40 large T-antigen
    • Reichelt M, Zang KD, Seifert M, Welter C, Ruffing T. The yeast two-hybrid system reveals no interaction between p73 α and SV40 large T-antigen. Arch Virol 1999; 144:621-6.
    • (1999) Arch Virol , vol.144 , pp. 621-626
    • Reichelt, M.1    Zang, K.D.2    Seifert, M.3    Welter, C.4    Ruffing, T.5
  • 45
    • 0031661779 scopus 로고    scopus 로고
    • Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins
    • Roth J, König C, Wienzek S, Weigel S, Ristea S, Dobbelstein M. Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins. J Virol 1998; 72:8510-8516.
    • (1998) J Virol , vol.72 , pp. 8510-8516
    • Roth, J.1    König, C.2    Wienzek, S.3    Weigel, S.4    Ristea, S.5    Dobbelstein, M.6
  • 46
    • 0032724420 scopus 로고    scopus 로고
    • Failure of viral oncoproteins to target the p53-homologue p51A
    • Roth J, Dobbelstein M. Failure of viral oncoproteins to target the p53-homologue p51A. J Gen Virol 1999; 80:3251-5.
    • (1999) J Gen Virol , vol.80 , pp. 3251-3255
    • Roth, J.1    Dobbelstein, M.2
  • 47
    • 0032933627 scopus 로고    scopus 로고
    • Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and e4orf6 proteins
    • Steegenga WT, Shvarts A, Riteco N, Bos JL, Jochemsen AG. Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and e4orf6 proteins. Mol Cell Biol 1999; 19:3885-94.
    • (1999) Mol Cell Biol , vol.19 , pp. 3885-3894
    • Steegenga, W.T.1    Shvarts, A.2    Riteco, N.3    Bos, J.L.4    Jochemsen, A.G.5
  • 48
    • 0033989602 scopus 로고    scopus 로고
    • E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53
    • Wienzek S, Roth J, Dobbelstein M. E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53. J Virol 2000; 74:193-202.
    • (2000) J Virol , vol.74 , pp. 193-202
    • Wienzek, S.1    Roth, J.2    Dobbelstein, M.3
  • 50
    • 17544363909 scopus 로고    scopus 로고
    • p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    • Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2000; 404:99-103.
    • (2000) Nature , vol.404 , pp. 99-103
    • Yang, A.1    Walker, N.2    Bronson, R.3    Kaghad, M.4    Oosterwegel, M.5    Bonnin, J.6
  • 51
    • 0033594485 scopus 로고    scopus 로고
    • p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999; 398:714-8.
    • (1999) Nature , vol.398 , pp. 714-718
    • Yang, A.1    Schweitzer, R.2    Sun, D.3    Kaghad, M.4    Walker, N.5    Bronson, R.T.6
  • 52
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. Regulation of the specific DNA binding function of p53. Cell 1992; 71:875-86.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 53
    • 0037130473 scopus 로고    scopus 로고
    • p53 induces the expression of its antagonist p73 ΔN, establishing an autoregulatory feedback loop
    • Kartasheva NN, Contente A, Lenz-Stoppler C, Roth J, Dobbelstein M. p53 induces the expression of its antagonist p73 ΔN, establishing an autoregulatory feedback loop. Oncogene 2002; 21:4715-27.
    • (2002) Oncogene , vol.21 , pp. 4715-4727
    • Kartasheva, N.N.1    Contente, A.2    Lenz-Stoppler, C.3    Roth, J.4    Dobbelstein, M.5
  • 54
    • 0035813165 scopus 로고    scopus 로고
    • High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53
    • Klein C, Georges G, Kunkele KP, Huber R, Engh RA, Hansen S. High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. J Biol Chem 2001; 276:37390-401.
    • (2001) J Biol Chem , vol.276 , pp. 37390-37401
    • Klein, C.1    Georges, G.2    Kunkele, K.P.3    Huber, R.4    Engh, R.A.5    Hansen, S.6
  • 55
    • 0010009604 scopus 로고    scopus 로고
    • Transactivation-deficient ΔTA-p73 inhibits p53 by direct competition for DNA-binding: Implications for tumorigenesis
    • Stiewe T, Theseling CC, Putzer BM. Transactivation-deficient ΔTA-p73 inhibits p53 by direct competition for DNA-binding: Implications for tumorigenesis. J Biol Chem 2002; 13:13.
    • (2002) J Biol Chem , vol.13 , pp. 13
    • Stiewe, T.1    Theseling, C.C.2    Putzer, B.M.3
  • 58
    • 0037015397 scopus 로고    scopus 로고
    • ΔN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
    • Courrois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U, et al. ΔN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 2002; 21:6722-8.
    • (2002) Oncogene , vol.21 , pp. 6722-6728
    • Courrois, S.1    Verhaegh, G.2    North, S.3    Luciani, M.G.4    Lassus, P.5    Hibner, U.6
  • 59
    • 0032543608 scopus 로고    scopus 로고
    • Activation of p53 DNA binding activity by point mutation
    • Marston NJ, Ludwig RL, Vousden KH. Activation of p53 DNA binding activity by point mutation. Oncogene 1998; 16:3123-31.
    • (1998) Oncogene , vol.16 , pp. 3123-3131
    • Marston, N.J.1    Ludwig, R.L.2    Vousden, K.H.3
  • 60
    • 0344196904 scopus 로고    scopus 로고
    • SAM domains: Uniform structure, diversity of function
    • Kim CA, Bowie JU. SAM domains: Uniform structure, diversity of function. Trends Biochem Sci 2003; 28:625-8.
    • (2003) Trends Biochem Sci , vol.28 , pp. 625-628
    • Kim, C.A.1    Bowie, J.U.2
  • 62
    • 0036096302 scopus 로고    scopus 로고
    • Mutations in the p53 homolog p63: Allele-speciftc developmental syndromes in humans
    • van Bokhoven H, McKeon F. Mutations in the p53 homolog p63: Allele-speciftc developmental syndromes in humans. Trends Mol Med 2002; 8:133-9.
    • (2002) Trends Mol Med , vol.8 , pp. 133-139
    • Van Bokhoven, H.1    McKeon, F.2
  • 63
    • 0036892018 scopus 로고    scopus 로고
    • Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains
    • Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L. Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains. Mol Cell Biol 2002; 22:8659-68.
    • (2002) Mol Cell Biol , vol.22 , pp. 8659-8668
    • Ghioni, P.1    Bolognese, F.2    Duijf, P.H.3    Van Bokhoven, H.4    Mantovani, R.5    Guerrini, L.6
  • 64
    • 0041382829 scopus 로고    scopus 로고
    • A dance between interferon-α/β and p53 demonstrates collaborations in tumor suppression and antiviral activities
    • Pestka S. A dance between interferon-α/β and p53 demonstrates collaborations in tumor suppression and antiviral activities. Cancer Cell 2003; 4:85-7.
    • (2003) Cancer Cell , vol.4 , pp. 85-87
    • Pestka, S.1
  • 65
    • 0041662272 scopus 로고    scopus 로고
    • Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
    • Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H, et al. Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003; 424:516-23.
    • (2003) Nature , vol.424 , pp. 516-523
    • Takaoka, A.1    Hayakawa, S.2    Yanai, H.3    Stoiber, D.4    Negishi, H.5    Kikuchi, H.6
  • 66
    • 0036094734 scopus 로고    scopus 로고
    • The human p73 promoter: Characterization and identification of functional E2F binding sites
    • Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin Jr WG, Liu W. The human p73 promoter: Characterization and identification of functional E2F binding sites. Neoplasia 2002; 4:195-203.
    • (2002) Neoplasia , vol.4 , pp. 195-203
    • Seelan, R.S.1    Irwin, M.2    Van Der Stoop, P.3    Qian, C.4    Kaelin Jr., W.G.5    Liu, W.6
  • 68
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe T, Putzer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet 2000; 26:464-9.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Stiewe, T.1    Putzer, B.M.2
  • 69
    • 0035815677 scopus 로고    scopus 로고
    • Oncogenes induce and activate endogenous p73 protein
    • Zaika A, Irwin M, Sansome C, Moll UM. Oncogenes induce and activate endogenous p73 protein. J Biol Chem 2001; 276:11310-6.
    • (2001) J Biol Chem , vol.276 , pp. 11310-11316
    • Zaika, A.1    Irwin, M.2    Sansome, C.3    Moll, U.M.4
  • 71
    • 0036203514 scopus 로고    scopus 로고
    • Auto inhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter
    • Nakagawa T, Takahashi M, Ozaki T, Watanabe Ki K, Todo S, Mizuguchi H, et al. Auto inhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter. Mol Cell Biol 2002; 22:2575-85.
    • (2002) Mol Cell Biol , vol.22 , pp. 2575-2585
    • Nakagawa, T.1    Takahashi, M.2    Ozaki, T.3    Watanabe Ki, K.4    Todo, S.5    Mizuguchi, H.6
  • 72
    • 0042337365 scopus 로고    scopus 로고
    • Differential regulation of p63 and p73 expression
    • Waltermann A, Kartasheva NN, Dobbelstein M. Differential regulation of p63 and p73 expression. Oncogene 2003; 22:5686-93.
    • (2003) Oncogene , vol.22 , pp. 5686-5693
    • Waltermann, A.1    Kartasheva, N.N.2    Dobbelstein, M.3
  • 73
    • 0035193044 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation
    • Fontemaggi G, Gurtner A, Strano S, Higashi Y, Sacchi A, Piaggio G, et al. The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation. Mol Cell Biol 2001; 21:8461-70.
    • (2001) Mol Cell Biol , vol.21 , pp. 8461-8470
    • Fontemaggi, G.1    Gurtner, A.2    Strano, S.3    Higashi, Y.4    Sacchi, A.5    Piaggio, G.6
  • 74
    • 0022773059 scopus 로고
    • Immunologically distinct p53 molecules generated by alternative splicing
    • Arai N, Nomura D, Yokota K, Wolf D, Brill E, Shohat O, et al. Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol 1986; 6:3232-9.
    • (1986) Mol Cell Biol , vol.6 , pp. 3232-3239
    • Arai, N.1    Nomura, D.2    Yokota, K.3    Wolf, D.4    Brill, E.5    Shohat, O.6
  • 75
    • 0028915813 scopus 로고
    • Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
    • Wu L, Bayle JH, Elenbaas B, Pavlerich NP, Levine AJ. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids. Mol Cell Biol 1995; 15:497-504.
    • (1995) Mol Cell Biol , vol.15 , pp. 497-504
    • Wu, L.1    Bayle, J.H.2    Elenbaas, B.3    Pavlerich, N.P.4    Levine, A.J.5
  • 76
    • 0029078067 scopus 로고
    • The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
    • Bayle JH, Elenbaas B, Levine AJ. The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity. Proc Natl Acad Sci USA 1995; 92:5729-33.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5729-5733
    • Bayle, J.H.1    Elenbaas, B.2    Levine, A.J.3
  • 77
    • 0033864175 scopus 로고    scopus 로고
    • Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours
    • Zwahlen D, Tschan MP, Grob TJ, Peters UR, Fink D, Haenggi W, et al. Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours. Int J Cancer 2000; 88:66-70.
    • (2000) Int J Cancer , vol.88 , pp. 66-70
    • Zwahlen, D.1    Tschan, M.P.2    Grob, T.J.3    Peters, U.R.4    Fink, D.5    Haenggi, W.6
  • 78
    • 0033168066 scopus 로고    scopus 로고
    • Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
    • Zaika AI, Kovalev S, Marchenko ND, Moll UM. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res 1999; 59:3257-63.
    • (1999) Cancer Res , vol.59 , pp. 3257-3263
    • Zaika, A.I.1    Kovalev, S.2    Marchenko, N.D.3    Moll, U.M.4
  • 79
    • 1942467065 scopus 로고    scopus 로고
    • Genomic variants in exons and introns. Identifying the splicing spoilers
    • Pagani F, Baralle FE. Genomic variants in exons and introns. Identifying the splicing spoilers. Nat Rev Genetics 2004; 5:389-96.
    • (2004) Nat Rev Genetics , vol.5 , pp. 389-396
    • Pagani, F.1    Baralle, F.E.2
  • 81
    • 0033603494 scopus 로고    scopus 로고
    • p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    • Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J Biol Chem 1999; 274:18709-14.
    • (1999) J Biol Chem , vol.274 , pp. 18709-18714
    • Davison, T.S.1    Vagner, C.2    Kaghad, M.3    Ayed, A.4    Caput, D.5    Arrowsmith, C.H.6
  • 83
    • 2342446704 scopus 로고    scopus 로고
    • p73-mediated chemosensitivity: A preferential target of oncogenic mutant p53
    • Strano S, Blandino G. p73-mediated chemosensitivity: A preferential target of oncogenic mutant p53. Cell Cycle 2003; 2:348-9.
    • (2003) Cell Cycle , vol.2 , pp. 348-349
    • Strano, S.1    Blandino, G.2
  • 84
    • 18544364361 scopus 로고    scopus 로고
    • Physical interaction with human tumor-derived p53 mutants inhibits p63 activities
    • Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A, et al. Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. J Biol Chem 2002; 277:18817-26.
    • (2002) J Biol Chem , vol.277 , pp. 18817-18826
    • Strano, S.1    Fontemaggi, G.2    Costanzo, A.3    Rizzo, M.G.4    Monti, O.5    Baccarini, A.6
  • 85
    • 0034703044 scopus 로고    scopus 로고
    • Physical and functional interaction between p53 mutants and different isoforms of p73
    • Strano S, Munarriz E, Rossi M, Cristofanelli B, Shaul Y, Castagnoli L, et al. Physical and functional interaction between p53 mutants and different isoforms of p73. J Biol Chem 2000; 275:29503-12.
    • (2000) J Biol Chem , vol.275 , pp. 29503-29512
    • Strano, S.1    Munarriz, E.2    Rossi, M.3    Cristofanelli, B.4    Shaul, Y.5    Castagnoli, L.6
  • 86
    • 0037041392 scopus 로고    scopus 로고
    • p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002; 416:560-4.
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3    Sengupta, S.4    Yang, A.5    McKeon, F.6
  • 87
    • 0033959744 scopus 로고    scopus 로고
    • MDM2-master regulator of the p53 tumor suppressor protein
    • Momand J, Wu HH, Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene 2000; 242:15-29.
    • (2000) Gene , vol.242 , pp. 15-29
    • Momand, J.1    Wu, H.H.2    Dasgupta, G.3
  • 88
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 1996; 274:948-53.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6
  • 89
    • 0033536230 scopus 로고    scopus 로고
    • Mdm2 binds p73 α without targeting degradation
    • Balint E, Bates S, Vousden KH. Mdm2 binds p73 α without targeting degradation. Oncogene 1999; 18:3923-9.
    • (1999) Oncogene , vol.18 , pp. 3923-3929
    • Balint, E.1    Bates, S.2    Vousden, K.H.3
  • 90
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
    • Dobbelstein M, Wienzek S, König C, Roth J. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 1999; 18:2101-6.
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1    Wienzek, S.2    König, C.3    Roth, J.4
  • 91
    • 0032961828 scopus 로고    scopus 로고
    • MDM2 suppresses p73 function without promoting p73 degradation
    • Zeng X, Chen L, Jost CA, Maya R, Keller D, Wang X, et al. MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol 1999; 19:3257-66.
    • (1999) Mol Cell Biol , vol.19 , pp. 3257-3266
    • Zeng, X.1    Chen, L.2    Jost, C.A.3    Maya, R.4    Keller, D.5    Wang, X.6
  • 92
    • 0037169519 scopus 로고    scopus 로고
    • The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
    • Calabro V, Mansueto G, Parisi T, Vivo M, Calogero RA, La Mantia G. The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. J Biol Chem 2002; 277:2674-81.
    • (2002) J Biol Chem , vol.277 , pp. 2674-2681
    • Calabro, V.1    Mansueto, G.2    Parisi, T.3    Vivo, M.4    Calogero, R.A.5    La Mantia, G.6
  • 93
    • 0035805487 scopus 로고    scopus 로고
    • Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    • Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem 2001; 276:15164-73.
    • (2001) J Biol Chem , vol.276 , pp. 15164-15173
    • Strano, S.1    Munarriz, E.2    Rossi, M.3    Castagnoli, L.4    Shaul, Y.5    Sacchi, A.6
  • 94
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 2003; 11:11-23.
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 96
    • 0032417530 scopus 로고    scopus 로고
    • Adenovirus e4orf6 oncoprotein modulates the function of the p53-related protein, p73
    • Higashino F, Pipas JM, Shenk T. Adenovirus e4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc Natl Acad Sci USA 1998; 95:15683-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15683-15687
    • Higashino, F.1    Pipas, J.M.2    Shenk, T.3
  • 97
    • 0035158586 scopus 로고    scopus 로고
    • Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex
    • Querido E, Morrison MR, Chu-Pham-Dang H, Thirlwell SW, Boivin D, Branton PE, et al. Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex. J Virol 2001; 75:699-709.
    • (2001) J Virol , vol.75 , pp. 699-709
    • Querido, E.1    Morrison, M.R.2    Chu-Pham-Dang, H.3    Thirlwell, S.W.4    Boivin, D.5    Branton, P.E.6
  • 98
    • 0037737758 scopus 로고    scopus 로고
    • Regulation of p53 responses by post-translational modifications
    • Xu Y. Regulation of p53 responses by post-translational modifications. Cell Death Differ 2003; 10:400-3.
    • (2003) Cell Death Differ , vol.10 , pp. 400-403
    • Xu, Y.1
  • 99
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: Life, death and cancer. Cell Death Differ 2003; 10:431-42.
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 100
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 2003; 15:164-71.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 101
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73α and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature 1999; 399:809-13.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 102
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin Jr WG, Levrero M, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399:806-9.
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Yang, H.Q.3    Melino, G.4    Kaelin Jr., W.G.5    Levrero, M.6
  • 103
    • 0033600235 scopus 로고    scopus 로고
    • p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999; 399:814-7.
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.M.1    Shioya, H.2    Ishiko, T.3    Sun, X.4    Gu, J.5    Huang, Y.Y.6
  • 104
    • 18244408596 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    • Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole PA, et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell 2002; 9:175-86.
    • (2002) Mol Cell , vol.9 , pp. 175-186
    • Costanzo, A.1    Merlo, P.2    Pediconi, N.3    Fulco, M.4    Sartorelli, V.5    Cole, P.A.6
  • 105
    • 0037044799 scopus 로고    scopus 로고
    • Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses
    • Fontemaggi G, Kela I, Amariglio N, Rechavi G, Krishnamurthy J, Strano S, et al. Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem 2002; 277:43359-68.
    • (2002) J Biol Chem , vol.277 , pp. 43359-43368
    • Fontemaggi, G.1    Kela, I.2    Amariglio, N.3    Rechavi, G.4    Krishnamurthy, J.5    Strano, S.6
  • 106
    • 0036352550 scopus 로고    scopus 로고
    • p53 gene family p51(p63)-encoded, secondary transactivator p51B(TAp63α) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation
    • Okada Y, Osada M, Kurata S, Sato S, Aisaki K, Kageyama Y, et al. p53 gene family p51(p63)-encoded, secondary transactivator p51B(TAp63α) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation. Exp Cell Res 2002; 276:194-200.
    • (2002) Exp Cell Res , vol.276 , pp. 194-200
    • Okada, Y.1    Osada, M.2    Kurata, S.3    Sato, S.4    Aisaki, K.5    Kageyama, Y.6
  • 107
    • 0034702133 scopus 로고    scopus 로고
    • p51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation
    • Katoh I, Aisaki KI, Kurata SI, Ikawa S, Ikawa Y. p51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation. Oncogene 2000; 19:3126-30.
    • (2000) Oncogene , vol.19 , pp. 3126-3130
    • Katoh, I.1    Aisaki, K.I.2    Kurata, S.I.3    Ikawa, S.4    Ikawa, Y.5
  • 108
    • 0032951530 scopus 로고    scopus 로고
    • p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol 1999; 19:1438-49.
    • (1999) Mol Cell Biol , vol.19 , pp. 1438-1449
    • Di Como, C.J.1    Gaiddon, C.2    Prives, C.3
  • 109
    • 10744230945 scopus 로고    scopus 로고
    • p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003; 3:387-402.
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1    Gasco, M.2    Hiller, L.3    Sullivan, A.4    Syed, N.5    Trigiante, G.6
  • 110
    • 0035131701 scopus 로고    scopus 로고
    • A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
    • Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001; 21:1874-87.
    • (2001) Mol Cell Biol , vol.21 , pp. 1874-1887
    • Gaiddon, C.1    Lokshin, M.2    Ahn, J.3    Zhang, T.4    Prives, C.5
  • 111
    • 0242664079 scopus 로고    scopus 로고
    • p73α regulation by Chk1 in response to DNA damage
    • Gonzalez S, Prives C, Cordon-Cardo C. p73α regulation by Chk1 in response to DNA damage. Mol Cell Biol 2003; 23:8161-71.
    • (2003) Mol Cell Biol , vol.23 , pp. 8161-8171
    • Gonzalez, S.1    Prives, C.2    Cordon-Cardo, C.3
  • 113
    • 0042347445 scopus 로고    scopus 로고
    • Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73
    • Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler JP, et al. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem 2003; 278:27421-31.
    • (2003) J Biol Chem , vol.278 , pp. 27421-27431
    • Gaiddon, C.1    Lokshin, M.2    Gross, I.3    Levasseur, D.4    Taya, Y.5    Loeffler, J.P.6
  • 115
    • 0035966316 scopus 로고    scopus 로고
    • Why is p53 acetylated?
    • Prives C, Manley JL. Why is p53 acetylated? Cell 2001; 107:815-8.
    • (2001) Cell , vol.107 , pp. 815-818
    • Prives, C.1    Manley, J.L.2
  • 116
    • 0031710479 scopus 로고    scopus 로고
    • The INK4a/ARF tumor suppressor. One gene-two products-two pathways
    • Chin L, Pomerantz J, DePinho RA. The INK4a/ARF tumor suppressor. One gene-two products-two pathways. Trends Biochem Sci 1998; 23:291-6.
    • (1998) Trends Biochem Sci , vol.23 , pp. 291-296
    • Chin, L.1    Pomerantz, J.2    DePinho, R.A.3
  • 117
    • 0242721592 scopus 로고    scopus 로고
    • Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    • Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, et al. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol 2003; 23:8902-12.
    • (2003) Mol Cell Biol , vol.23 , pp. 8902-8912
    • Zhang, Y.1    Wolf, G.W.2    Bhat, K.3    Jin, A.4    Allio, T.5    Burkhart, W.A.6
  • 120
    • 0034680441 scopus 로고    scopus 로고
    • Covalent modification of p73α by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif
    • Minty A, Dumont X, Kaghad M, Caput D. Covalent modification of p73α by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J Biol Chem 2000; 275:36316-23.
    • (2000) J Biol Chem , vol.275 , pp. 36316-36323
    • Minty, A.1    Dumont, X.2    Kaghad, M.3    Caput, D.4
  • 122
    • 0027248782 scopus 로고
    • Sequence-specific DNA binding by p53: Identification of target sites and lack of binding to p53 - MDM2 complexes
    • Zauberman A, Barak Y, Ragimov N, Levy N, Oren M. Sequence-specific DNA binding by p53: Identification of target sites and lack of binding to p53 - MDM2 complexes. EMBO J 1993; 12:2799-808.
    • (1993) EMBO J , vol.12 , pp. 2799-2808
    • Zauberman, A.1    Barak, Y.2    Ragimov, N.3    Levy, N.4    Oren, M.5
  • 125
    • 0038190875 scopus 로고    scopus 로고
    • Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73
    • Stiewe T, Stanelle J, Theseling CC, Pollmeier B, Beitzinger M, Putzer BM. Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73. J Biol Chem 2003; 278:14230-6.
    • (2003) J Biol Chem , vol.278 , pp. 14230-14236
    • Stiewe, T.1    Stanelle, J.2    Theseling, C.C.3    Pollmeier, B.4    Beitzinger, M.5    Putzer, B.M.6
  • 126
    • 1642430935 scopus 로고    scopus 로고
    • Wnt breakers in colon cancer
    • Clevers H. Wnt breakers in colon cancer. Cancer Cell 2004; 5:5-6.
    • (2004) Cancer Cell , vol.5 , pp. 5-6
    • Clevers, H.1
  • 128
    • 0942301281 scopus 로고    scopus 로고
    • p63 is the molecular switch for initiation of an epithelial stratification program
    • Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 2004; 18:126-31.
    • (2004) Genes Dev , vol.18 , pp. 126-131
    • Koster, M.I.1    Kim, S.2    Mills, A.A.3    DeMayo, F.J.4    Roop, D.R.5
  • 129
    • 4644248840 scopus 로고    scopus 로고
    • Transgenic mouse models provide new insights into the role of p63 in epidermal development
    • Koster MI, Roop DR. Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle 2004; 3:411-3.
    • (2004) Cell Cycle , vol.3 , pp. 411-413
    • Koster, M.I.1    Roop, D.R.2
  • 130
  • 131
    • 0032744735 scopus 로고    scopus 로고
    • Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
    • Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, Smits AP, et al. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 1999; 99:143-53.
    • (1999) Cell , vol.99 , pp. 143-153
    • Celli, J.1    Duijf, P.2    Hamel, B.C.3    Bamshad, M.4    Kramer, B.5    Smits, A.P.6
  • 132
    • 0036538566 scopus 로고    scopus 로고
    • Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63
    • Duijf PH, Vanmolkot KR, Propping P, Friedl W, Krieger E, McKeon F, et al. Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Hum Mol Genet 2002; 11:799-804.
    • (2002) Hum Mol Genet , vol.11 , pp. 799-804
    • Duijf, P.H.1    Vanmolkot, K.R.2    Propping, P.3    Friedl, W.4    Krieger, E.5    McKeon, F.6
  • 133
    • 0036863624 scopus 로고    scopus 로고
    • REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
    • Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 2002; 10:995-1005.
    • (2002) Mol Cell , vol.10 , pp. 995-1005
    • Ellisen, L.W.1    Ramsayer, K.D.2    Johannessen, C.M.3    Yang, A.4    Beppu, H.5    Minda, K.6
  • 134
    • 0036791211 scopus 로고    scopus 로고
    • Split hand/split foot, iris/choroid coloboma, hypospadias and subfertility: A new developmental malformation syndrome?
    • Giltay JC, Wittebol-Post D, van Bokhoven H, Kastrop PM, Lock MT. Split hand/split foot, iris/choroid coloboma, hypospadias and subfertility: A new developmental malformation syndrome? Clin Dysmorphol 2002; 11:231-5.
    • (2002) Clin Dysmorphol , vol.11 , pp. 231-235
    • Giltay, J.C.1    Wittebol-Post, D.2    Van Bokhoven, H.3    Kastrop, P.M.4    Lock, M.T.5
  • 135
    • 0034892604 scopus 로고    scopus 로고
    • p63 gene mutations in eec syndrome limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation
    • van Bokhoven H, Hamel BC, Bamshad M, Sangiorgi E, Gurrieri F, Duijf PH, et al. p63 Gene mutations in eec syndrome limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. Am J Hum Genet 2001; 69:481-92.
    • (2001) Am J Hum Genet , vol.69 , pp. 481-492
    • Van Bokhoven, H.1    Hamel, B.C.2    Bamshad, M.3    Sangiorgi, E.4    Gurrieri, F.5    Duijf, P.H.6
  • 137
    • 0031766420 scopus 로고    scopus 로고
    • Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
    • Kovalev S, Marchenko N, Swendeman S, LaQuaglia M, Moll UM. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ 1998; 9:897-903.
    • (1998) Cell Growth Differ , vol.9 , pp. 897-903
    • Kovalev, S.1    Marchenko, N.2    Swendeman, S.3    LaQuaglia, M.4    Moll, U.M.5
  • 138
    • 0033199888 scopus 로고    scopus 로고
    • Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers
    • Hagiwara K, McMenamin MG, Miura K, Harris CC. Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. Cancer Res 1999; 59:4165-9.
    • (1999) Cancer Res , vol.59 , pp. 4165-4169
    • Hagiwara, K.1    McMenamin, M.G.2    Miura, K.3    Harris, C.C.4
  • 139
    • 0033451039 scopus 로고    scopus 로고
    • Mutation and transcription analyses of the p63 gene in cervical carcinoma
    • Nishi H, Isaka K, Sagawa Y, Usuda S, Fujito A, Ito H, et al. Mutation and transcription analyses of the p63 gene in cervical carcinoma. Int J Oncol 1999; 15:1149-53.
    • (1999) Int J Oncol , vol.15 , pp. 1149-1153
    • Nishi, H.1    Isaka, K.2    Sagawa, Y.3    Usuda, S.4    Fujito, A.5    Ito, H.6
  • 142
  • 144
    • 11144357549 scopus 로고    scopus 로고
    • Transdominant ΔTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo
    • Concin N, Becker K, Slade N, Erster S, Mueller-Holzner E, Ulmer H, et al. Transdominant ΔTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Cancer Res 2004; 64:2449-60.
    • (2004) Cancer Res , vol.64 , pp. 2449-2460
    • Concin, N.1    Becker, K.2    Slade, N.3    Erster, S.4    Mueller-Holzner, E.5    Ulmer, H.6
  • 147
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 2004; 6:443-50.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 148
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • Dumont P, Leu JI, Della Pietra III AC, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 2003; 33:357-65.
    • (2003) Nat Genet , vol.33 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della Pietra III, A.C.3    George, D.L.4    Murphy, M.5
  • 149
    • 0037238101 scopus 로고    scopus 로고
    • Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
    • Campisi J. Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes. Exp Gerontol 2003; 38:5-11.
    • (2003) Exp Gerontol , vol.38 , pp. 5-11
    • Campisi, J.1
  • 150
    • 0037119631 scopus 로고    scopus 로고
    • ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
    • Zaika AI, Slade N, Erster SH, Sansome C, Joseph TW, Pearl M, et al. ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med 2002; 196:765-80.
    • (2002) J Exp Med , vol.196 , pp. 765-780
    • Zaika, A.I.1    Slade, N.2    Erster, S.H.3    Sansome, C.4    Joseph, T.W.5    Pearl, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.