메뉴 건너뛰기




Volumn 28, Issue 12, 2003, Pages 663-670

Functional regulation of p73 and p63: Development and cancer

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P63; PROTEIN P73;

EID: 0345059168     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2003.10.004     Document Type: Review
Times cited : (261)

References (73)
  • 1
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M., et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 90:1997;809-819.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1
  • 2
    • 0032161624 scopus 로고    scopus 로고
    • P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A., et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell. 2:1998;305-316.
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1
  • 3
    • 17544363909 scopus 로고    scopus 로고
    • P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    • Yang A., et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 404:2000;99-103.
    • (2000) Nature , vol.404 , pp. 99-103
    • Yang, A.1
  • 4
    • 0037112245 scopus 로고    scopus 로고
    • P73 is required for survival and maintenance of CNS neurons
    • Pozniak C.D., et al. p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22:2002;9800-9809.
    • (2002) J. Neurosci. , vol.22 , pp. 9800-9809
    • Pozniak, C.D.1
  • 5
    • 0033594485 scopus 로고    scopus 로고
    • P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • Yang A., et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 398:1999;714-718.
    • (1999) Nature , vol.398 , pp. 714-718
    • Yang, A.1
  • 6
    • 0033594491 scopus 로고    scopus 로고
    • P63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills A.A., et al. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 398:1999;708-713.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1
  • 7
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer. 2:2002;594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 8
    • 0034685798 scopus 로고    scopus 로고
    • Induction of neuronal differentiation by p73, in a neuroblastoma cell line
    • De Laurenzi V., et al. Induction of neuronal differentiation by p73, in a neuroblastoma cell line. J. Biol. Chem. 275:2000;15226-15231.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15226-15231
    • De Laurenzi, V.1
  • 9
    • 0036468523 scopus 로고    scopus 로고
    • On the shoulders of giants: P63, p73 and the rise of p53
    • Yang A., et al. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 18:2002;90-95.
    • (2002) Trends Genet. , vol.18 , pp. 90-95
    • Yang, A.1
  • 10
    • 0036674502 scopus 로고    scopus 로고
    • P73: Friend or foe in tumorigenesis
    • Melino G., et al. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer. 2:2002;605-615.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 605-615
    • Melino, G.1
  • 11
    • 0032476743 scopus 로고    scopus 로고
    • Two new p73 splice variants, γ and δ, with different transcriptional activity
    • De Laurenzi V., et al. Two new p73 splice variants, γ and δ, with different transcriptional activity. J. Exp. Med. 188:1998;1763-1768.
    • (1998) J. Exp. Med. , vol.188 , pp. 1763-1768
    • De Laurenzi, V.1
  • 12
    • 0032990811 scopus 로고    scopus 로고
    • Additional complexity in p73: Induction by mitogens in lymphoid cells and identification of two new splicing variants e and z
    • De Laurenzi V., et al. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants e and z. Cell Death Differ. 6:1999;389-390.
    • (1999) Cell Death Differ. , vol.6 , pp. 389-390
    • De Laurenzi, V.1
  • 13
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu S., et al. Akt phosphorylates the yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol. Cell. 11:2003;11-23.
    • (2003) Mol. Cell , vol.11 , pp. 11-23
    • Basu, S.1
  • 14
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin M., et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 407:2000;645-648.
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1
  • 15
    • 0034063604 scopus 로고    scopus 로고
    • A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
    • Marin M.C., et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 25:2000;47-54.
    • (2000) Nat. Genet. , vol.25 , pp. 47-54
    • Marin, M.C.1
  • 16
    • 85030927679 scopus 로고    scopus 로고
    • Binding of the C-terminal SAM domain of human p73 to lipid membranes
    • in press
    • Barrera, F.N. et al. Binding of the C-terminal SAM domain of human p73 to lipid membranes. J. Biol. Chem. (in press).
    • J. Biol. Chem.
    • Barrera, F.N.1
  • 17
    • 18244402691 scopus 로고    scopus 로고
    • Human Δnp73 regulates a dominant negative feedback loop for TA p73 and p53
    • Grob T.J., et al. Human ΔNp73 regulates a dominant negative feedback loop for TA p73 and p53. Cell Death Differ. 8:2001;1213-1223.
    • (2001) Cell Death Differ. , vol.8 , pp. 1213-1223
    • Grob, T.J.1
  • 18
    • 0042337365 scopus 로고    scopus 로고
    • Differential regulation of p63 and p73 expression
    • Waltermann A., et al. Differential regulation of p63 and p73 expression. Oncogene. 22:2003;5686-5693.
    • (2003) Oncogene , vol.22 , pp. 5686-5693
    • Waltermann, A.1
  • 19
    • 0036005908 scopus 로고    scopus 로고
    • Expression of Δnp73 is a molecular marker for adverse outcome in neuroblastoma patients
    • Casciano I., et al. Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients. Cell Death Differ. 9:2002;246-251.
    • (2002) Cell Death Differ. , vol.9 , pp. 246-251
    • Casciano, I.1
  • 20
    • 0037119631 scopus 로고    scopus 로고
    • Δnp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
    • Zaika A.I., et al. ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J. Exp. Med. 196:2002;765-780.
    • (2002) J. Exp. Med. , vol.196 , pp. 765-780
    • Zaika, A.I.1
  • 21
    • 10744230945 scopus 로고    scopus 로고
    • P53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D., et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell. 3:2003;387-402.
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1
  • 22
    • 0037041392 scopus 로고    scopus 로고
    • P63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • Flores E.R., et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 416:2002;560-564.
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1
  • 23
    • 0037177836 scopus 로고    scopus 로고
    • Nuclear import and export signals in control of the p53-related protein p73
    • Inoue T., et al. Nuclear import and export signals in control of the p53-related protein p73. J. Biol. Chem. 277:2002;15053-15060.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15053-15060
    • Inoue, T.1
  • 24
    • 0033595124 scopus 로고    scopus 로고
    • Promoter specificity and stability control of the p53-related protein p73
    • Lee C.W., La Thangue N.B. Promoter specificity and stability control of the p53-related protein p73. Oncogene. 18:1999;4171-4181.
    • (1999) Oncogene , vol.18 , pp. 4171-4181
    • Lee, C.W.1    La Thangue, N.B.2
  • 25
    • 0345570517 scopus 로고    scopus 로고
    • Identification of Daxx interacting with p73, one of the p53 family and its regulation of p53 activity by competitive interaction with PML
    • Kim E.J., et al. Identification of Daxx interacting with p73, one of the p53 family and its regulation of p53 activity by competitive interaction with PML. Nucleic Acids Res. 31:2003;5356-5367.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 5356-5367
    • Kim, E.J.1
  • 26
    • 0035845848 scopus 로고    scopus 로고
    • Amphiphysin IIb-1, a novel splicing variant of amphiphysin II, regulates p73β function through protein-protein interactions
    • Kim K.C., et al. Amphiphysin IIb-1, a novel splicing variant of amphiphysin II, regulates p73β function through protein-protein interactions. Oncogene. 20:2001;6689-6699.
    • (2001) Oncogene , vol.20 , pp. 6689-6699
    • Kim, K.C.1
  • 27
    • 0041589272 scopus 로고    scopus 로고
    • Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function
    • Vella V., et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J. Biol. Chem. 278:2003;25151-25157.
    • (2003) J. Biol. Chem. , vol.278 , pp. 25151-25157
    • Vella, V.1
  • 28
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73α and their collaboration to induce apoptosis
    • Agami R., et al. Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature. 399:1999;809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1
  • 29
    • 0033600235 scopus 로고    scopus 로고
    • P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Yuan Z.M., et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 399:1999;814-817.
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.M.1
  • 30
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong J., et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399:1999;806-809.
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.1
  • 31
    • 85047696046 scopus 로고    scopus 로고
    • Regulation of p73 by c-Abl through the p38 MAP kinase pathway
    • Sanchez-Prieto R., et al. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene. 21:2002;974-979.
    • (2002) Oncogene , vol.21 , pp. 974-979
    • Sanchez-Prieto, R.1
  • 32
    • 0042347445 scopus 로고    scopus 로고
    • Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle dependent manner and negatively regulate p73
    • Gaiddon C., et al. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle dependent manner and negatively regulate p73. J. Biol. Chem. 278:2003;27421-27431.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27421-27431
    • Gaiddon, C.1
  • 33
    • 18644384283 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
    • Zacchi P., et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 419:2002;853-857.
    • (2002) Nature , vol.419 , pp. 853-857
    • Zacchi, P.1
  • 34
    • 18244408596 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    • Costanzo A., et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell. 9:2002;175-186.
    • (2002) Mol. Cell , vol.9 , pp. 175-186
    • Costanzo, A.1
  • 35
    • 17944379798 scopus 로고    scopus 로고
    • ASPP proteins specifically stimulate the apoptotic function of p53
    • Samuels-Lev Y., et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell. 8:2001;781-794.
    • (2001) Mol. Cell , vol.8 , pp. 781-794
    • Samuels-Lev, Y.1
  • 36
    • 0034616344 scopus 로고    scopus 로고
    • Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions
    • Scharnhorst V., et al. Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions. J. Biol. Chem. 275:2000;10202-10211.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10202-10211
    • Scharnhorst, V.1
  • 37
    • 0037026606 scopus 로고    scopus 로고
    • The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21 (CIP1/Waf1)
    • Budram-Mahadeo V., et al. The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21 (CIP1/Waf1). Oncogene. 21:2002;6123-6131.
    • (2002) Oncogene , vol.21 , pp. 6123-6131
    • Budram-Mahadeo, V.1
  • 38
    • 0038641906 scopus 로고    scopus 로고
    • Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
    • Uramoto H., et al. Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. Biochem. J. 371:2003;301-310.
    • (2003) Biochem. J. , vol.371 , pp. 301-310
    • Uramoto, H.1
  • 39
    • 0033536230 scopus 로고    scopus 로고
    • Mdm2 binds p73α without targeting degradation
    • Balint E., et al. Mdm2 binds p73α without targeting degradation. Oncogene. 18:1999;3923-3929.
    • (1999) Oncogene , vol.18 , pp. 3923-3929
    • Balint, E.1
  • 40
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
    • Dobbelstein M., et al. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene. 18:1999;2101-2106.
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1
  • 41
    • 0033615084 scopus 로고    scopus 로고
    • MDM2 and MDMX bind and stabilize the p53-related protein p73
    • Ongkeko W.M., et al. MDM2 and MDMX bind and stabilize the p53-related protein p73. Curr. Biol. 9:1999;829-832.
    • (1999) Curr. Biol. , vol.9 , pp. 829-832
    • Ongkeko, W.M.1
  • 42
    • 0034921151 scopus 로고    scopus 로고
    • Regulation of p63 function by Mdm2 and MdmX
    • Kadakia M., et al. Regulation of p63 function by Mdm2 and MdmX. DNA Cell Biol. 20:2001;321-330.
    • (2001) DNA Cell Biol. , vol.20 , pp. 321-330
    • Kadakia, M.1
  • 43
    • 0035958574 scopus 로고    scopus 로고
    • Hdmx and Mdm2 can repress transcription activation by p53 but not by p63
    • Little N.A., Jochemsen A.G. Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene. 20:2001;4576-4580.
    • (2001) Oncogene , vol.20 , pp. 4576-4580
    • Little, N.A.1    Jochemsen, A.G.2
  • 44
    • 0037169519 scopus 로고    scopus 로고
    • The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
    • Calabro V., et al. The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. J. Biol. Chem. 277:2002;2674-2681.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2674-2681
    • Calabro, V.1
  • 45
    • 0036510750 scopus 로고    scopus 로고
    • HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter
    • Stros M., et al. HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J. Biol. Chem. 277:2002;7157-7164.
    • (2002) J. Biol. Chem. , vol.277 , pp. 7157-7164
    • Stros, M.1
  • 46
    • 0344284564 scopus 로고    scopus 로고
    • Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
    • Shimodaira H., et al. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc. Natl. Acad. Sci. U. S. A. 100:2003;2420-2425.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 2420-2425
    • Shimodaira, H.1
  • 47
    • 0037200046 scopus 로고    scopus 로고
    • P73 interacts with c-Myc to regulate Y-box-binding protein-1 expression
    • Uramoto H., et al. p73 interacts with c-Myc to regulate Y-box-binding protein-1 expression. J. Biol. Chem. 277:2002;31694-31702.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31694-31702
    • Uramoto, H.1
  • 48
    • 0037177834 scopus 로고    scopus 로고
    • Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function
    • Watanabe K., et al. Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function. J. Biol. Chem. 277:2002;15113-15123.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15113-15123
    • Watanabe, K.1
  • 49
    • 0037456995 scopus 로고    scopus 로고
    • Modulation of p53 and p73 levels by cyclin G: Implication of a negative feedback regulation
    • Ohtsuka T., et al. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene. 22:2003;1678-1687.
    • (2003) Oncogene , vol.22 , pp. 1678-1687
    • Ohtsuka, T.1
  • 50
    • 0037107374 scopus 로고    scopus 로고
    • SSRP1 functions as a co-activator of the transcriptional activator p63
    • Zeng S.X., et al. SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J. 21:2002;5487-5497.
    • (2002) EMBO J. , vol.21 , pp. 5487-5497
    • Zeng, S.X.1
  • 51
    • 18744406283 scopus 로고    scopus 로고
    • A C-terminal inhibitory domain controls the activity of p63 by intramolecular mechanisms
    • Serber Z., et al. A C-terminal inhibitory domain controls the activity of p63 by intramolecular mechanisms. Mol. Cell. Biol. 22:2002;8601-8611.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8601-8611
    • Serber, Z.1
  • 52
    • 0036892018 scopus 로고    scopus 로고
    • Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains
    • Ghioni P., et al. Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol. Cell. Biol. 22:2002;8659-8668.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8659-8668
    • Ghioni, P.1
  • 53
    • 0034743628 scopus 로고    scopus 로고
    • P63α and Δnp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
    • Dohn M., et al. p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene. 20:2001;3193-3205.
    • (2001) Oncogene , vol.20 , pp. 3193-3205
    • Dohn, M.1
  • 54
    • 0035852688 scopus 로고    scopus 로고
    • P53 associates with and targets Δnp63 into a protein degradation pathway
    • Ratovistski E., et al. p53 associates with and targets ΔNp63 into a protein degradation pathway. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1817-1822.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 1817-1822
    • Ratovistski, E.1
  • 55
    • 19044363045 scopus 로고    scopus 로고
    • Δnp63 induces β-catenin nuclear accumulation and signalling
    • Patturajan M., et al. ΔNp63 induces β-catenin nuclear accumulation and signalling. Cancer Cell. 1:2002;369-379.
    • (2002) Cancer Cell , vol.1 , pp. 369-379
    • Patturajan, M.1
  • 56
    • 0037507296 scopus 로고    scopus 로고
    • Δnp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development
    • Wu G., et al. ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 63:2003;2351-2357.
    • (2003) Cancer Res. , vol.63 , pp. 2351-2357
    • Wu, G.1
  • 57
    • 0037445901 scopus 로고    scopus 로고
    • E2F and cell cycle control: A double edged sword
    • Stevens C., La Thangue N.B. E2F and cell cycle control: a double edged sword. Arch. Biochem. Biophys. 412:2003;157-169.
    • (2003) Arch. Biochem. Biophys. , vol.412 , pp. 157-169
    • Stevens, C.1    La Thangue, N.B.2
  • 58
    • 0038142184 scopus 로고    scopus 로고
    • Differential regulation of E2F1 apoptotic target genes in response to DNA damage
    • Pediconi N., et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat. Cell Biol. 5:2003;552-558.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 552-558
    • Pediconi, N.1
  • 59
    • 85030925160 scopus 로고    scopus 로고
    • P73 is regulated by phosphorylation at the G2/M transition
    • in press
    • Fulco, M. et al. p73 is regulated by phosphorylation at the G2/M transition. J. Biol. Chem. (in press).
    • J. Biol. Chem.
    • Fulco, M.1
  • 60
    • 0038751809 scopus 로고    scopus 로고
    • Increased Δn-p73 expression in tumours by upregulation of the E2F1-regulated, TA-promoter-derived Δn′-p73 transcript
    • Putzer B.M., et al. Increased ΔN-p73 expression in tumours by upregulation of the E2F1-regulated, TA-promoter-derived ΔN′-p73 transcript. Cell Death Differ. 10:2003;612-614.
    • (2003) Cell Death Differ. , vol.10 , pp. 612-614
    • Putzer, B.M.1
  • 61
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 113:2003;703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1
  • 62
    • 0042929916 scopus 로고    scopus 로고
    • PRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73
    • Alexander K., et al. pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73. Mol. Cancer Res. 1:2003;716-728.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 716-728
    • Alexander, K.1
  • 63
    • 0033571275 scopus 로고    scopus 로고
    • Comparative analysis of p73 and p53 regulation and effector functions
    • Fang L., et al. Comparative analysis of p73 and p53 regulation and effector functions. J. Cell Biol. 147:1999;823-830.
    • (1999) J. Cell Biol. , vol.147 , pp. 823-830
    • Fang, L.1
  • 64
    • 0035855628 scopus 로고    scopus 로고
    • P53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
    • Jung M.S., et al. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene. 20:2001;5818-5825.
    • (2001) Oncogene , vol.20 , pp. 5818-5825
    • Jung, M.S.1
  • 65
    • 0038621377 scopus 로고    scopus 로고
    • Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB
    • Ozaki T., et al. Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB. Oncogene. 22:2003;3231-3242.
    • (2003) Oncogene , vol.22 , pp. 3231-3242
    • Ozaki, T.1
  • 66
    • 0041997348 scopus 로고    scopus 로고
    • Chemosensitivity linked to p73 function
    • Irwin M.S., et al. Chemosensitivity linked to p73 function. Cancer Cell. 3:2003;403-410.
    • (2003) Cancer Cell , vol.3 , pp. 403-410
    • Irwin, M.S.1
  • 67
    • 0035815677 scopus 로고    scopus 로고
    • Oncogenes induce and activate endogenous p73 protein
    • Zaika A., et al. Oncogenes induce and activate endogenous p73 protein. J. Biol. Chem. 276:2001;11310-11316.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11310-11316
    • Zaika, A.1
  • 68
    • 18244393811 scopus 로고    scopus 로고
    • E7 proteins from oncogenic human papillomavirus types transactivate p73: Role in cervical intraepithelial neoplasia
    • Brooks L.A., et al. E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. Br. J. Cancer. 86:2002;263-268.
    • (2002) Br. J. Cancer , vol.86 , pp. 263-268
    • Brooks, L.A.1
  • 69
    • 0033168066 scopus 로고    scopus 로고
    • Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
    • Zaika A.I., et al. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res. 59:1999;3257-3263.
    • (1999) Cancer Res. , vol.59 , pp. 3257-3263
    • Zaika, A.I.1
  • 70
    • 0032951530 scopus 로고    scopus 로고
    • P73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como C.J., et al. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol. Cell. Biol. 19:1999;1438-1449.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1438-1449
    • Di Como, C.J.1
  • 71
    • 0036911840 scopus 로고    scopus 로고
    • The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
    • Langerod A., et al. The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas. Cancer Epidemiol. Biomarkers Prev. 11:2002;1684-1688.
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , pp. 1684-1688
    • Langerod, A.1
  • 72
    • 0036096302 scopus 로고    scopus 로고
    • Mutations in the p53 homolog p63: Allele-specific developmental syndromes in humans
    • van Bokhoven H., McKeon F. Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol. Med. 8:2002;133-139.
    • (2002) Trends Mol. Med. , vol.8 , pp. 133-139
    • Van Bokhoven, H.1    McKeon, F.2
  • 73
    • 0038737074 scopus 로고    scopus 로고
    • P53 and TGF-β in development: Prelude to tumor suppression?
    • Whitman M., McKeon F. p53 and TGF-β in development: prelude to tumor suppression? Cell. 113:2003;275-280.
    • (2003) Cell , vol.113 , pp. 275-280
    • Whitman, M.1    McKeon, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.