Role of p73 in malignancy: Tumor suppressor or oncogene?

Cell Death and Differentiation

Volumn 9, Issue 3, 2002, Pages 237-245

  Stiewe, T ^a   Putzer B M ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Apoptosis; Oncogene; p53; p73; Tumor suppressor

Indexed keywords

DNA; ISOPROTEIN; PROTEIN P53; PROTEIN P73;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CHROMOSOME 1P; CONTROLLED STUDY; DNA DAMAGE; GENE ACTIVITY; GENE DELETION; GENE LOCATION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KNOCKOUT MOUSE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; RNA SPLICING; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; DNA-BINDING PROTEINS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; NEOPLASMS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0036125352     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400995     Document Type: Review

References (53)

1. Surfing the p53 network
2. p53 mutations in human cancers
3. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
4. A new human p53 homologue
5. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
6. p73 is a simian [correction of human] p53-related protein that can induce apoptosis
7. Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells
8. P63 and P73:P53 mimics, menaces and more
9. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
10. Two new p73 splice variants, gamma and delta, with different transcriptional activity
11. Additional complexity in p73: Induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta
12. Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma
13. Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines
14. Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53
15. Lack of p73 expression in mature B-ALL and identification of three new splicing variants restricted to pre B and C-ALL indicate a role of p73 in B cell ALL differentiation
16. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
17. Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells
18. Analysis of p73 in human borderline and invasive ovarian tumor
19. Comparative analysis of p73 and p53 regulation and effector functions
20. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
21. Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family
22. Promoter specificity and stability control of the p53-related protein p73
23. Identification and classification of p53-regulated genes
24. Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells
25. Transcriptional activities of p73 splicing variants are regulated by inter-variant association
26. Tumor spectrum analysis in p53-mutant mice
27. Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas
28. Fine mapping of distal 1p loci reveals TP73 at D1S468
29. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
30. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
31. Distinct expression patterns of the p53-homologue p73 in malignant and normal hematopoiesis assessed by a novel real-time reverse transcription-polymerase chain reaction assay and protein analysis
32. Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia
33. Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer
34. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
35. Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma
36. p73 is not mutated in meningiomas as determined with a functional yeast assay but p73 expression increases with tumor grade
37. Wild type p73 overexpression and high-grade malignancy in breast cancer
38. P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line
39. Tumor surveillance via the ARF-p53 pathway
40. Mdm2 binds p73 alpha without targeting degradation
41. MDM2 suppresses p73 function without promoting p73 degradation
42. Role of the p53-homologue p73 in E2F1-induced apoptosis
43. Role for the p53 homologue p73 in E2F-1-induced apoptosis
44. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
45. Oncogenes Induce and Activate Endogenous p73 Protein
46. E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products
47. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
48. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
49. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
50. Physical and functional interaction between p53 mutants and different isoforms of p73
51. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
52. Molecular alterations of p73 in human esophageal squamous cell carcinomas: Loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53
53. Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia