Wild type p73 overexpression and high-grade malignancy in breast cancer

Breast Cancer Research and Treatment

Volumn 66, Issue 3, 2001, Pages 183-190

  Dominguez, G ^a   Silva, J M ^a   Silva, J ^a   Garcia, J M ^a   Sanchez, A ^a   Navarro, A ^a   Gallego, I ^b   Provencio, M ^a   Espana P ^a   Bonilla, F ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b HOSPITAL UNIVERSITARIO SANTA CRISTINA   (Spain)

Author keywords

Breast cancer; p53 gene; p73 gene; p73 LOH; p73 overexpression

Indexed keywords

PROTEIN P53; PROTEIN P73;

ARTICLE; BREAST CARCINOMA; CANCER GRADING; CARCINOGENESIS; CONTROLLED STUDY; FROZEN SECTION; GENE MUTATION; GENE OVEREXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; BREAST NEOPLASMS; CARCINOMA; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MIDDLE AGED; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 0034917034     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010624717311     Document Type: Article

References (39)

1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
2. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
3. Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression
4. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.3 in human lung cancers
5. Allelic expression of p73 in human ovarian cancers
6. Mutational analysis of p73 gene localized at chromosome 1p36.3 in colorectal carcinomas
7. Mutational analysis of the p73 gene in human breast cancers
8. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
9. P73 is a human p53-related protein that can induce apoptosis
10. Viral oncoproteins discriminate between p53 and p53 homolog p73
11. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
12. Mutational and expression analysis of the p73 gene in melanoma cell lines
13. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
14. Distal deletion of chromosome 1p in ductal carcinoma of the breast
15. p73 mutations are not detected in sporadic and hereditary breast cancer
16. Infrequent somatic mutation of the p73 gene in various human cancers
17. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ Cpg island methylation
18. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
19. p73 competes with p53 and attenuates its response in a human ovarian cancer cell line
20. Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanomas
21. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
22. Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma
23. Overexpression of the wild type p73 gene in human bladder cancer
24. Elevated and biallelic expression of p73 is associated with progression of human bladder cancer
25. Activation of p73 silent allele in lung cancer
26. Mutation allelotyping and transcription analysis of the p73 gene in prostatic carcinoma
27. p73 a gene related to p53, is not mutated in esophageal carcinoma
28. Optimization of nonradioisotopic single strand conformation polymorphism analysis with a conventional minislab gel electrophoresis aparatus
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30. Cadherin-11 is expressed invasive breast cancer cell lines
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32. Two distinct regions involved in 1p deletion in human primary breast cancer
33. Detection of cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer
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35. Molecular alterations of p73 in human esophageal squamous cell carcinomas: Loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53
36. p73 is up-regulated in a subset of hepatocellular carcinomas
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38. Breast cancer
39. Malignant tumors of the breast