On the shoulders of giants: p63, p73 and the rise of p53

Trends in Genetics

Volumn 18, Issue 2, 2002, Pages 90-95

  Yang, Annie ^a   Kaghad, Mourad ^b   Caput, Daniel ^b   McKeon, Frank ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PROTEIN P53; PROTEIN P63; PROTEIN P73;

CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; EPITHELIUM CELL; HETEROZYGOSITY LOSS; HOMEOSTASIS; HUMAN; IMMUNITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TUMOR SUPPRESSOR GENE;

EID: 0036468523     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(02)02595-7     Document Type: Review

References (50)

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4. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing and dominant-negative activities
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6. A new human p53 homologue
7. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
8. A second p53-related protein, p73L, with high homology to p73
9. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
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11. p73 is a simian [correction of human] p53-related protein that can induce apoptosis
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16. Chasing the cancer demon
17. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
18. AIS is an oncogene amplified in squamous cell carcinoma
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21. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
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23. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
24. Role of the p53 homologue p73 in E2F-1-induced apoptosis
25. Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas
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30. Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells
31. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
32. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis
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35. p53 associates with and targets Delta Np63 into a protein degradation pathway
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48. Evidence for a clade of nematodes, arthropods and other moulting animals
49. Caenorhabditis elegans p53: Role in apoptosis, meiosis and stress resistance