p53 family genes: Structural comparison, expression and mutation

Cell Death and Differentiation

Volumn 6, Issue 12, 1999, Pages 1154-1161

  Ikawa, S ^a   Nakagawara, A ^b   Ikawa, Y ^c  

^a TOHOKU UNIVERSITY   (Japan)

^b CHIBA CANCER CENTER   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Mutation; p51 p63; p53 family genes; p73; Splice variants; Tissue specific expression

Indexed keywords

DACTINOMYCIN; DNA; DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN P53; PROTEIN P63; PROTEIN P73; UNCLASSIFIED DRUG;

ADENOCARCINOMA; APOPTOSIS; BRAIN; CELL DIFFERENTIATION; DNA DAMAGE; DNA LIBRARY; ERYTHROLEUKEMIA CELL; GENE EXPRESSION; GENE INDUCTION; GENE ISOLATION; GENE MUTATION; GENE STRUCTURE; GENOME IMPRINTING; HETEROZYGOSITY LOSS; LUNG NON SMALL CELL CANCER; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SKELETAL MUSCLE; TEMPERATURE SENSITIVE MUTANT; TISSUE SPECIFICITY; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

EID: 0033379005     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400631     Document Type: Review

References (48)

1. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A. Chalon P, Leilas JM, Dumont X, Ferrara P, McKeon F and Caput D (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90: 809-819.
2. Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M and Ikawa S (1998) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nature Medicine 4: 839-843.
3. Schmale H and Bambergeric C (1997) A novel protein with strong homology to the tumor suppressor p53. Oncogene 15: 1363-1367.
4. Trink B, Okami K, Wu L, Spiuranpong V, Jen J and Sidransky D (1998) A new human p53 homolog. Nature Medicine 4: 747-748.
5. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D and McKeon F (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2: 305-316.
6. Senoo M, Seiki N, Ohira M, Sugano S, Watanabe M, Tachibana M, Tanaka T, Shinkai Y and Kato H (1998) A second p53-related protein, p7L, with high homology to p73. Biochem. Biophys. Res. Commun. 248: 603-607.
7. De Laurenzi V, Constanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchaiarico-Petruzzelli M, Levrero M and Melino G (1998) Two new p73 splice variants, g and d, with different transcriptional activity. J. Exp. Med. 188: 1763-1768.
8. Tani M, Shimizu K, Kawahara C, Kohno T, Ishimoto O, Ikawa S and Yokota J (1999) Mutation and expression of the p51 gene in human lung cancer. Neoplasia 1: 71-79.
9. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, and Bradley A (1999) p63 is a homologue required for limb and epidermal morphogenesis. Nature 398: 708-713.
10. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C and McKeon F (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714-718.
11. Suda Y, Aizawa S, Furuta Y, Yagi T, Ikawa Y, Saitoh K, Yamada Y, Toyoshima K and Yamamoto Y (1990) Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659-Glu659). EMBO J. 9: 181-190.
12. Xu X, Yamamura Y, Tsukada T, Yoshida MA, Senda H, Nagayoshi M, Ikeuchi T and Ikawa Y (1995) A mouse erythroleukemia cell line possessing Friend spleen focus-forming virus gp55 transgene and temperature-sensitive mutant p53 gene. Jpn. J. Cancer Res. 86: 284-291.
13. Lo Cunsolo C, Casciano I, Banelli B, Tonini GP and Romani M (1998) Refined chromosomal localization of the putative tumor suppressor gene TP73. Cytogenet. Cell Genet. 82: 199-201.
14. Perri P, Prami C, Savelyeva L, Pillmann A and Schwab M (1999) Fine mapping of distal 1p loci reveals TP73 at D1S468. Cytogenet. Cell Genet. 84: 111-114.
15. Ichimiya S, Nimura Y, Kageyama H, Takada N, Sunahara M, Shishikura T, Nakamura Y, Sakiyama S, Seki N, Ohira M, Kaneko Y, McKeon F, Caput D and Nakagawara A (1999) p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene 18: 1061-1066.
16. Ejeskar K, Sjoberg R-M, Kogner P and Martinsson T (1999) Variable expression and absence of mutations in p73 in primary neuroblastoma tumors argues against a role in neuroblastoma development. Int. J. Mol. Med. 3: 585-589.
17. Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T, Takahashi T and Takahashi T (1998) Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res. 58: 1380-1383.
18. Yokozaki H, Shitara Y, Fujimoto JY, Hiyama T, Yasui W and Tahara E (1999) Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype. Int. J. Cancer 83: 192-196.
19. Imyanitov EN, Birrell GW, Filippovich I, Sorokina N, Arnold J, Mould MA, Wright K, Walsh M, Mok SC, Lavin MF, Chenevix-Trench G and Khanna KK (1999) Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target. Oncogene 18: 4640-4642.
20. Nimura Y, Mihara M, Ichimiya S, Sakiyama S, Seki N, Ohira M, Nomura N, Fujimori M, Adachi W, Amano J, He M, Ping Y-M and Nakagawara A (1998) p73, a gene related to p53, is not mutated in esophageal carcinomas. Int. J. Cancer 78: 437-440.
21. Takahashi H, Ichimiya S, Nimura Y, Watanabe M, Furusato M, Wakui S, Yatani R, Aizawa S and Nakagawara A (1998) Mutation, Allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res. 58: 2076-2077.
22. De Laurenzi V, Catani MV, Terrinoni A, Corazzari M, Melino G, Costanzo A, Levrero M and Knight RA (1999) Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants e and z. Cell Death Differ. 6: 389-390.
23. Kovalev S, Marchenko N, Swendeman S, LaQuaglia M and Moll UM (1998) Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Diff. 9: 897-903.
24. Mai M, Yokomizo A, Qian C, Yang P, Tindall DJ, Smith DI and Liu W (1998) Activation of p73 silent allele in lung cancer. Cancer Res. 58: 2347-2349.
25. Sunahara M, Ichimiya S, Nuimura Y, Takada N, Sakiyama S, Sato Y, Todo S, Adachi W, Amano J and Nakagawara A (1998) Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. Int. J. Oncol. 13: 319-323.
26. Zaika Al, Kovalev S, Marchenko D and Moll UM (1999) Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res. 59: 3257-3263.
27. Yokomizo A, Mai M, Tindall DJ, Cheng L, Bostwick D, Naito S, Smith DI and Liu W (1999) Overexpression of the wild type p73 gene in human bladder cancer. Oncogene 18: 1629-1633.
28. Tannapfel A, Engeland K, Weinans L, Katalinic A, Hauss J, Mossner J and Wittekind CH (1999) Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver. Br. J. Cancer 80: 1069-1074.
29. Caron H, van Sluis P, van Hoeve M, de Kraker J, Bras J, Slater R, Mannens M, Voute PA, Westerveld A and Versteeg R (1993) Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification. Nat. Genet. 4: 187-190.
30. Caron H, Peter M, van Sluis P, Speleman F, de Kraker J, Laureys G, Michon J, Brugieres L, Voute PA, Westerveld A, Slater R, Delattre O and Versteeg R (1995) Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. Hum. Mol. Genet. 4: 535-539.
31. Mai M, Huang H, Reed C, Qian C, smith JS, Alderete B, Jenkins R, Smith DI and Liu W (1998) Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-Arm deletion. Genomics 51: 359-363.
32. Mai M, Qian C, Yokomizo A, Tindall DJ, Bostwick D, Polychronakos C, Smith DI and Liu W (1998) Loss of imprinting and allele switching of p73 in renal cell carcinoma. Oncogene 17: 1739-1741.
33. Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68: 820-823.
34. Takada N, Ozaki T, Ichimiya S, Todo S and Nakagawara A (1999) Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas. Cancer Res. 59: 2810-2814.
35. Han S, Semba S, Abe T, Makino N, Furukawa T, Fukushige S, Takahashi H, Sakurada A, Sato M, Shiiba K, Matsuno S, Nimura Y, Nakagawara A and Horii A (1999) Infrequent somatic mutations of the p73 gene in various human cancers. Eur. J. Surg. Oncol. 25: 194-198.
36. Sunahara M, Shishikura T, Takahashi M, Todo S, Yamamoto N, Kimura H, Kato S, Ishioka C, Ikawa S, Ikawa Y and Nakagawara A (1999) Mutational analysis of p51A/TAp63;; a p53 homolog, in non-small cell lung cancer and breast cancer. Oncogene 18: 3761-3765.
37. Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M and Ikawa S (1999) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4: 839-843.
38. Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG Jr, Levrero M and Wang JY (1999) The tyrosine kinase c-Ab1 regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809.
39. Di Como CJ, Gaiddon C and Prives C (1999) p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol. Cell. Biol. 19: 1438-1449.
40. Chi SW, Ayed A and Arrowsmith CH (1999) Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO J. 18: 4438-4445.
41. Yokomizo A, Mai M, Bostwick DG, Tindall DJ, Qian J, Cheng L, Jenkins RB, Smith DI and Liu W (1999) Mutation and expression analysis of the p73 gene in prostate cancer. The Prostate 39: 94-100.
42. Kroiss MM, Bosserhoff A-K, Vogt T, Buettner R, Bogenrieder T, Landthaler M and Stolz W (1998) Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant malanomas. Melanoma Res. 8: 504-509.
43. Mihara M, Nimura Y, Ichimiya S, Sakiyama S, Kajikawa S, Adachi W, Amano J and Nakagawara A (1999) Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma. Br. J. Cancer 79: 164-167.
44. Shishikura T, Ichimiya S, Ozaki T, Nimura Y, Kageyama H, Nakamura Y, Sakiyama S, Miyauchi M, Yamamoto N, Suzuki M, Nakajima N and Nakagawara A (1999) Mutational analysis of the p73 gene in human breast cancers. Int. J. Cancer 84: 321-325.
45. Loiseau H, Arsaut J and Demotes-Mainard J (1999) p73 gene transcripts in human brain tumors: overexpression and altered splicing in ependymomas.
46. Yoshikawa H, Nagashima M, Khan MA, McMenamin MG, Hagiwara Kand Harris CC (1999) Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene 18: 3415-3421.
47. Tsao H, Zhang X, Majewski P and Haluska FG (1999) Mutational and expression analysis of the p73 gene in melanoma cell lines. Cancer Res. 59: 172-174.
48. Ozaki T, Naka M, Takada N, Tada M, Sakiyama S and Nakagawara A (1999) Deletion of the COOH-terminal region of p73a enchances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells. Cancer Res. in press.