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Volumn 4, Issue 4, 2003, Pages 233-247

Exploiting the p53 pathway for cancer diagnosis and therapy

Author keywords

Cancer; Mdm2; p14Arf; p53; Tumour therapy

Indexed keywords

4 (3 DIMETHYLAMINOPROPYLAMINO) 2 (4 METHOXYSTYRYL)QUINAZOLINE; 6 CYCLOHEXYLMETHOXY 2 (4 SULFAMOYLANILINO)PURINE; 6 O CYCLOHEXYLMETHYLGUANINE; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; ARF PROTEIN; CISPLATIN; COMPLEMENTARY RNA; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYCLOPHOSPHAMIDE; EPIRUBICIN; FLAVAPIRIDOL; FLUOROURACIL; MITOGEN ACTIVATED PROTEIN KINASE; OLOMOUCIN; ONYX 015; ONYX 411; PACLITAXEL; PIFITHRIN ALPHA; PRIMA 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MDM2; PROTEIN P53; ROSCOVITINE; ROSCOVOTINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0043025622     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200260     Document Type: Review
Times cited : (25)

References (107)
  • 1
    • 0037398860 scopus 로고    scopus 로고
    • Protecting p53 from degradation
    • Lain S. Protecting p53 from degradation. Biochem Soc Trans 2003; 31: 482-485.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 482-485
    • Lain, S.1
  • 2
    • 0034668786 scopus 로고    scopus 로고
    • Strategies for manipulating the p53 pathway in the treatment of human cancer
    • Ted RH, David PL, Kathryn LB. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem J 2000; 352: 1-17.
    • (2000) Biochem. J. , vol.352 , pp. 1-17
    • Ted, R.H.1    David, P.L.2    Kathryn, L.B.3
  • 3
    • 0030265337 scopus 로고    scopus 로고
    • The p53-deficient mouse: A model for basic and applied cancer studies
    • Donehower LA. The p53-deficient mouse: a model for basic and applied cancer studies. Semin Cancer Biol 1996; 7: 269-278.
    • (1996) Semin. Cancer Biol. , vol.7 , pp. 269-278
    • Donehower, L.A.1
  • 4
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava S, Zou ZQ, Pirollo K, Blattner W, Chang EH. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 1990; 348: 747-749.
    • (1990) Nature , vol.348 , pp. 747-749
    • Srivastava, S.1    Zou, Z.Q.2    Pirollo, K.3    Blattner, W.4    Chang, E.H.5
  • 6
    • 0037067656 scopus 로고    scopus 로고
    • p53: Good cop/bad cop
    • Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell 2002; 110: 9-12.
    • (2002) Cell , vol.110 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 7
    • 0034656243 scopus 로고    scopus 로고
    • Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
    • Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 2000; 14: 981-993.
    • (2000) Genes Dev. , vol.14 , pp. 981-993
    • Zhao, R.1    Gish, K.2    Murphy, M.3    Yin, Y.4    Notterman, D.5    Hoffman, W.H.6
  • 8
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 9
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca LR, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378: 203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes de Oca, L.R.1    Wagner, D.S.2    Lozano, G.3
  • 10
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387: 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 11
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 12
    • 12444338139 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Catherine JT, James AG, Robert T. Repression of p53-mediated transcription by MDM2: a dual mechanism. Gen Dev 1997; 272: 21403-21407.
    • (1997) Gen. Dev. , vol.272 , pp. 21403-21407
    • Catherine, J.T.1    James, A.G.2    Robert, T.3
  • 13
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2: 594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 14
    • 0036157247 scopus 로고    scopus 로고
    • Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
    • Lu ML, Wikman F, ORntoft TF, Charytonowicz E, Rabbani F, Zhang Z et al. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin Cancer Res 2002; 8: 171-179.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 171-179
    • Lu, M.L.1    Wikman, F.2    ORntoft, T.F.3    Charytonowicz, E.4    Rabbani, F.5    Zhang, Z.6
  • 15
  • 17
    • 0033992478 scopus 로고    scopus 로고
    • p53 and human cancer: The first ten thousand mutations
    • Hainaut P, Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 2000; 77: 81-137.
    • (2000) Adv. Cancer Res. , vol.77 , pp. 81-137
    • Hainaut, P.1    Hollstein, M.2
  • 18
    • 0030825813 scopus 로고    scopus 로고
    • p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley CA, Lane DP. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 1997; 15: 1179-1189.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 20
    • 0034671945 scopus 로고    scopus 로고
    • Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
    • Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res 2000; 60: 6788-6793.
    • (2000) Cancer Res. , vol.60 , pp. 6788-6793
    • Sigal, A.1    Rotter, V.2
  • 22
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • Foster BA, Coffey HA, Morin MJ, Rastinejad F. Pharmacological rescue of mutant p53 conformation and function. Science 1999; 286: 2507-2510.
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 25
    • 0036128899 scopus 로고    scopus 로고
    • Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
    • Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 2002; 8: 282-288.
    • (2002) Nat. Med. , vol.8 , pp. 282-288
    • Bykov, V.J.1    Issaeva, N.2    Shilov, A.3    Hultcrantz, M.4    Pugacheva, E.5    Chumakov, P.6
  • 26
    • 18644384688 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
    • Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 2002; 419: 849-853.
    • (2002) Nature , vol.419 , pp. 849-853
    • Zheng, H.1    You, H.2    Zhou, X.Z.3    Murray, S.A.4    Uchida, T.5    Wulf, G.6
  • 27
    • 18644384283 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
    • Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 2002; 419: 853-857.
    • (2002) Nature , vol.419 , pp. 853-857
    • Zacchi, P.1    Gostissa, M.2    Uchida, T.3    Salvagno, C.4    Avolio, F.5    Volinia, S.6
  • 28
    • 0037062920 scopus 로고    scopus 로고
    • Emerging clinical applications of RNA
    • Sullenger BA, Gilboa E. Emerging clinical applications of RNA. Nature 2002; 418: 252-258.
    • (2002) Nature , vol.418 , pp. 252-258
    • Sullenger, B.A.1    Gilboa, E.2
  • 29
    • 0034682505 scopus 로고    scopus 로고
    • Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
    • Watanabe T, Sullenger BA. Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. Proc Natl Acad Sci USA 2000; 97: 8490-8494.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8490-8494
    • Watanabe, T.1    Sullenger, B.A.2
  • 30
    • 0025611503 scopus 로고
    • Genetic mechanisms of tumor suppression by the human p53 gene
    • Chen PL, Chen YM, Bookstein R, Lee WH. Genetic mechanisms of tumor suppression by the human p53 gene. Science 1990; 250: 1576-1580.
    • (1990) Science , vol.250 , pp. 1576-1580
    • Chen, P.L.1    Chen, Y.M.2    Bookstein, R.3    Lee, W.H.4
  • 31
    • 0035164924 scopus 로고    scopus 로고
    • Clinical evaluation of adenoviral-mediated p53 gene transfer: Review of INGN 201 studies
    • Merritt JA, Roth JA, Logothetis CJ. Clinical evaluation of adenoviral-mediated p53 gene transfer: review of INGN 201 studies. Semin Oncol 2001; 28: 105-114.
    • (2001) Semin. Oncol. , vol.28 , pp. 105-114
    • Merritt, J.A.1    Roth, J.A.2    Logothetis, C.J.3
  • 32
    • 0035816146 scopus 로고    scopus 로고
    • Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy
    • Xu L, Pirollo KF, Chang EH. Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy. J Control Release 2001; 74: 115-128.
    • (2001) J. Control Release , vol.74 , pp. 115-128
    • Xu, L.1    Pirollo, K.F.2    Chang, E.H.3
  • 33
    • 0030969022 scopus 로고    scopus 로고
    • p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy
    • Pirollo KF, Hao Z, Rait A, Jang YJ, Fee Jr WE, Ryan P et al. p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy. Oncogene 1997; 14: 1735-1746.
    • (1997) Oncogene , vol.14 , pp. 1735-1746
    • Pirollo, K.F.1    Hao, Z.2    Rait, A.3    Jang, Y.J.4    Fee W.E., Jr.5    Ryan, P.6
  • 35
    • 0031953510 scopus 로고    scopus 로고
    • Intercellular delivery of functional p53 by the herpesvirus protein VP22
    • Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 1998; 16: 440-443.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 440-443
    • Phelan, A.1    Elliott, G.2    O'Hare, P.3
  • 36
    • 0036267436 scopus 로고    scopus 로고
    • VP22-mediated intercellular transport of p53 in hepatoma cells in vitro and in vivo
    • Zender L, Kuhnel F, Kock R, Manns M, Kubicka S. VP22-mediated intercellular transport of p53 in hepatoma cells in vitro and in vivo. Cancer Gene Ther 2002; 9: 489-496.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 489-496
    • Zender, L.1    Kuhnel, F.2    Kock, R.3    Manns, M.4    Kubicka, S.5
  • 37
    • 0036320613 scopus 로고    scopus 로고
    • Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors
    • Zender L, Kock R, Eckhard M, Frericks B, Gosling T, Gebhardt T et al. Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors. Gastroenterology 2002; 123: 608-618.
    • (2002) Gastroenterology , vol.123 , pp. 608-618
    • Zender, L.1    Kock, R.2    Eckhard, M.3    Frericks, B.4    Gosling, T.5    Gebhardt, T.6
  • 39
    • 0036726577 scopus 로고    scopus 로고
    • Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy
    • Nicklin SA, Baker AH. Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy. Curr Gene Ther 2002; 2: 273-293.
    • (2002) Curr. Gene Ther. , vol.2 , pp. 273-293
    • Nicklin, S.A.1    Baker, A.H.2
  • 40
    • 0034997403 scopus 로고    scopus 로고
    • Non-viral vectors in cancer gene therapy: Principles and progress
    • Schatzlein AG. Non-viral vectors in cancer gene therapy: principles and progress. Anticancer Drugs 2001; 12: 275-304.
    • (2001) Anticancer Drugs , vol.12 , pp. 275-304
    • Schatzlein, A.G.1
  • 41
    • 0033544904 scopus 로고    scopus 로고
    • Transferrin-liposome-mediated systemic p53 gene therapy in combination with radiation results in regression of human head and neck cancer xenografts
    • Xu L, Pirollo KF, Tang WH, Rait A, Chang E H. Transferrin-liposome-mediated systemic p53 gene therapy in combination with radiation results in regression of human head and neck cancer xenografts. Hum Gene Ther 1999; 10: 2941-2952.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2941-2952
    • Xu, L.1    Pirollo, K.F.2    Tang, W.H.3    Rait, A.4    Chang, E.H.5
  • 42
    • 0036207583 scopus 로고    scopus 로고
    • Self-assembly of a virus-mimicking nanostructure system for efficient tumor-targeted gene delivery
    • Xu L, Frederik P, Pirollo KF, Tang WH, Rait A, Xiang LM et al. Self-assembly of a virus-mimicking nanostructure system for efficient tumor-targeted gene delivery. Hum Gene Ther 2002; 13: 469-481.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 469-481
    • Xu, L.1    Frederik, P.2    Pirollo, K.F.3    Tang, W.H.4    Rait, A.5    Xiang, L.M.6
  • 43
    • 0035174928 scopus 로고    scopus 로고
    • Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv
    • Xu L, Tang WH, Huang CC, Alexander W, Xiang LM, Pirollo KF et al. Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv. Mol Med 2001; 7: 723-734.
    • (2001) Mol. Med. , vol.7 , pp. 723-734
    • Xu, L.1    Tang, W.H.2    Huang, C.C.3    Alexander, W.4    Xiang, L.M.5    Pirollo, K.F.6
  • 45
    • 0037058678 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
    • McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int J Cancer 2002; 102: 463-468.
    • (2002) Int. J. Cancer , vol.102 , pp. 463-468
    • McClue, S.J.1    Blake, D.2    Clarke, R.3    Cowan, A.4    Cummings, L.5    Fischer, P.M.6
  • 46
    • 0034812298 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382
    • Ljungman M, Paulsen MT. The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol Pharmacol 2001; 60: 785-789.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 785-789
    • Ljungman, M.1    Paulsen, M.T.2
  • 47
    • 0034721195 scopus 로고    scopus 로고
    • Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
    • Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF et al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem 2000; 43: 2797-2804.
    • (2000) J. Med. Chem. , vol.43 , pp. 2797-2804
    • Arris, C.E.1    Boyle, F.T.2    Calvert, A.H.3    Curtin, N.J.4    Endicott, J.A.5    Garman, E.F.6
  • 49
    • 0036830109 scopus 로고    scopus 로고
    • Highly potent p21WAF1-derived peptide inhibitors of CDK-mediated pRb phosphorylation: Delineation and structural insight into their interactions with cyclin A
    • Zheleva DI, McInnes C, Gavine AL, Zhelev NZ, Fischer PM, Lane DP. Highly potent p21WAF1-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A. J Peptide Res 2002; 60: 257-270.
    • (2002) J. Peptide Res. , vol.60 , pp. 257-270
    • Zheleva, D.I.1    McInnes, C.2    Gavine, A.L.3    Zhelev, N.Z.4    Fischer, P.M.5    Lane, D.P.6
  • 50
    • 0035843123 scopus 로고    scopus 로고
    • Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
    • Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001; 20: 147-155.
    • (2001) Oncogene , vol.20 , pp. 147-155
    • Bacus, S.S.1    Gudkov, A.V.2    Lowe, M.3    Lyass, L.4    Yung, Y.5    Komarov, A.P.6
  • 51
    • 0037077831 scopus 로고    scopus 로고
    • Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy
    • Bertheau P, Plassa F, Espie M, Turpin E, De Roquancourt A, Marty M et al. Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet 2002; 360: 852-854.
    • (2002) Lancet , vol.360 , pp. 852-854
    • Bertheau, P.1    Plassa, F.2    Espie, M.3    Turpin, E.4    De Roquancourt, A.5    Marty, M.6
  • 52
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • Green DR, Evan GI. A matter of life and death. Cancer Cell 2002; 1: 19-30.
    • (2002) Cancer Cell , vol.1 , pp. 19-30
    • Green, D.R.1    Evan, G.I.2
  • 53
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 10: 57-70.
    • (2000) Cell , vol.10 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 54
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002; 108: 153-164.
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 55
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • Seoane J, Le HV, Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002; 419: 729-734.
    • (2002) Nature , vol.419 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massague, J.3
  • 56
    • 0036716281 scopus 로고    scopus 로고
    • The bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM. The bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2: 647-656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 57
    • 0037157850 scopus 로고    scopus 로고
    • Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
    • Bourdon JC, Renzing J, Robertson PL, Fernandes KN, Lane DP. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J Cell Biol 2002; 158: 235-246.
    • (2002) J. Cell Biol. , vol.158 , pp. 235-246
    • Bourdon, J.C.1    Renzing, J.2    Robertson, P.L.3    Fernandes, K.N.4    Lane, D.P.5
  • 58
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 59
    • 0034640281 scopus 로고    scopus 로고
    • Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288: 1053-1058.
    • (2000) Science , vol.288 , pp. 1053-1058
    • Oda, E.1    Ohki, R.2    Murasawa, H.3    Nemoto, J.4    Shibue, T.5    Yamashita, T.6
  • 60
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic, gene is induced by p53
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic, gene is induced by p53. Mol Cell 2001; 7: 683-694.
    • (2001) Mol. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 61
    • 0030938089 scopus 로고    scopus 로고
    • Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 1997; 94: 2345-2349.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2345-2349
    • McCurrach, M.E.1    Connor, T.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 62
    • 0030614915 scopus 로고    scopus 로고
    • Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
    • Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M et al. Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 1997; 275: 983-986.
    • (1997) Science , vol.275 , pp. 983-986
    • Sattler, M.1    Liang, H.2    Nettesheim, D.3    Meadows, R.P.4    Harlan, J.E.5    Eberstadt, M.6
  • 63
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    • Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000; 97: 7124-7129.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7124-7129
    • Wang, J.L.1    Liu, D.2    Zhang, Z.J.3    Shan, S.4    Han, X.5    Srinivasula, S.M.6
  • 64
    • 0035150803 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
    • Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol 2001; 3: 173-182.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 173-182
    • Degterev, A.1    Lugovskoy, A.2    Cardone, M.3    Mulley, B.4    Wagner, G.5    Mitchison, T.6
  • 66
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A, Bassik M, Walensky L, Sorcinelli M, Weiler S, Korsmeyer S. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002; 2: 183-192.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.2    Walensky, L.3    Sorcinelli, M.4    Weiler, S.5    Korsmeyer, S.6
  • 67
    • 0036710477 scopus 로고    scopus 로고
    • Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
    • Baell J, Huang D. Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem Pharmacol 2002; 64: 851-863.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 851-863
    • Baell, J.1    Huang, D.2
  • 69
    • 0036654694 scopus 로고    scopus 로고
    • A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
    • Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2002; 2: 29-42.
    • (2002) Cancer Cell , vol.2 , pp. 29-42
    • Fantin, V.R.1    Berardi, M.J.2    Scorrano, L.3    Korsmeyer, S.J.4    Leder, P.5
  • 70
    • 0033980572 scopus 로고    scopus 로고
    • Targeting gene expression to tumor cells with loss of wild-type p53 function
    • Zhu J, Gao B, Zhao J, Balmain A. Targeting gene expression to tumor cells with loss of wild-type p53 function. Cancer Gene Ther 2000; 7: 4-12.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 4-12
    • Zhu, J.1    Gao, B.2    Zhao, J.3    Balmain, A.4
  • 71
    • 0035956213 scopus 로고    scopus 로고
    • Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus
    • White E. Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus. Oncogene 2001; 20: 7836-7846.
    • (2001) Oncogene , vol.20 , pp. 7836-7846
    • White, E.1
  • 72
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274: 373-376.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3    Heise, C.4    Horn, S.5    Muna, M.6
  • 73
    • 0031697581 scopus 로고    scopus 로고
    • Killing tumor cells with viruses-a question of specificity
    • Lane DP. Killing tumor cells with viruses-a question of specificity. Nat Med 1998; 4: 1012-1013.
    • (1998) Nat. Med. , vol.4 , pp. 1012-1013
    • Lane, D.P.1
  • 74
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • Khuri FR, Nemunaitis J, Ganly I, Arseneau J, Tannock IF, Romel L et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 2000; 6: 879-885.
    • (2000) Nat. Med. , vol.6 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3    Arseneau, J.4    Tannock, I.F.5    Romel, L.6
  • 75
    • 0034759057 scopus 로고    scopus 로고
    • Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy
    • Ramachandra M, Rahman A, Zou A, Vaillancourt M, Howe JA, Antelman D et al. Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy. Nat Biotechnol 2001; 19: 1035-1041.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 1035-1041
    • Ramachandra, M.1    Rahman, A.2    Zou, A.3    Vaillancourt, M.4    Howe, J.A.5    Antelman, D.6
  • 76
    • 19044386714 scopus 로고    scopus 로고
    • Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
    • Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M et al. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell 2002; 1: 325-337.
    • (2002) Cancer Cell , vol.1 , pp. 325-337
    • Johnson, L.1    Shen, A.2    Boyle, L.3    Kunich, J.4    Pandey, K.5    Lemmon, M.6
  • 78
    • 0033552585 scopus 로고    scopus 로고
    • The role of the E6-p53 interaction in the molecular pathogenesis of HPV
    • Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene 1999; 18: 7690-7700.
    • (1999) Oncogene , vol.18 , pp. 7690-7700
    • Thomas, M.1    Pim, D.2    Banks, L.3
  • 79
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr C, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002; 2: 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.1    McCormick, F.2
  • 81
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. RNA interference. Nature 2002; 418: 244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 82
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002; 21: 6041-6048.
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 83
    • 0034177304 scopus 로고    scopus 로고
    • How to activate p53
    • Caspari T. How to activate p53. Curr Biol 2000; 10: R315-R317.
    • (2000) Curr. Biol. , vol.10
    • Caspari, T.1
  • 84
    • 0037103190 scopus 로고    scopus 로고
    • ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma
    • Gronbaek K, Worm J, Ralfkiaer E, Ahrenkiel V, Hokland P, Guldberg P. ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma. Blood 2002; 100: 1430-1437.
    • (2002) Blood , vol.100 , pp. 1430-1437
    • Gronbaek, K.1    Worm, J.2    Ralfkiaer, E.3    Ahrenkiel, V.4    Hokland, P.5    Guldberg, P.6
  • 85
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002; 21: 5195-5205.
    • (2002) EMBO J. , vol.21 , pp. 5195-5205
    • Takai, H.1    Naka, K.2    Okada, Y.3    Watanabe, M.4    Harada, N.5    Saito, S.6
  • 88
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
    • Wang H, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin Cancer Res 2001; 7: 3613-3624.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3613-3624
    • Wang, H.1    Nan, L.2    Yu, D.3    Agrawal, S.4    Zhang, R.5
  • 89
    • 0036042573 scopus 로고    scopus 로고
    • Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms
    • Wang H, Nan L, Yu D, Lindsey JR, Agrawal S, Zhang R. Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms. Mol Med 2002; 8: 185-199.
    • (2002) Mol. Med. , vol.8 , pp. 185-199
    • Wang, H.1    Nan, L.2    Yu, D.3    Lindsey, J.R.4    Agrawal, S.5    Zhang, R.6
  • 90
    • 0033210893 scopus 로고    scopus 로고
    • MDM2 oncogene as a target for cancer therapy: An antisense approach
    • Wang H, Zeng X, Oliver P, Le LP, Chen J, Chen L et al. MDM2 oncogene as a target for cancer therapy: An antisense approach. Int J Oncol 1999; 15: 653-660.
    • (1999) Int. J. Oncol. , vol.15 , pp. 653-660
    • Wang, H.1    Zeng, X.2    Oliver, P.3    Le, L.P.4    Chen, J.5    Chen, L.6
  • 91
    • 0034973788 scopus 로고    scopus 로고
    • Activation of p53 by roscovitine-mediated suppression of MDM2 expression
    • Lu W, Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20: 3206-3216.
    • (2001) Oncogene , vol.20 , pp. 3206-3216
    • Lu, W.1    Chen, L.2    Peng, Y.3    Chen, J.4
  • 92
    • 0030965298 scopus 로고    scopus 로고
    • Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2
    • Blaydes JP, Gire V, Rowson JM, Wynford-Thomas D. Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2. Oncogene 1997; 14: 1859-1868.
    • (1997) Oncogene , vol.14 , pp. 1859-1868
    • Blaydes, J.P.1    Gire, V.2    Rowson, J.M.3    Wynford-Thomas, D.4
  • 93
    • 0032566066 scopus 로고    scopus 로고
    • The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2
    • Blaydes JP, Wynford-Thomas D. The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2. Oncogene 1998; 16: 3317-3322.
    • (1998) Oncogene , vol.16 , pp. 3317-3322
    • Blaydes, J.P.1    Wynford-Thomas, D.2
  • 95
    • 0031282325 scopus 로고    scopus 로고
    • Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
    • Bottger A, Bottger V, Sparks A, Liu WL, Howard SF, Lane DP. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr Biol 1997; 7: 860-869.
    • (1997) Curr. Biol. , vol.7 , pp. 860-869
    • Bottger, A.1    Bottger, V.2    Sparks, A.3    Liu, W.L.4    Howard, S.F.5    Lane, D.P.6
  • 96
    • 0037317840 scopus 로고    scopus 로고
    • Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
    • Chene P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat Rev Cancer 2003; 3: 102-109.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 102-109
    • Chene, P.1
  • 97
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001; 2: 731-737.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 98
    • 18444380541 scopus 로고    scopus 로고
    • INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
    • Brookes S, Rowe J, Ruas M, Llanos S, Clark PA, Lomax M et al. INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J 2002; 21: 2936-2945.
    • (2002) EMBO J. , vol.21 , pp. 2936-2945
    • Brookes, S.1    Rowe, J.2    Ruas, M.3    Llanos, S.4    Clark, P.A.5    Lomax, M.6
  • 100
    • 0035899468 scopus 로고    scopus 로고
    • Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
    • Xirodimas D, Saville MK, Edling C, Lane DP, Lain S. Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 2001; 20: 4972-4983.
    • (2001) Oncogene , vol.20 , pp. 4972-4983
    • Xirodimas, D.1    Saville, M.K.2    Edling, C.3    Lane, D.P.4    Lain, S.5
  • 101
    • 0035887286 scopus 로고    scopus 로고
    • Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53
    • Xirodimas, DP, Stephen, CW, Lane DP. Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53. Exp Cell Res 2001; 270: 66-77.
    • (2001) Exp. Cell Res. , vol.270 , pp. 66-77
    • Xirodimas, D.P.1    Stephen, C.W.2    Lane, D.P.3
  • 102
    • 0034603897 scopus 로고    scopus 로고
    • An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
    • Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT et al. An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene 2000; 19: 2312-2323.
    • (2000) Oncogene , vol.19 , pp. 2312-2323
    • Midgley, C.A.1    Desterro, J.M.2    Saville, M.K.3    Howard, S.4    Sparks, A.5    Hay, R.T.6
  • 103
    • 0036385406 scopus 로고    scopus 로고
    • Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin
    • Deng X, Kim M, Vandier D, Jung Y, Rikiyama T, Sgagias M et al. Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin. Biochem Biophys Res Commun 2002; 296: 792-798.
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 792-798
    • Deng, X.1    Kim, M.2    Vandier, D.3    Jung, Y.4    Rikiyama, T.5    Sgagias, M.6
  • 104
    • 0036025370 scopus 로고    scopus 로고
    • Adenovirus-Mediated p14ARF Gene Transfer Cooperates with Ad5CMV-p53 to Induce Apoptosis in Human Cancer Cells
    • Tango Y, Fujiwara T, Itoshima T, Takata Y, Katsuda K, Uno F et al. Adenovirus-Mediated p14ARF Gene Transfer Cooperates with Ad5CMV-p53 to Induce Apoptosis in Human Cancer Cells. Hum Gene Ther 2002; 13: 1373-1382.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 1373-1382
    • Tango, Y.1    Fujiwara, T.2    Itoshima, T.3    Takata, Y.4    Katsuda, K.5    Uno, F.6
  • 105
    • 18744406282 scopus 로고    scopus 로고
    • Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
    • Lai Z, Yang T, Kim YB, Sielecki TM, Diamond MA, Strack P et al. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc Natl Acad Sci USA 2002; 99: 14734-14739.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14734-14739
    • Lai, Z.1    Yang, T.2    Kim, Y.B.3    Sielecki, T.M.4    Diamond, M.A.5    Strack, P.6
  • 106
    • 0036463948 scopus 로고    scopus 로고
    • Perspectives on the development of a molecularly targeted agent
    • Druker BJ. Perspectives on the development of a molecularly targeted agent. Cancer Cell 2002; 1: 31-36.
    • (2002) Cancer Cell , vol.1 , pp. 31-36
    • Druker, B.J.1
  • 107
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2002; 2: 331-341.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2


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