Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 5, 2002, Pages 2948-2953

  De Vries, Annemieke ^a,b   Flores, Elsa R ^a   Miranda, Barbara ^a   Hsieh, Harn Mei ^a   Van Oostrom, Conny Th M ^b   Sage, Julien ^a   Jacks, Tyler ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLASTOCYTE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; GAMMA IRRADIATION; MISSENSE MUTATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; THYMOCYTE; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLASTOCYST; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; FEMALE; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; HUMANS; HYBRID CELLS; LYMPHOID TISSUE; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; POINT MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STEM CELLS; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0037022606     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.052713099     Document Type: Article

References (25)