An N-terminal p14(ARF) peptide blocks Mdm2-dependent ubiquinitation in vitro and can activate p53 in vivo

Oncogene

Volumn 19, Issue 19, 2000, Pages 2312-2323

  Midgley, Carol A ^a   Desterro, Joana M P ^b   Saville, Mark K ^a   Howard, Stephanie ^a   Sparks, Alison ^a   Hay, Ronald T ^b   Lane, David P ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Mdm2; p14(ARF); p53 tumour suppressor; Protein stability; Transcriptional activation; Ubiquitination

Indexed keywords

GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NUCLEAR PROTEIN; PROTEIN MDM2; PROTEIN P14ARF; PROTEIN P53; RECOMBINANT PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; LIGASE; MDM2 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; ONCOPROTEIN; PEPTIDE FRAGMENT; PHOTOPROTEIN; PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MICROINJECTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING;

ANIMALIA;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; BINDING SITES; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HUMANS; LIGASES; LUMINESCENT PROTEINS; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 0034603897     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203593     Document Type: Article

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