Transferrin-liposome-mediated systemic p53 gene therapy in combination with radiation results in regression of human head and neck cancer xenografts

Human Gene Therapy

Volumn 10, Issue 18, 1999, Pages 2941-2952

  Xu, Liang ^a   Pirollo, Kathleen F ^a   Tang, Wen Hua ^a   Rait, Antonina ^a   Chang, Esther H ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TRANSFERRIN;

ARTICLE; CANCER RADIOTHERAPY; GENE THERAPY; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; SQUAMOUS CELL CARCINOMA; TARGET CELL DESTRUCTION; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; GENE THERAPY; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS; LIPOSOMES; MICE; NEOPLASM TRANSPLANTATION; TRANSFERRIN;

MUS MUSCULUS;

EID: 0033544904     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016357     Document Type: Article

References (40)

1. BATES, S., and VOUSDEN, K.H. (1999). Mechanisms of p53-mediated apoptosis. Cell. Mol. Life Sci. 55, 28-37.
2. BRISTOW, R.G., BENCHIMOL, S., and HILL, R.P. (1996). The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother. Oncol. 40, 197-223.
3. CHACKAL-ROY, M., NIEMEYER, C., MOORE, M., and ZETTER, B.R. (1989). Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow. J. Clin. Invest. 84, 43-50.
4. CHANG, E.H., JANG, Y.J., HAO, Z., MURPHY, G., RAIT, A., FEE, W.E., Jr., SUSSMAN, H.H., RYAN, P., CHIANG, Y., and PIROLLO, K.F. (1997). Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitizes squamous cell carcinoma of the head and neck to radiotherapy. Arch. Otolaryngol. Head Neck Surg. 123, 507-512.
5. CHENG, P.W. (1996). Receptor ligand-facilitated gene transfer: Enhancement of liposome-mediated gene transfer and expression by transferrin. Hum. Gene Ther. 7, 275-282.
6. CHRISTIANO, R.J., and CURIEL, D.T. (1996). Strategies to accomplish gene therapy via the receptor-mediated endocytosis pathways. Cancer Gene Ther. 3, 457-497.
7. CLAYMAN, G.L., EL-NAGGAR, A.K., ROTH, J.A., ZHANG, W.W., GOEPFERT, H., TAYLOR, D.L., and LIU, T.J. (1995). In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res. 55, 1-6.
8. DIMERY, I.W., and HONG, W.K. (1993). Overview of combined modality therapies for head and neck cancer. J. Natl. Cancer Inst. 85, 95-111.
9. ELLIOTT, R.L., ELLIOTT, M.C., WANG, F., and HEAD, J.F. (1993). Breast carcinoma and the role of iron metabolism. A cytochemical. tissue culture, and ultrastructural study. Ann. N.Y. Acad. Sci. 698, 159-166.
10. FELGNER, P.L., TSAI, Y.J., SUKHU, L., WHEELER, C.J., MANTHORPE, M., and MARSHALL, J. (1995). Improved cationic lipid formulations for in vivo gene therapy. Ann. N.Y. Acad. Sci. 772, 126-139.
11. FUJIWARA, T., GRIMM, E.A., MUKHOPADHYAY, T., ZHANG, W.W., OWEN-SCHAUB, L.B., and ROTH, J.A. (1994). Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res. 54, 2287-2291.
12. GRAYHACK, J.T., WENDEL, E.F., OLIVER, L., and LEE, C. (1979). Analysis of specific proteins in prostatic fluid for detecting prostatic malignancy. J. Urol. 121, 295-299.
13. HALL, S.J., SANFORD, M.A., ATKINSON, G., and CHEN, S.H. (1998). Induction of potent antitumor natural killer cell activity by herpes simplex virus-thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer. Cancer Res. 58, 3221-3225.
14. HUANG, L., and VIROONCHATAPAN, E. (1990). Introduction. In Non-Virtil Vectors for Gene Therapy. L. Huang, M.C. Hung, and E. Wagner, eds. (Academic Press. San Diego, CA) pp. 3-22.
15. INOUE, T., CAVANAUGH, P.G., STECK, P.A., BRUNNER, N., and NICOLSON, G.L. (1993). Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials. J. Cell Physiol. 156, 212-217.
16. KEER, H.N., KOZLOWSKI, J.M., and TSAI, M.C. (1990). Elevated transferrin receptor content in human prostate cancer cell lines assessed in vitro and in vivo. J. Urol. 143, 381-385.
17. LANDIS, S.H., MURRAY, T., BOLDEN, S., and WINGO, P.A. (1998). Cancer statistics, 1998. CA Cancer J. Clin. 48, 6-29.
18. LEE, J.M., and BERNSTEIN, A. (1993). p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. U.S.A. 90, 5742-5746.
19. LESOON-WOOD, L.A., HO KIM, W., KLEINMAN, H.R., WEINTRAUB, B.D., and MIXSON, A.J. (1995). Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice. Hum. Gene Ther. 6, 395-405.
20. LIU, T.J., EL-NAGGAR, A.K., McDONNELL, T.J., STECK, K.D., WANG, M., and TAYLOR, D.L. (1995). Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 55, 3117-3122.
21. LIU, Y., THOR, A., SHTIVELMAN, E., CAO, Y., TU, G., HEATH, T.D., and DEBS, R.J. (1999). Systemic gene delivery expands the repertoire of effective antiangiogenic agents. J. Biol. Chem. 274, 13338-13344.
22. LOTZE, M.T., and JAFFE, R. (1999). Dendritic cells in disease: Cancer. In Dendritic Cells: Biology and Clinical Applications. M.T. Lotze and A.W. Thomson, eds. (Academic Press, San Diego, CA) pp. 325-338.
23. McILWRATH, A.J., VASEY, P.A., ROSS, G.M., and BROWN, R. (1994). Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res. 54, 3718-3722.
24. MENG, R.D., and EL-DEIRY, W.S. (1999). Tumor suppressor genes as targets for cancer gene therapy. In Gene Therapy of Cancer. E.C. Lattime and S.L. Gerson, eds. (Academic Press, San Diego, CA), pp. 3-20.
25. MIYAMOTO, T., TANAKA, N., EISHI, Y., and AMAGASA, T. (1994). Transferrin receptor in oral tumors. Int. J. Oral Maxillofac. Surg. (Denmark) 23, 430-433.
26. NIELSON, L.L., and MANEVAL, D.C. (1998). p53 tumor suppressor gene therapy for cancer. Cancer Gene Ther. 5, 52-63.
27. O'CONNOR, P.M., JACJMAN, J., JONDLE, D., BHATIA, K., MAGRATH, I., and KOHN, K.W. (1993). Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Res. 53, 4776-4780.
28. PERON, J.M., ESCHE, C., SUBBOTIN, V.M., MALISZEWSKI, C., LOTZE, M.T., and SHURIN, M.R. (1998). FLT3-ligand administration inhibits liver metastases: Role of NK cells. J. Immunol. 161, 6164-6170.
29. PIROLLO, K.F., HAO, Z., RAIT, A., JANG, Y.J., FEE, W.E., Jr., RYAN, P., CHIANG, Y., and CHANG, E.H. (1997). p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy. Oncogene 14, 1735-1746.
30. ROSSI, M.C., and ZETTER, B.R. (1992). Selective stimulation of prostatic carcinoma cell proliferation by transferrin. Proc. Natl. Acad. Sci. U.S.A. 89, 6197-6201.
31. ROTH, J.A. (1998). Restoration of tumour suppressor gene expression for cancer. Forum (Genova) 8, 368-376.
32. RULEY, H.E. (1996). p53 and response to chemotherapy and radiotherapy. In Important Advances in Oncology 1996. V.T. DeVita, S. Hellman, and S.A. Rosenberg, eds. (Lippincott-Raven, Philadelphia, PA), pp. 37-56.
33. TEMPLETON, N.S., LASIC, D.D., FREDERIK, P.M., STREY, H.H., ROBERTS, D.D., and PAVLAKIS, G.N. (1997). Improved DNA:liposome complexes for increased systemic delivery and gene expression. Nature Biotechnol. 15, 647-652.
34. THORSTENSEN, K., and ROMSLO, I. (1993). The transferrin receptor: Its diagnostic value and its potential as therapeutic target. Scand. J. Clin. Lab. Invest. Suppl. 215, 113-120.
35. VAN DONGEN, G.A., and SNOW, G.B. (1997). Prospects for future studies in head and neck cancer. Eur. J. Surg. Oncol. 23, 486-491.
36. [UNREF1WAGNER, E. (1999). Ligand-polycation conjugates for receptor-targeted gene transfer. In Non-Viral Vectors for Gene Therapy. L. Huang, M.C. Hung, and E. Wagner, eds. (Academic Press, San Diego, CA) pp. 208-227.
37. WEICHSELBAUM, R.R., BECKETT, M.A., VOKES, E.E., HALLAHAN, D.E., HARAF, D.J., and BRACHMAN, D.G. (1993). Cellular and molecular basis for radioresistance in head and neck cancer. Head Neck Cancer III, 399-407.
38. XU, L., PIROLLO, K.F., and CHANG, E.H. (1997). Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro. Hum. Gene Ther. 8, 467-475.
39. XU, L., PIROLLO, K.F., RAIT, A., MURRAY, A.L., and CHANG, E.H. (1990). Systemic p53 gene therapy in combination with radiation results in human tumor regression. Tumor Targeting 4, 92-104.
40. XU, M., KUMAR, D., SRINIVAS, S., DETOLLA, L.J., YU, S.F., STASS, S.A., and MIXSON, A.J. (1997). Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity. Hum. Gene Ther. 8, 177-185.