Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which app cleavage occurs without using toxic agents that interfere with protein metabolism

Journal of Biological Chemistry

Volumn 273, Issue 11, 1998, Pages 6277-6284

  Tomita, Susumu ^a   Kirino, Yutaka ^a   Suzuki, Toshiharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MUTANT PROTEIN; PROTEINASE; SECRETASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GOLGI COMPLEX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; SULFATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; ENDOPEPTIDASES; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; MUTATION; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

EID: 0032513060     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.11.6277     Document Type: Article

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