-
2
-
-
0028209548
-
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
-
Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 1994;263:1136-1139.
-
(1994)
Science
, vol.263
, pp. 1136-1139
-
-
Iwashima, M.1
Irving, B.A.2
Van Oers, N.S.3
Chan, A.C.4
Weiss, A.5
-
3
-
-
0029909498
-
The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization
-
Yamasaki S, Takamatsu M, Iwashima M. The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization. Mol Cell Biol 1996;16:7151-7160.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 7151-7160
-
-
Yamasaki, S.1
Takamatsu, M.2
Iwashima, M.3
-
4
-
-
0034687873
-
LAT the linker for activation of T cells: A bridge between T cell-specific and general signaling pathways
-
Wange RL. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci STKE 2000;2000:RE1.
-
(2000)
Sci STKE
, vol.2000
-
-
Wange, R.L.1
-
5
-
-
0033047309
-
Integration of T cell receptor-dependent signaling pathways by adapter proteins
-
Clements JL, Boerth NJ, Lee JR, Koretzky GA. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu Rev Immunol 1999;17:89-108.
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 89-108
-
-
Clements, J.L.1
Boerth, N.J.2
Lee, J.R.3
Koretzky, G.A.4
-
6
-
-
0035525572
-
Positive and negative regulation of T-cell activation by adaptor proteins
-
Koretzky GA, Myung PS. Positive and negative regulation of T-cell activation by adaptor proteins. Nat Rev Immunol 2001;1:95-107.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 95-107
-
-
Koretzky, G.A.1
Myung, P.S.2
-
7
-
-
0032101348
-
Membrane compartmentation is required for efficient T cell activation
-
Xavier R. Brennan T, Li Q, McCormack C, Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity 1998;8:723-732.
-
(1998)
Immunity
, vol.8
, pp. 723-732
-
-
Xavier, R.1
Brennan, T.2
Li, Q.3
McCormack, C.4
Seed, B.5
-
8
-
-
0032142953
-
LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
-
Zhang W, Trible RP, Samelson LE. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998;9:239-246.
-
(1998)
Immunity
, vol.9
, pp. 239-246
-
-
Zhang, W.1
Trible, R.P.2
Samelson, L.E.3
-
9
-
-
0031750335
-
Lipid domain structure of the plasma membrane revealed by patching of membrane components
-
Harder T, Scheiffele P, Verkade P, Simons K. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol 1998;141:929-942.
-
(1998)
J Cell Biol
, vol.141
, pp. 929-942
-
-
Harder, T.1
Scheiffele, P.2
Verkade, P.3
Simons, K.4
-
10
-
-
0032530369
-
Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
-
Montixi C, et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J 1998;17:5334-5348.
-
(1998)
EMBO J
, vol.17
, pp. 5334-5348
-
-
Montixi, C.1
-
11
-
-
0030949124
-
Functional rafts in cell membranes
-
Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387:569-572.
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
12
-
-
0032552054
-
GPI-anchored proteins are organized in submicron domains at the cell surface
-
Varma R, Mayor S. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 1998;394:798-801.
-
(1998)
Nature
, vol.394
, pp. 798-801
-
-
Varma, R.1
Mayor, S.2
-
13
-
-
0037012847
-
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
-
Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 2002;296:913-916.
-
(2002)
Science
, vol.296
, pp. 913-916
-
-
Zacharias, D.A.1
Violin, J.D.2
Newton, A.C.3
Tsien, R.Y.4
-
14
-
-
0032727709
-
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
-
Janes PW, Ley SC, Magee AI. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 1999;147:447-461.
-
(1999)
J Cell Biol
, vol.147
, pp. 447-461
-
-
Janes, P.W.1
Ley, S.C.2
Magee, A.I.3
-
15
-
-
0036604916
-
The T-cell receptor signalosome: A dynamic structure with expanding complexity
-
Werlen G, Palmer E. The T-cell receptor signalosome: a dynamic structure with expanding complexity. Curr Opin Immunol 2002;14:299-305.
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 299-305
-
-
Werlen, G.1
Palmer, E.2
-
16
-
-
0036794399
-
Staging and resetting T cell activation in SMACs
-
Freiberg BA, et al. Staging and resetting T cell activation in SMACs. Nat Immunol 2002;3:911-917.
-
(2002)
Nat Immunol
, vol.3
, pp. 911-917
-
-
Freiberg, B.A.1
-
17
-
-
0034232037
-
The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling
-
Dustin ML, Cooper JA. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol 2000;1:23-29.
-
(2000)
Nat Immunol
, vol.1
, pp. 23-29
-
-
Dustin, M.L.1
Cooper, J.A.2
-
18
-
-
0035901568
-
The immunological synapse: Required for T cell receptor signalling or directing T cell effector function?
-
Davis SJ, van der Merwe PA. The immunological synapse: required for T cell receptor signalling or directing T cell effector function? Curr Biol 2001;11:R289-R291.
-
(2001)
Curr Biol
, vol.11
-
-
Davis, S.J.1
Van Der Merwe, P.A.2
-
19
-
-
0032480279
-
Three-dimensional segregation of supramolecular activation clusters in T cells
-
Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
-
(1998)
Nature
, vol.395
, pp. 82-86
-
-
Monks, C.R.1
Freiberg, B.A.2
Kupfer, H.3
Sciaky, N.4
Kupfer, A.5
-
20
-
-
0033613826
-
T lymphocyte costimulation mediated by reorganization of membrane microdomains
-
Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999;283:680-682.
-
(1999)
Science
, vol.283
, pp. 680-682
-
-
Viola, A.1
Schroeder, S.2
Sakakibara, Y.3
Lanzavecchia, A.4
-
21
-
-
0035654908
-
Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells
-
Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 2001;15:729-738.
-
(2001)
Immunity
, vol.15
, pp. 729-738
-
-
Balamuth, F.1
Leitenberg, D.2
Unternaehrer, J.3
Mellman, I.4
Bottomly, K.5
-
22
-
-
0037154747
-
T cell receptor signaling precedes immunological synapse formation
-
Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS. T cell receptor signaling precedes immunological synapse formation. Science 2002;295:1539-1542.
-
(2002)
Science
, vol.295
, pp. 1539-1542
-
-
Lee, K.H.1
Holdorf, A.D.2
Dustin, M.L.3
Chan, A.C.4
Allen, P.M.5
Shaw, A.S.6
-
23
-
-
0342313755
-
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
-
Brdicka T, et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med 2000;191:1591-1604.
-
(2000)
J Exp Med
, vol.191
, pp. 1591-1604
-
-
Brdicka, T.1
-
24
-
-
0034720166
-
Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
-
Kawabuchi M, et al. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000;404:999-1003.
-
(2000)
Nature
, vol.404
, pp. 999-1003
-
-
Kawabuchi, M.1
-
25
-
-
0037105622
-
Cutting edge: Fyn is essential for tyrosine phosphorylation of csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells
-
Yasuda K, et al. Cutting edge: fyn is essential for tyrosine phosphorylation of csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol 2002;169:2813-2817.
-
(2002)
J Immunol
, vol.169
, pp. 2813-2817
-
-
Yasuda, K.1
-
26
-
-
0025881470
-
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src
-
Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 1991;351:69-72.
-
(1991)
Nature
, vol.351
, pp. 69-72
-
-
Nada, S.1
Okada, M.2
MacAuley, A.3
Cooper, J.A.4
Nakagawa, H.5
-
27
-
-
0027240587
-
Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk
-
Chow LM, Fournel M, Davidson D, Veillette A. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 1993;365:156-160.
-
(1993)
Nature
, vol.365
, pp. 156-160
-
-
Chow, L.M.1
Fournel, M.2
Davidson, D.3
Veillette, A.4
-
28
-
-
0034703099
-
Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk
-
Takeuchi S, Takayama Y, Ogawa A, Tamura K, Okada M. Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk. J Biol Chem 2000;275:29183-29186.
-
(2000)
J Biol Chem
, vol.275
, pp. 29183-29186
-
-
Takeuchi, S.1
Takayama, Y.2
Ogawa, A.3
Tamura, K.4
Okada, M.5
-
29
-
-
0035800835
-
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts
-
Torgersen KM, et al. Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J Biol Chem 2001;276:29313-29318.
-
(2001)
J Biol Chem
, vol.276
, pp. 29313-29318
-
-
Torgersen, K.M.1
-
30
-
-
0035955452
-
Interaction between two adaptor proteins, PAG and EBP50: A possible link between membrane rafts and actin cytoskeleton
-
Brolickova N, et al. Interaction between two adaptor proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. FEB3 Lett 2001;501:133-136.
-
(2001)
FEB3 Lett
, vol.501
, pp. 133-136
-
-
Brolickova, N.1
-
31
-
-
0037080345
-
Cutting edge: Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly
-
Itoh K, et al. Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol 2002;168:541-544.
-
(2002)
J Immunol
, vol.168
, pp. 541-544
-
-
Itoh, K.1
-
32
-
-
0030608877
-
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
-
Reczek D, Berryman M, Bretscher A. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol 1997;139:169-179.
-
(1997)
J Cell Biol
, vol.139
, pp. 169-179
-
-
Reczek, D.1
Berryman, M.2
Bretscher, A.3
-
33
-
-
0031043523
-
ERM (ezrin/radixin/moesin) family: From cytoskeleton to signal transduction
-
Tsukita S, Yonemura S. ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr Opin Cell Biol 1997;9:70-75.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 70-75
-
-
Tsukita, S.1
Yonemura, S.2
-
34
-
-
0033583478
-
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation
-
Marie-Cardine A, et al. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med 1999;189:1181-1194.
-
(1999)
J Exp Med
, vol.189
, pp. 1181-1194
-
-
Marie-Cardine, A.1
-
35
-
-
0034974789
-
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)
-
Pfrepper KI, et al. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). Eur J Immunol 2001;31:1825-1836.
-
(2001)
Eur J Immunol
, vol.31
, pp. 1825-1836
-
-
Pfrepper, K.I.1
-
36
-
-
0037195902
-
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling
-
Zhu M, Janssen E, Leung K, Zhang W. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. J Biol Chem 2002.
-
(2002)
J Biol Chem
-
-
Zhu, M.1
Janssen, E.2
Leung, K.3
Zhang, W.4
-
37
-
-
0035083283
-
A soluble LAT deletion mutant inhibits T-cell activation: Reduced recruitment of signalling molecules to glycolipid-enriched microdomains
-
Torgersen KM, Vaage JT, Rolstad B, Tasken K. A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains. Cell Signal 2001;13:213-220.
-
(2001)
Cell Signal
, vol.13
, pp. 213-220
-
-
Torgersen, K.M.1
Vaage, J.T.2
Rolstad, B.3
Tasken, K.4
-
38
-
-
0034614887
-
Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
-
Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med 2000;191:463-474.
-
(2000)
J Exp Med
, vol.191
, pp. 463-474
-
-
Sosinowski, T.1
Pandey, A.2
Dixit, V.M.3
Weiss, A.4
-
39
-
-
0033578408
-
SLAP a dimeric adapter protein, plays a functional role in T cell receptor signaling
-
Tang J, Sawasdikosol S, Chang JH, Burakoff SJ. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. Proc Natl Acad Sci USA 1999;96:9775-9780.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9775-9780
-
-
Tang, J.1
Sawasdikosol, S.2
Chang, J.H.3
Burakoff, S.J.4
-
40
-
-
0034814053
-
The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection
-
Sosinowski T, Killeen N, Weiss A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 2001;15:457-466.
-
(2001)
Immunity
, vol.15
, pp. 457-466
-
-
Sosinowski, T.1
Killeen, N.2
Weiss, A.3
-
41
-
-
0035854665
-
Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70
-
Wang HY, et al. Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. J Biol Chem 2001;276:26004-26011.
-
(2001)
J Biol Chem
, vol.276
, pp. 26004-26011
-
-
Wang, H.Y.1
-
42
-
-
0037166292
-
A novel Src homology 2 domain-containing molecule Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling
-
Pandey A, et al. A novel Src homology 2 domain-containing molecule Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem 2002;277:19131-19138.
-
(2002)
J Biol Chem
, vol.277
, pp. 19131-19138
-
-
Pandey, A.1
-
43
-
-
0035173040
-
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling
-
Holland SJ, et al. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. J Exp Med 2001;194:1263-1276.
-
(2001)
J Exp Med
, vol.194
, pp. 1263-1276
-
-
Holland, S.J.1
-
44
-
-
0036258357
-
Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling
-
Loreto MP, Berry DM, McGlade CJ. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. Mol Cell Biol 2002;22:4241-4255.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4241-4255
-
-
Loreto, M.P.1
Berry, D.M.2
McGlade, C.J.3
-
45
-
-
0032438114
-
Altered thymic positive selection and intracellular signals in Cbl-deficient mice
-
Naramura M, Kole HK, Hu RJ, Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA 1998;95:15547-15552.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15547-15552
-
-
Naramura, M.1
Kole, H.K.2
Hu, R.J.3
Gu, H.4
-
46
-
-
0030812812
-
Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
-
Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science 1997;278:124-128.
-
(1997)
Science
, vol.278
, pp. 124-128
-
-
Boussiotis, V.A.1
Freeman, G.J.2
Berezovskaya, A.3
Barber, D.L.4
Nadler, L.M.5
-
47
-
-
0034642534
-
Cbl-b regulates the CD28 dependence of T-cell activation
-
Chiang YJ, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000;403:216-220.
-
(2000)
Nature
, vol.403
, pp. 216-220
-
-
Chiang, Y.J.1
-
48
-
-
15844388521
-
Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway
-
Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. J Biol Chem 1996;271:12129-12132.
-
(1996)
J Biol Chem
, vol.271
, pp. 12129-12132
-
-
Feng, G.S.1
Ouyang, Y.B.2
Hu, D.P.3
Shi, Z.Q.4
Gentz, R.5
Ni, J.6
-
49
-
-
0031030988
-
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
-
Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem 1997;272:894-902.
-
(1997)
J Biol Chem
, vol.272
, pp. 894-902
-
-
Trub, T.1
Frantz, J.D.2
Miyazaki, M.3
Band, H.4
Shoelson, S.E.5
-
50
-
-
0036240556
-
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction
-
Shen R, et al. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol 2002;22:3230-3236.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3230-3236
-
-
Shen, R.1
-
51
-
-
0035831340
-
Requirement for the SLP-76 adaptor GADS in T cell development
-
Yoder J, et al. Requirement for the SLP-76 adaptor GADS in T cell development. Science 2001;291:1987-1991.
-
(2001)
Science
, vol.291
, pp. 1987-1991
-
-
Yoder, J.1
-
52
-
-
0035810988
-
CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling
-
Yankee TM, Draves KE, Ewings MK, Clark EA, Graves JD. CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling. Proc Natl Acad Sci USA 2001;98:6789-6793.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6789-6793
-
-
Yankee, T.M.1
Draves, K.E.2
Ewings, M.K.3
Clark, E.A.4
Graves, J.D.5
-
53
-
-
0035826112
-
Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor
-
Berry DM, Benn SJ, Cheng AM, McGlade CJ. Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor. Oncogene 2001;20:1203-1211.
-
(2001)
Oncogene
, vol.20
, pp. 1203-1211
-
-
Berry, D.M.1
Benn, S.J.2
Cheng, A.M.3
McGlade, C.J.4
-
54
-
-
0032238298
-
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
-
Gu H, Pratt JC, Burakoff SJ, Neel BG. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell 1998;2:729-740.
-
(1998)
Mol Cell
, vol.2
, pp. 729-740
-
-
Gu, H.1
Pratt, J.C.2
Burakoff, S.J.3
Neel, B.G.4
-
55
-
-
0033559311
-
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
-
Nishida K, et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 1999;93:1809-1816.
-
(1999)
Blood
, vol.93
, pp. 1809-1816
-
-
Nishida, K.1
-
57
-
-
0034021228
-
Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors
-
Hibi M, Hirano T. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. Leuk Lymphoma 2000;37:299-307.
-
(2000)
Leuk Lymphoma
, vol.37
, pp. 299-307
-
-
Hibi, M.1
Hirano, T.2
-
58
-
-
0034667783
-
Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling
-
Pratt JC, et al. Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling. J Immunol 2000;165:4158-4163.
-
(2000)
J Immunol
, vol.165
, pp. 4158-4163
-
-
Pratt, J.C.1
-
59
-
-
0035976967
-
Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules
-
Yamasaki S, et al. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J Biol Chem 2001;276:45175-45183.
-
(2001)
J Biol Chem
, vol.276
, pp. 45175-45183
-
-
Yamasaki, S.1
-
60
-
-
0035968279
-
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
-
Cunnick JM, Mei L, Doupnik CA, Wu J. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. J Biol Chem 2001;276:24380-24387.
-
(2001)
J Biol Chem
, vol.276
, pp. 24380-24387
-
-
Cunnick, J.M.1
Mei, L.2
Doupnik, C.A.3
Wu, J.4
-
61
-
-
0032482171
-
The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells
-
Frearson JA, Alexander DR. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med 1998;187:1417-1426.
-
(1998)
J Exp Med
, vol.187
, pp. 1417-1426
-
-
Frearson, J.A.1
Alexander, D.R.2
-
62
-
-
0035923535
-
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
-
Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl. Acad Sci USA 2001;98:13866-13871.
-
(2001)
Proc Natl. Acad Sci USA
, vol.98
, pp. 13866-13871
-
-
Okazaki, T.1
Maeda, A.2
Nishimura, H.3
Kurosaki, T.4
Honjo, T.5
-
63
-
-
0031944075
-
NK cell receptors
-
Lanier LL. NK cell receptors. Annu Rev Immunol 1998;16:359-393.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 359-393
-
-
Lanier, L.L.1
-
64
-
-
0032545452
-
Molecular basis of T cell inactivation by CTLA-4
-
Lee KM, et al. Molecular basis of T cell inactivation by CTLA-4. Science 1998;282:2263-2266.
-
(1998)
Science
, vol.282
, pp. 2263-2266
-
-
Lee, K.M.1
-
65
-
-
0034717590
-
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
-
Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol 2000;149:1419-1432.
-
(2000)
J Cell Biol
, vol.149
, pp. 1419-1432
-
-
Schaeper, U.1
Gehring, N.H.2
Fuchs, K.P.3
Sachs, M.4
Kempkes, B.5
Birchmeier, W.6
-
66
-
-
0035985205
-
Distinct recruitment and function of Gab1 and Gab2 in met receptor-mediated epithelial morphogenesis
-
Lock LS, Maroun CR, Naujokas MA, Park M. distinct recruitment and function of Gab1 and Gab2 in met receptor-mediated epithelial morphogenesis. Mol Biol Cell 2002;13:2132-2146.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 2132-2146
-
-
Lock, L.S.1
Maroun, C.R.2
Naujokas, M.A.3
Park, M.4
-
67
-
-
0034613198
-
Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
-
Lock LS, Royal I, Naujokas MA, Park M. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. J Biol Chem 2000;275:31536-31545.
-
(2000)
J Biol Chem
, vol.275
, pp. 31536-31545
-
-
Lock, L.S.1
Royal, I.2
Naujokas, M.A.3
Park, M.4
-
68
-
-
0032489913
-
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
-
Weber JR, et al. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med 1998;187:1157-1161.
-
(1998)
J Exp Med
, vol.187
, pp. 1157-1161
-
-
Weber, J.R.1
-
69
-
-
0034646610
-
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
-
Sakkab D, et al. Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem 2000;275:10772-10778.
-
(2000)
J Biol Chem
, vol.275
, pp. 10772-10778
-
-
Sakkab, D.1
-
70
-
-
0037080536
-
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
-
Lynch DK, Daly RJ. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBOJ 2002;21:72-82.
-
(2002)
EMBOJ
, vol.21
, pp. 72-82
-
-
Lynch, D.K.1
Daly, R.J.2
Yamanashi, Y.3
-
71
-
-
0033979324
-
Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling
-
Yamanashi Y, et al. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev 2000;14:11-16.
-
(2000)
Genes Dev
, vol.14
, pp. 11-16
-
-
Yamanashi, Y.1
-
72
-
-
0031444245
-
Identification of the Ab1- and rasGAP-associated 62 kDa protein as a docking protein, Dok
-
Yamanashi Y, Baltimore D. Identification of the Ab1- and rasGAP-associated 62 kDa protein as a docking protein, Dok. cell 1997;88:205-211.
-
(1997)
Cell
, vol.88
, pp. 205-211
-
-
Yamanashi, Y.1
Baltimore, D.2
-
73
-
-
0032126362
-
FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation
-
Nelms K, Snow AL, Hu-Li J, Paul WE. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity 1998;9:13-24.
-
(1998)
Immunity
, vol.9
, pp. 13-24
-
-
Nelms, K.1
Snow, A.L.2
Hu-Li, J.3
Paul, W.E.4
-
74
-
-
0034029126
-
Dok-3, a novel adapter molecule revolved in the negative regulation of immunoreceptor signaling
-
Lemay S, Davidson D, Latour S, Veillette A. Dok-3, a novel adapter molecule revolved in the negative regulation of immunoreceptor signaling. Mol Cell Biol 2000;20:2743-2754.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2743-2754
-
-
Lemay, S.1
Davidson, D.2
Latour, S.3
Veillette, A.4
-
75
-
-
19044372472
-
Critical role for Gab2 in transformation by BCR/ABL
-
Sattler M, et al. Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 2002;1:479-492.
-
(2002)
Cancer Cell
, vol.1
, pp. 479-492
-
-
Sattler, M.1
-
76
-
-
0036091398
-
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation
-
Bourgin C, Bourette KP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. Mol Cell Biol 2002;22:3744-3756.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3744-3756
-
-
Bourgin, C.1
Bourette, K.P.2
Arnaud, S.3
Liu, Y.4
Rohrschneider, L.R.5
Mouchiroud, G.6
-
77
-
-
0035056017
-
CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
-
Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001;19:565-594.
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 565-594
-
-
Chambers, C.A.1
Kuhns, M.S.2
Egen, J.G.3
Allison, J.P.4
-
78
-
-
0035059417
-
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
-
Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001;19:225-252.
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 225-252
-
-
Salomon, B.1
Bluestone, J.A.2
-
79
-
-
0036170440
-
Activation and inhibition of lymphocytes by costimulation
-
Frauwirth KA, Thompson CB. Activation and inhibition of lymphocytes by costimulation. J Clin Invest 2002;109:295-299.
-
(2002)
J Clin Invest
, vol.109
, pp. 295-299
-
-
Frauwirth, K.A.1
Thompson, C.B.2
-
81
-
-
0027282960
-
Characterization of CTLA-4 structure and expression on human T cells
-
Lindsten T, et al. Characterization of CTLA-4 structure and expression on human T cells. J Immunol 1993;151:3489-3499.
-
(1993)
J Immunol
, vol.151
, pp. 3489-3499
-
-
Lindsten, T.1
-
82
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994;1:405-413.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
-
83
-
-
0034679567
-
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
-
Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
-
(2000)
J Exp Med
, vol.192
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
84
-
-
0034679560
-
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
Takahashi T, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192:303-310.
-
(2000)
J Exp Med
, vol.192
, pp. 303-310
-
-
Takahashi, T.1
-
85
-
-
0037123607
-
Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
-
Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 2002;296:1323-1326.
-
(2002)
Science
, vol.296
, pp. 1323-1326
-
-
Arase, H.1
Mocarski, E.S.2
Campbell, A.E.3
Hill, A.B.4
Lanier, L.L.5
-
86
-
-
0034895245
-
Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family
-
Takai T, Ono M. Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family. Immunol Rev 2001;181:215-222.
-
(2001)
Immunol Rev
, vol.181
, pp. 215-222
-
-
Takai, T.1
Ono, M.2
-
87
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996;183:2533-2540.
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
88
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
-
Waterhouse P, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995;270:985-988.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
-
89
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-547.
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
90
-
-
0034721737
-
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
-
Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 2000;290:816-819.
-
(2000)
Science
, vol.290
, pp. 816-819
-
-
Ostrov, D.A.1
Shi, W.2
Schwartz, J.C.3
Almo, S.C.4
Nathenson, S.G.5
-
91
-
-
0036172220
-
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
-
Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002;16:23-35.
-
(2002)
Immunity
, vol.16
, pp. 23-35
-
-
Egen, J.G.1
Allison, J.P.2
-
92
-
-
0037141091
-
Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
-
Darlington PJ, et al. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J Exp Med 2002;195:1337-1347.
-
(2002)
J Exp Med
, vol.195
, pp. 1337-1347
-
-
Darlington, P.J.1
-
93
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 1996; 183:2541-2550.
-
(1996)
J Exp Med
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
94
-
-
0033563271
-
CTLA-4-mediated inhibition of early events of T cell proliferation
-
Brunner MC, Chambers CA, Chan FK, Hanke J, Winoto A, Allison JP. CTLA-4-mediated inhibition of early events of T cell proliferation. J Immunol 1999;162:5813-5820.
-
(1999)
J Immunol
, vol.162
, pp. 5813-5820
-
-
Brunner, M.C.1
Chambers, C.A.2
Chan, F.K.3
Hanke, J.4
Winoto, A.5
Allison, J.P.6
-
95
-
-
0033588874
-
Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail
-
Nakaseko C, et al. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail. J Exp Med 1999;190:765-774.
-
(1999)
J Exp Med
, vol.190
, pp. 765-774
-
-
Nakaseko, C.1
-
96
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
Marengere LE, Waterhouse P, Duncan GS, Mittrucker HW, Feng GS, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996;272:1170-1173.
-
(1996)
Science
, vol.272
, pp. 1170-1173
-
-
Marengere, L.E.1
Waterhouse, P.2
Duncan, G.S.3
Mittrucker, H.W.4
Feng, G.S.5
Mak, T.W.6
-
97
-
-
0030707866
-
2-terminal kmase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP-70
-
2-terminal kmase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP-70. J Exp Med 1997;186:1645-1653.
-
(1997)
J Exp Med
, vol.186
, pp. 1645-1653
-
-
Calvo, C.R.1
Amsen, D.2
Kruisbeek, A.M.3
-
98
-
-
0034254301
-
CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
-
Carreno BM, et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol 2000;165:1352-1356.
-
(2000)
J Immunol
, vol.165
, pp. 1352-1356
-
-
Carreno, B.M.1
-
99
-
-
0033985191
-
The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
-
Baroja ML, et al. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol 2000;164:49-55.
-
(2000)
J Immunol
, vol.164
, pp. 49-55
-
-
Baroja, M.L.1
-
100
-
-
0036569236
-
CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: A potential role for tyrosine phosphatases
-
Guntermann C, Alexander DR. CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J Immunol 2002;168:4420-4429.
-
(2002)
J Immunol
, vol.168
, pp. 4420-4429
-
-
Guntermann, C.1
Alexander, D.R.2
-
101
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA 1997;94:9273-9278.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
-
102
-
-
0034086694
-
Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4
-
Chikuma S, Murakami M, Tanaka K, Uede T. Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4. J Cell Biochem 2000;78:241-250.
-
(2000)
J Cell Biochem
, vol.78
, pp. 241-250
-
-
Chikuma, S.1
Murakami, M.2
Tanaka, K.3
Uede, T.4
-
103
-
-
0033662376
-
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
-
Chuang E, et al. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 2000;13:313-322.
-
(2000)
Immunity
, vol.13
, pp. 313-322
-
-
Chuang, E.1
-
104
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
Shiratori T, et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997;6:583-589.
-
(1997)
Immunity
, vol.6
, pp. 583-589
-
-
Shiratori, T.1
-
105
-
-
0031181647
-
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
-
Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol 1997;159:144-151.
-
(1997)
J Immunol
, vol.159
, pp. 144-151
-
-
Chuang, E.1
Alegre, M.L.2
Duckett, C.S.3
Noel, P.J.4
Vander Heiden, M.G.5
Thompson, C.B.6
-
106
-
-
0031471027
-
Interaction of the cytoplasmic tail of CTLA-4 (CD 152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
-
Bradshaw JD, et al. Interaction of the cytoplasmic tail of CTLA-4 (CD 152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation. Biochemistry 1997;36:15975-15982.
-
(1997)
Biochemistry
, vol.36
, pp. 15975-15982
-
-
Bradshaw, J.D.1
-
107
-
-
0033567050
-
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
-
Schneider H, et al. Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol 1999;163:1868-1879.
-
(1999)
J Immunol
, vol.163
, pp. 1868-1879
-
-
Schneider, H.1
-
108
-
-
0028840355
-
Interaction of tyrosine-based sorting signals with clathrin-associated proteins
-
Ohno H, et al. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 1995;269:1872-1875.
-
(1995)
Science
, vol.269
, pp. 1872-1875
-
-
Ohno, H.1
-
109
-
-
0031861620
-
Negative regulation of T cell activation
-
Saito T. Negative regulation of T cell activation. Curr Opin Immunol 1998;10:313-321.
-
(1998)
Curr Opin Immunol
, vol.10
, pp. 313-321
-
-
Saito, T.1
-
110
-
-
0032547259
-
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)
-
Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152). Biochem Biophys Res Commun 1998;249:444-448.
-
(1998)
Biochem Biophys Res Commun
, vol.249
, pp. 444-448
-
-
Miyatake, S.1
Nakaseko, C.2
Umemori, H.3
Yamamoto, T.4
Saito, T.5
-
111
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996;4:535-543.
-
(1996)
Immunity
, vol.4
, pp. 535-543
-
-
Linsley, P.S.1
Bradshaw, J.2
Greene, J.3
Peach, R.4
Bennett, K.L.5
Mittler, R.S.6
-
112
-
-
0034327809
-
Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
-
Iida T, et al. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J Immunol 2000;165:5062-5068.
-
(2000)
J Immunol
, vol.165
, pp. 5062-5068
-
-
Iida, T.1
-
113
-
-
0033587676
-
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation
-
Barrat FJ, et al. Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. Proc Natl Acad Sci USA 1999;96:8645-8650.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8645-8650
-
-
Barrat, F.J.1
-
114
-
-
0030966217
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
-
Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997;6:411-417.
-
(1997)
Immunity
, vol.6
, pp. 411-417
-
-
Perez, V.L.1
Van Parijs, L.2
Biuckians, A.3
Zheng, X.X.4
Strom, T.B.5
Abbas, A.K.6
-
115
-
-
0035102196
-
CTLA-4 regulates Induction of anergy in vivo
-
Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates Induction of anergy in vivo. Immunity 2001;14:145-155.
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
116
-
-
0034653393
-
Induction of T cell allergy in the absence of CTLA-4/B7 interaction
-
Frauwirth KA, Alegre ML, Thompson CB. Induction of T cell allergy in the absence of CTLA-4/B7 interaction. J Immunol 2000;164:2987-2993.
-
(2000)
J Immunol
, vol.164
, pp. 2987-2993
-
-
Frauwirth, K.A.1
Alegre, M.L.2
Thompson, C.B.3
-
117
-
-
0037103325
-
Re-establishing peripheral tolerance in the absence of CTLA-4: Complementation by wild-type T cells points to an indirect role for CTLA-4
-
Tivol EA, Gorski J. Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4. J Immunol 2002;169:1852-1858.
-
(2002)
J Immunol
, vol.169
, pp. 1852-1858
-
-
Tivol, E.A.1
Gorski, J.2
-
118
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11:3887-3895.
-
(1992)
EMBO J
, vol.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
119
-
-
0034610980
-
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice
-
Nishimura H, Honjo T, Minato N. Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. J Exp Med 2000;191:891-898.
-
(2000)
J Exp Med
, vol.191
, pp. 891-898
-
-
Nishimura, H.1
Honjo, T.2
Minato, N.3
-
120
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
Nishimura H, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001;291:319-322.
-
(2001)
Science
, vol.291
, pp. 319-322
-
-
Nishimura, H.1
-
122
-
-
5844264920
-
PD-L2 is a second ligand for PD-I and inhibits T cell activation
-
Latchman Y, et al. PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat Immunol 2001;2:261-268.
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
-
123
-
-
0029066263
-
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
-
Tarakhovsky A, et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 1995;269:535-537.
-
(1995)
Science
, vol.269
, pp. 535-537
-
-
Tarakhovsky, A.1
-
124
-
-
0032936299
-
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway. Involvement of SH2-containing phosphotyrosine phosphatase SHP-1
-
Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, Aruffo AA, Kanner SB. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway. Involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol 1999;19:2903-2912.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2903-2912
-
-
Perez-Villar, J.J.1
Whitney, G.S.2
Bowen, M.A.3
Hewgill, D.H.4
Aruffo, A.A.5
Kanner, S.B.6
-
125
-
-
0032190081
-
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
-
Sayos J, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 1998;395:462-469.
-
(1998)
Nature
, vol.395
, pp. 462-469
-
-
Sayos, J.1
-
126
-
-
0034889004
-
Veillette A Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
-
Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol 2001;2:681-690.
-
(2001)
Nat Immunol
, vol.2
, pp. 681-690
-
-
Latour, S.1
Gish, G.2
Helgason, C.D.3
Humphries, R.K.4
Pawson, T.5
-
127
-
-
0030761022
-
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
-
Meyaard L, et al. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 1997;7:283-290.
-
(1997)
Immunity
, vol.7
, pp. 283-290
-
-
Meyaard, L.1
-
128
-
-
0030716868
-
The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)
-
Sagawa K, Kimura T, Swieter M, Siraganian RP. The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). J Biol Chem 1997;272:31086-31091.
-
(1997)
J Biol Chem
, vol.272
, pp. 31086-31091
-
-
Sagawa, K.1
Kimura, T.2
Swieter, M.3
Siraganian, R.P.4
-
129
-
-
0033565294
-
A new role for platelet-endothelial cell adhesion molecule- 1 (CD31): Inhibition of TCR-mediated signal transduction
-
Newton-Nash DK, Newman PJ. A new role for platelet-endothelial cell adhesion molecule- 1 (CD31): inhibition of TCR-mediated signal transduction. J Immunol 1999;163:682-688.
-
(1999)
J Immunol
, vol.163
, pp. 682-688
-
-
Newton-Nash, D.K.1
Newman, P.J.2
-
130
-
-
0035871812
-
Inhibition of antigen-receptor signaling by platelet endothehal cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck)
-
Newman DK, Hamilton C, Newman PJ. Inhibition of antigen-receptor signaling by platelet endothehal cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck). Blood 2001;97:2351-2357.
-
(2001)
Blood
, vol.97
, pp. 2351-2357
-
-
Newman, D.K.1
Hamilton, C.2
Newman, P.J.3
-
131
-
-
0036167828
-
Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice
-
Graesser D, et al. Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest 2002;109:383-392.
-
(2002)
J Clin Invest
, vol.109
, pp. 383-392
-
-
Graesser, D.1
-
132
-
-
0035865379
-
Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization
-
Dietrich J, Cella M, Colonna M. Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization. J Immunol 2001;166:2514-2521.
-
(2001)
J Immunol
, vol.166
, pp. 2514-2521
-
-
Dietrich, J.1
Cella, M.2
Colonna, M.3
-
133
-
-
0035794318
-
Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk)
-
Schmedt C, Tarakhovsky A. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 2001;193:815-826.
-
(2001)
J Exp Med
, vol.193
, pp. 815-826
-
-
Schmedt, C.1
Tarakhovsky, A.2
-
134
-
-
0035194916
-
Mutation of Tec family kinases alters T helper cell differentiation
-
Schaeffer EM, et al. Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol 2001;2:1183-1188.
-
(2001)
Nat Immunol
, vol.2
, pp. 1183-1188
-
-
Schaeffer, E.M.1
-
135
-
-
0034596946
-
Tec family kinases modulate thresholds for thymocyte development and selection
-
Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL. Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med 2000;192:987-1000.
-
(2000)
J Exp Med
, vol.192
, pp. 987-1000
-
-
Schaeffer, E.M.1
Broussard, C.2
Debnath, J.3
Anderson, S.4
McVicar, D.W.5
Schwartzberg, P.L.6
-
136
-
-
0029844309
-
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
-
Lorenz U, Ravichandran KS, Burakoff SJ, Neel BG. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci USA 1996;93:9624-9629.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9624-9629
-
-
Lorenz, U.1
Ravichandran, K.S.2
Burakoff, S.J.3
Neel, B.G.4
-
137
-
-
0032968708
-
The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
-
Germain RN, Stefanova I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu Rev Immunol 1999;17:467-522.
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 467-522
-
-
Germain, R.N.1
Stefanova, I.2
-
138
-
-
0034948374
-
Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts
-
Kosugi A, Sakakura J, Yasuda K, Ogata M, Hamaoka T, Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 2001;14:669-680.
-
(2001)
Immunity
, vol.14
, pp. 669-680
-
-
Kosugi, A.1
Sakakura, J.2
Yasuda, K.3
Ogata, M.4
Hamaoka, T.5
-
139
-
-
0033567943
-
Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection
-
Zhang J, Somani AK, Yuen D, Yang Y, Love PE, Siminovitch KA. Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. J Immunol 1999;163:3012-3021.
-
(1999)
J Immunol
, vol.163
, pp. 3012-3021
-
-
Zhang, J.1
Somani, A.K.2
Yuen, D.3
Yang, Y.4
Love, P.E.5
Siminovitch, K.A.6
-
140
-
-
0033521596
-
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
-
Cloutier JF, Veillette A. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 1999:189:111-121.
-
(1999)
J Exp Med
, vol.189
, pp. 111-121
-
-
Cloutier, J.F.1
Veillette, A.2
-
141
-
-
0035141252
-
SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF
-
Wang B, Lemay S, Tsai S, Veillette A. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol Cell Biol 2001;21:1077-1088.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1077-1088
-
-
Wang, B.1
Lemay, S.2
Tsai, S.3
Veillette, A.4
-
142
-
-
0035102841
-
Protein tyrosme phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgammal phosphorylation
-
Baker JE, Majeti R, Tangye SG, Weiss A. Protein tyrosme phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgammal phosphorylation. Mol Cell Biol 2001;21:2393-2403.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2393-2403
-
-
Baker, J.E.1
Majeti, R.2
Tangye, S.G.3
Weiss, A.4
-
143
-
-
0034108451
-
Cytoskeletal protein tyrosine phosphatase PTPH1 reduced T cell antigen receptor signaling
-
Hans S, Williams S, Mustelin T. Cytoskeletal protein tyrosine phosphatase PTPH1 reduced T cell antigen receptor signaling. Eur J Immunol 2000;30:1318-1325.
-
(2000)
Eur J Immunol
, vol.30
, pp. 1318-1325
-
-
Hans, S.1
Williams, S.2
Mustelin, T.3
-
144
-
-
0032546961
-
Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP)
-
Saxena M, Williams S, Gilman J, Mustelin T. Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP). J Biol Chem 1998;273:15340-15344.
-
(1998)
J Biol Chem
, vol.273
, pp. 15340-15344
-
-
Saxena, M.1
Williams, S.2
Gilman, J.3
Mustelin, T.4
-
146
-
-
0034995242
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance
-
Suzuki A, et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 2001;14:523-534.
-
(2001)
Immunity
, vol.14
, pp. 523-534
-
-
Suzuki, A.1
-
147
-
-
0034600901
-
Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3
-
Ohteki T, et al. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med 2000;192:99-104.
-
(2000)
J Exp Med
, vol.192
, pp. 99-104
-
-
Ohteki, T.1
-
148
-
-
0033711185
-
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
-
Liou J, et al. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity 2000;12:399-408.
-
(2000)
Immunity
, vol.12
, pp. 399-408
-
-
Liou, J.1
-
149
-
-
0037163130
-
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta
-
Zhong XP, Hainey EA, Olenchock BA, Zhao H, Topham MK, Koretzky GA. Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem 2002;277:31089-31098.
-
(2002)
J Biol Chem
, vol.277
, pp. 31089-31098
-
-
Zhong, X.P.1
Hainey, E.A.2
Olenchock, B.A.3
Zhao, H.4
Topham, M.K.5
Koretzky, G.A.6
-
150
-
-
0035911971
-
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism
-
Topham MK, Prescott SM. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. J Cell Biol 2001;152:1135-1143.
-
(2001)
J Cell Biol
, vol.152
, pp. 1135-1143
-
-
Topham, M.K.1
Prescott, S.M.2
|