Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors

Leukemia and Lymphoma

Volumn 37, Issue 3-4, 2000, Pages 299-307

  Hibi, Masahiko ^a   Hirano, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

B cell receptor; Cytokine receptor; Gab1; Gab2; Receptor tyrosine kinase; T cell receptor

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN GAB 2; PROTEIN GAB1; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING SITE; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0034021228     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190009089430     Document Type: Review

References (49)

1. Heldin, C.H. (1995) Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.
2. IhIe, J.N. (1995) Cytokine receptor signalling. Nature 377, 591-594.
3. Pawson, T. & Scott, J.D. (1997) Signaling through scaffold, anchoring, and adaptor proteins. Science 278, 2075-2080.
4. Fu, C., Turck, C.W., Kurosaki, T. & Chan, A.C. (1998) BLNK: a central linker protein in B cell activation. Immunity 9, 93-103.
5. Pivniouk, V. et al. (1998) Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94, 229-238.
6. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P. & Samelson, L.E. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92, 83-92.
7. Rudd, C.E. (1999) Adaptors and molecular scaffolds in immune cell signaling. Cell 96, 5-8.
8. Gu, H., Pratt, J.C., Burakoff, S.J. & Neel, B.C. (1998) Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell 2, 729-740.
9. Nishida, K. et al. (1999) Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T-and B-cell antigen receptors. Blood 93, 1809-1816.
10. Huyer, G. & Alexander, D.R. (1999) Immune signalling: SHP-2 docks at multiple ports. Curr Biol 9, R129-132.
11. Adachi, M. et al. (1996) Mammalian SH2-containing protein tyrosine phosphatases [letter]. Cell 85, 15.
12. Feng, G.S., Hui, C.C. & Pawson, T. (1993) SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259, 1607-1611.
13. Vogel, W., Lammers, R., Huang, J. & Ullrich, A. (1993) Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259, 1611-1614.
14. Bennett, A.M., Tang, T.L., Sugimoto, S., Walsh, C.T. & Neel, B.G. (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc Natl Acad Sci USA 91, 7335-7339.
15. Li, W. et al. (1994) A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14, 509-517.
16. Ali, S. et al. (1996) PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. Embo J 15, 135-142.
17. David, M., Zhou, G., Pine, R., Dixon, J.E & Larner, A.C. (1996) The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression. J Biol Chem 271, 15862-15865.
18. Itoh, T. et al. (1996) Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling. J Biol Chem 271, 7587-7592.
19. Fukada, T. et al. (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5, 449-460.
20. Hirano, T., Nakajima, K. & Hibi, M. (1997) Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev 8, 241-252.
21. Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. & Kasuga, M. (1994) Role of SH-FTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol Cell Biol 14, 6674-6682.
22. Bennett, A.M., Hausdorff, S.F., O'Reilly, A.M., Freeman, R.M. & Neel, B.G. (1996) Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol Cell Biol 16, 1189-1202.
23. Tang, T.L., Freeman, R.M., Jr., O'Reilly, A.M., Neel, B.C. & Sokol, S.Y. (1995) The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80, 473-483.
24. Frearson, J.A. & Alexander, D.R. (1998) The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med 187, 1417-1426.
25. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386, 181-186.
26. Fujioka, Y. et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 16, 6887-6899.
27. Welham, M.J. et al. (1997) Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells. J Biol Chem 272, 1377-1381.
28. Holgado-Madruga, M., Emlet, D.R., Moscatello, D.K., Godwin, A.K. & Wong, A.J. (1996) A Grb2-associated docking protein in EGF-and insulin-receptor signalling. Nature 379, 560-564.
29. Zhao, C., Yu, D.H., Shen, R. & Feng, G.S. (1999) Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem 274, 19649-19654.
30. Perkins, L.A., Larsen, I. & Perrimon, N. (1992) corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70, 225-236.
31. Perkins, L.A., Johnson, M.R., Melnick, M.B. & Perrimon, N. (1996) The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol 180, 63-81.
32. Allard, J.D., Chang, H.C., Herbst, R., McNeill, H. & Simon, M.A. (1996) The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122, 1137-1146.
33. Allard, J.D., Herbst, R., Carroll, P.M. & Simon, M.A. (1998) Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. J Biol Chem 273, 13129-13135.
34. Herbst, R. et al. (1996) Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85, 899-909.
35. Raabe, T. et al. (1996) DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell 85, 911-920.
36. Gutch, M.J., Flint, A.J., Keller, J., Tonks, N.K. & Hengartner, M.O. (1998) The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev 12, 571-585.
37. Burdon, T., Stracey, C., Chambers, I., Nichols, J. & Smith, A. (1999) Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 210, 30-43.
38. Weidner, K.M. et al. (1996) Interaction between Gabi and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.
39. Bardelli, A., Longati, P., Gramaglia, D., Stella, M.C. & Comoglio, P. M. (1997) Gabi coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene 15, 3103-3111.
40. Daub, H., Wallasch, C., Lankenau, A., Herrlich, A. & Ullrich, A. (1997) Signal characteristics of G protein-transactivated EGF receptor. Embo J 16, 7032-7044.
41. Holgado-Madruga, M., Moscatello, D.K., Emlet, D.R., Dieterich, R. & Wong, A.J. (1997) Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion ol cell survival by nerve growth factor. Proc Natl Acad Sci U S A 94, 12419-12424.
42. Takahashi-Tezuka, M. et al. (1998) Gabi acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol Cell Biol 18, 4109-4117.
43. Murakami, H. et al. (1999) Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation. Biochem Biophys Res Commun 262, 68-75.
44. Ireton, K., Payrastre, B. & Cossart, P. (1999) The Listeria monocytogenes protein InIB is an agonist of mammalian phosphoinositide 3-kmase. J Biol Chem 274, 17025-17032.
45. Lehr, S. et al. (1999) Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry 38, 151-159.
46. Tulasne, D., Paumelle, R., Weidner, K.M., Vandenbunder, B. & Fafeur, V. (1999) The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. Mol Biol Cell 10, 551-565.
47. Maroun, C.R. et al. (1999) The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol 19, 1784-1799.
48. Niemann, C. et al. (1998) Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol 143, 533-545.
49. Wickrema, A. et al. (1999) Engagement of Gabi and Gab2 in Erythropoietin Signaling. J Biol Chem 274, 24469-24474.