The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection

Immunity

Volumn 15, Issue 3, 2001, Pages 457-466

  Sosinowski, Tomasz ^a   Killeen, Nigel ^a   Weiss, Arthur ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENETIC SELECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0034814053     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00195-9     Document Type: Article

References (73)

1. Positive selection of thymocytes: The long and winding road
2. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase
3. Evidence for a differential avidity model of T cell selection in the thymus
4. A differential-avidity model for T cell selection
5. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
6. Activation events during thymic selection
7. Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment
8. T cell-specific deletion of T cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes
9. Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4
10. Exclusion and inclusion of alpha and beta T cell receptor alleles
11. Activation-induced ubiquitination of the T cell antigen receptor
12. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells
13. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
14. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression
15. Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo
16. Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages
17. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation
18. Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection
19. Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors
20. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
21. Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus
22. Limits to the differential avidity model of T cell selection in the thymus
23. Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase
24. Mice lacking MHC class II molecules
25. T cell receptor antagonist peptides induce positive selection
26. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase
27. Differential requirements for ZAP-70 in TCR signaling and T cell development
28. Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells
29. Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture
30. Negative selection in the thymus includes semimature T cells
31. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
32. Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts
33. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
34. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
35. Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage
36. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation
37. Inverse correlation between steady-state RNA and cell surface T cell receptor levels
38. Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes
39. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
40. The effect of thymus environment on T cell development and tolerance
41. Engagement of the CD4 molecule influences cell surface expression of the T cell receptor on thymocytes
42. How many thymocytes audition for selection?
43. Profound block in thymocyte development in mice lacking p56lck
44. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
45. Tissue hyperplasia and enhanced T cell signalling via ZAP-70 in c-Cbl-deficient mice
46. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
47. Essential role for ZAP-70 in both positive and negative selection of thymocytes
48. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
49. Negative regulation of CD4 lineage development and responses by CD5
50. Gene targeting in embryonic stem cells
51. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex
52. Src-like adaptor protein (Slap) is a negative regulator of mitogenesis
53. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement
54. Mature T cell reactivity altered by peptide agonist that induces positive selection
55. Selection of the T cell repertoire
56. Positive and negative thymocyte selection induced by different concentrations of a single peptide
57. Role of TCR zeta chain in T cell development and selection
58. The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: Delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells
59. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
60. CD69 expression during selection and maturation of CD4+8+ thymocytes
61. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling
62. A role for CD5 in TCR-mediated signal transduction and thymocyte selection
63. Lymphocyte populations and immune responses in CD5-deficient mice
64. Development of mature CD8+ thymocytes: Selection rather than instruction?
65. Alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases
66. T cell activation determined by T cell receptor number and tunable thresholds
67. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene
68. TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck
69. Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?
70. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
71. The agonist-antagonist balance in positive selection
72. Analysis of immature (CD4-CD8-) thymic subsets in T cell receptor alpha beta transgenic mice
73. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection