-
1
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptor
-
Weiss A, Litman DR. Signal transduction by lymphocyte antigen receptor. Cell. 76:1994;263-274.
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Litman, D.R.2
-
3
-
-
0031026454
-
Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent CD28-independent signal pathway
-
Reinhold MI, Lindberg FP, Kersh GJ, Allen PM, Brown EJ. Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent CD28-independent signal pathway. J Exp Med. 185:1997;1-11.
-
(1997)
J Exp Med
, vol.185
, pp. 1-11
-
-
Reinhold, M.I.1
Lindberg, F.P.2
Kersh, G.J.3
Allen, P.M.4
Brown, E.J.5
-
4
-
-
10144245925
-
A role of CD9 molecules in T cell activation
-
Tai XG, Yashiro Y, Abe R, Toyooka K, Wood CR, Morris J, Long A, Ono S, Kobayashi M, Hamaoka T, et al. A role of CD9 molecules in T cell activation. J Exp Med. 184:1996;753-758.
-
(1996)
J Exp Med
, vol.184
, pp. 753-758
-
-
Tai, X.G.1
Yashiro, Y.2
Abe, R.3
Toyooka, K.4
Wood, C.R.5
Morris, J.6
Long, A.7
Ono, S.8
Kobayashi, M.9
Hamaoka, T.10
-
6
-
-
0027937702
-
Complementary determining region 1(CDR-1)- And CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
-
Peach RJ, Bajorath J, Brady W, Letze G, Greeene J, Naemura J, Linsley PS. Complementary determining region 1(CDR-1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J Exp Med. 180:1994;2049-2058.
-
(1994)
J Exp Med
, vol.180
, pp. 2049-2058
-
-
Peach, R.J.1
Bajorath, J.2
Brady, W.3
Letze, G.4
Greeene, J.5
Naemura, J.6
Linsley, P.S.7
-
7
-
-
0031054242
-
CD80(B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
-
of special interest. This reports that monomeric CTLA-4 (cytotoxic T lymphocyte antigen 4) and CD28 have much lower ligand affinity than was previously believed and that the avidity of CTLA-4 for B7 is much higher than that of CD28.
-
Van der Merwe PA, Bodian DL, Daenke S, Linsley PS, Davis SJ. CD80(B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. of special interest J Exp Med. 185:1997;393-404 This reports that monomeric CTLA-4 (cytotoxic T lymphocyte antigen 4) and CD28 have much lower ligand affinity than was previously believed and that the avidity of CTLA-4 for B7 is much higher than that of CD28.
-
(1997)
J Exp Med
, vol.185
, pp. 393-404
-
-
Van Der Merwe, P.A.1
Bodian, D.L.2
Daenke, S.3
Linsley, P.S.4
Davis, S.J.5
-
8
-
-
0029914089
-
Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell co-stimulatory interactions
-
of special interest. This report provides an implication that the high avidity of cytotoxic T lymphocyte antigen 4 (CTLA-4) is produced by CTLA-4 homodimer formation and B7 clustering (see also Van der Merwe et al., 1997 [7]).
-
Greene JL, Leytze GM, Emswiler J, Peach R, Bajorath J, Cosand W, Linsley PS. Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell co-stimulatory interactions. of special interest J Biol Chem. 271:1996;26762-26771 This report provides an implication that the high avidity of cytotoxic T lymphocyte antigen 4 (CTLA-4) is produced by CTLA-4 homodimer formation and B7 clustering (see also Van der Merwe et al., 1997 [7]).
-
(1996)
J Biol Chem
, vol.271
, pp. 26762-26771
-
-
Greene, J.L.1
Leytze, G.M.2
Emswiler, J.3
Peach, R.4
Bajorath, J.5
Cosand, W.6
Linsley, P.S.7
-
9
-
-
0026486220
-
Coexpression and functional cooperativity of CTLA-4 and CD28 on activated T lymphocytes
-
Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK. Coexpression and functional cooperativity of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med. 176:1992;1595-1604.
-
(1992)
J Exp Med
, vol.176
, pp. 1595-1604
-
-
Linsley, P.S.1
Greene, J.L.2
Tan, P.3
Bradshaw, J.4
Ledbetter, J.A.5
Anasetti, C.6
Damle, N.K.7
-
10
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walnas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GL, Green JM, Thompson CB, Bluestone JA. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:1994;405-413.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walnas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
Linsley, P.S.4
Freeman, G.L.5
Green, J.M.6
Thompson, C.B.7
Bluestone, J.A.8
-
11
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 182:1995;459-465.
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
13
-
-
0030586626
-
CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
-
Perrin PJ, Maldonado JH, Davis TA, June CH, Racke MK. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J Immunol. 157:1996;1333-1336.
-
(1996)
J Immunol
, vol.157
, pp. 1333-1336
-
-
Perrin, P.J.1
Maldonado, J.H.2
Davis, T.A.3
June, C.H.4
Racke, M.K.5
-
14
-
-
0029947568
-
Enhancement of antitumor Immunity by CTLA-4 blockade
-
of outstanding interest. This reported for the first time that the in vivo administration of antibodies against the cytotoxic T lymphocyte antigen 4 (CTLA-4) augmented the antitumor immune response in mice.
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor Immunity by CTLA-4 blockade. of outstanding interest Science. 271:1996;1734-1736 This reported for the first time that the in vivo administration of antibodies against the cytotoxic T lymphocyte antigen 4 (CTLA-4) augmented the antitumor immune response in mice.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
15
-
-
0345368071
-
Is CTLA-4 a negative regulator for T-cell activation?
-
Lin Y. Is CTLA-4 a negative regulator for T-cell activation? Immunol Today. 18:1997;569-572.
-
(1997)
Immunol Today
, vol.18
, pp. 569-572
-
-
Lin, Y.1
-
16
-
-
0028791059
-
CTLA-4 deficiency causes lymphoproliferative disorder with early lethality
-
Waterhous P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW. CTLA-4 deficiency causes lymphoproliferative disorder with early lethality. Science. 270:1995;985-988.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhous, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
Thompson, C.B.7
Griesser, H.8
Mak, T.W.9
-
17
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role for CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role for CTLA-4. Immunity. 3:1995;541-546.
-
(1995)
Immunity
, vol.3
, pp. 541-546
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
18
-
-
0030740248
-
Thymocyte development is normal in CTLA-4-deficient mice
-
of special interest. The report demonstrates for the first time that thymocyte development is normal in mice deficient in cytotoxic T lymphocyte antigen 4 (CTLA-4) and the previous conclusion from other analyses were in fact derived using the phenotype of parathymic lymph nodes.
-
Chambers CA, Cado D, Truong T, Allison JP. Thymocyte development is normal in CTLA-4-deficient mice. of special interest Proc Natl Acad Sci USA. 94:1997;9296-9301 The report demonstrates for the first time that thymocyte development is normal in mice deficient in cytotoxic T lymphocyte antigen 4 (CTLA-4) and the previous conclusion from other analyses were in fact derived using the phenotype of parathymic lymph nodes.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9296-9301
-
-
Chambers, C.A.1
Cado, D.2
Truong, T.3
Allison, J.P.4
-
19
-
-
0030740572
-
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4 deficient mice
-
Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4 deficient mice. Eur J Immunol. 27:1997;1887-1892.
-
(1997)
Eur J Immunol
, vol.27
, pp. 1887-1892
-
-
Waterhouse, P.1
Bachmann, M.F.2
Penninger, J.M.3
Ohashi, P.S.4
Mak, T.W.5
-
22
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med. 183:1996;2533-2540.
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
23
-
-
0030966217
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
-
of special interest. This paper proposes for the first time that anergy is not induced in the absence of CD28-mediated co-stimulation signals, but is induced by the negative signal through the cytotoxic T lymphocyte antigen 4 (CTLA-4).
-
Perez V, Parjs LV, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. of special interest Immunity. 6:1997;411-417 This paper proposes for the first time that anergy is not induced in the absence of CD28-mediated co-stimulation signals, but is induced by the negative signal through the cytotoxic T lymphocyte antigen 4 (CTLA-4).
-
(1997)
Immunity
, vol.6
, pp. 411-417
-
-
Perez, V.1
Parjs, L.V.2
Biuckians, A.3
Zheng, X.X.4
Strom, T.B.5
Abbas, A.K.6
-
24
-
-
0028852073
-
Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86; Contains an intracellular localization motif in its cytoplasmic tail
-
Leung HT, Bradshaw J, Cleveland JS, Linsley PS. Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86; contains an intracellular localization motif in its cytoplasmic tail. J Biol Chem. 270:1995;25107-25114.
-
(1995)
J Biol Chem
, vol.270
, pp. 25107-25114
-
-
Leung, H.T.1
Bradshaw, J.2
Cleveland, J.S.3
Linsley, P.S.4
-
25
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin associated adaptor complex AP-2
-
of outstanding interest. of special interest. Both this study and those of Chang et al., 1997 [26] and Zhang and Allison, 1997 [27] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2, which induces rapid internalization of CTLA-4 from the cell surface. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2 and phosphorylation of the tyrosine inhibits the association. These results imply that CTLA-4 is rapidly endocytosed by association with AP-2, and upon phosphorylation CTLA-4 remained on the cell surface and could thus take part in signal transduction.
-
of outstanding interest Shiratori T, Miyatake S, Ohno H, Nakaseko C, Isono K, Bonifacino JS, Saito T. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin associated adaptor complex AP-2. of special interest Immunity. 6:1997;583-589 Both this study and those of Chang et al., 1997 [26] and Zhang and Allison, 1997 [27] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2, which induces rapid internalization of CTLA-4 from the cell surface. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2 and phosphorylation of the tyrosine inhibits the association. These results imply that CTLA-4 is rapidly endocytosed by association with AP-2, and upon phosphorylation CTLA-4 remained on the cell surface and could thus take part in signal transduction.
-
(1997)
Immunity
, vol.6
, pp. 583-589
-
-
Shiratori, T.1
Miyatake, S.2
Ohno, H.3
Nakaseko, C.4
Isono, K.5
Bonifacino, J.S.6
Saito, T.7
-
26
-
-
0031181647
-
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
-
of special interest. of outstanding interest. Both this study and those of Shiratori et al., 1997 [25] and Zhang and Allison, 1997 [27] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2.
-
of special interest Chang E, Alegre M-L, Duckett CS, Noel PJ, Van der Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. of outstanding interest J Immunol. 159:1997;144-151 Both this study and those of Shiratori et al., 1997 [25] and Zhang and Allison, 1997 [27] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2.
-
(1997)
J Immunol
, vol.159
, pp. 144-151
-
-
Chang, E.1
Alegre M-L2
Duckett, C.S.3
Noel, P.J.4
Van Der Heiden, M.G.5
Thompson, C.B.6
-
27
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
of special interest. of special interest. Both this study and those of Shiratori et al., 1997 [25] and Chang et al., 1997 [26] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2. Zhang and Allison also show the specific association of the phosphorylated tyrosine motif of CTLA-4 with the phosphatase SHP-2.
-
of special interest Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. of special interest Proc Natl Acad Sci USA. 94:1997;9273-9278 Both this study and those of Shiratori et al., 1997 [25] and Chang et al., 1997 [26] showed the association of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the adaptor complex AP-2. A tyrosine motif in the cytoplasmic tail of CTLA-4 binds to AP-2. Zhang and Allison also show the specific association of the phosphorylated tyrosine motif of CTLA-4 with the phosphatase SHP-2.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
-
28
-
-
0028840355
-
Interaction of tyrosine-based sorting signals with clathrin-associated protein
-
Ohno H, Stewart J, Fournier M-C, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS. Interaction of tyrosine-based sorting signals with clathrin-associated protein. Science. 269:1995;1872-1875.
-
(1995)
Science
, vol.269
, pp. 1872-1875
-
-
Ohno, H.1
Stewart, J.2
Fournier M-C3
Bosshart, H.4
Rhee, I.5
Miyatake, S.6
Saito, T.7
Gallusser, A.8
Kirchhausen, T.9
Bonifacino, J.S.10
-
29
-
-
0030794182
-
Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
-
Kirchhausen T, Bonifacino JS, Riezman H. Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol. 9:1997;488-495.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 488-495
-
-
Kirchhausen, T.1
Bonifacino, J.S.2
Riezman, H.3
-
30
-
-
0030003317
-
Protein targeting by tyrosine-and di-leucine-based signals: Evidence for distinct saturable components
-
Marks MS, Woodruff L, Ohno H, Bonifacino JS. Protein targeting by tyrosine-and di-leucine-based signals: evidence for distinct saturable components. J Cell Biol. 135:1996;341-354.
-
(1996)
J Cell Biol
, vol.135
, pp. 341-354
-
-
Marks, M.S.1
Woodruff, L.2
Ohno, H.3
Bonifacino, J.S.4
-
31
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
of outstanding interest. This report demonstrates for the first time that various TCR-signaling molecules such as Lck, ZAP-70 and CD3ζ are hyperphosphorylated in T cells from mice deficient in the cytotoxic T lymphocyte antigen 4 (CTLA-4), and that SHP-2 associates with the tyrosine motif in the cytoplasmic tail of CTLA-4. This association appears to mediate suppression of Ras-activation pathway.
-
Marengere LEM, Waterhouse P, Duncan GS, Mittrucker H-W, Feng G-S, Mak TW. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. of outstanding interest Science. 272:1996;1170-1173 This report demonstrates for the first time that various TCR-signaling molecules such as Lck, ZAP-70 and CD3ζ are hyperphosphorylated in T cells from mice deficient in the cytotoxic T lymphocyte antigen 4 (CTLA-4), and that SHP-2 associates with the tyrosine motif in the cytoplasmic tail of CTLA-4. This association appears to mediate suppression of Ras-activation pathway.
-
(1996)
Science
, vol.272
, pp. 1170-1173
-
-
Marengere, L.E.M.1
Waterhouse, P.2
Duncan, G.S.3
Mittrucker H-W4
Feng G-S5
Mak, T.W.6
-
32
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
of outstanding interest. The manuscript shows for the first time that the cytotoxic T lymphocyte antigen 4 (CTLA-4) is transported from the intracellular pool to the site of TCR engagement and that endocytosis occurs rapidly and independently of the traffic to the membrane.
-
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. of outstanding interest Immunity. 4:1996;535-543 The manuscript shows for the first time that the cytotoxic T lymphocyte antigen 4 (CTLA-4) is transported from the intracellular pool to the site of TCR engagement and that endocytosis occurs rapidly and independently of the traffic to the membrane.
-
(1996)
Immunity
, vol.4
, pp. 535-543
-
-
Linsley, P.S.1
Bradshaw, J.2
Greene, J.3
Peach, R.4
Bennett, K.L.5
Mittler, R.S.6
-
33
-
-
0030443168
-
Regulation of surface and intracellular expression of CTLA-4 on mouse T cells
-
Alegre M-L, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, Thompson CB. Regulation of surface and intracellular expression of CTLA-4 on mouse T cells. J Immunol. 157:1996;4762-4770.
-
(1996)
J Immunol
, vol.157
, pp. 4762-4770
-
-
Alegre M-L1
Noel, P.J.2
Eisfelder, B.J.3
Chuang, E.4
Clark, M.R.5
Reiner, S.L.6
Thompson, C.B.7
-
34
-
-
0028910221
-
CTLA-4 binding to the lipid kinase phosphatidylinosital 3-kinase in T cells
-
Schneider H, Prasad KVS, Shoelson SE, Rudd CE. CTLA-4 binding to the lipid kinase phosphatidylinosital 3-kinase in T cells. J Exp Med. 181:1995;351-355.
-
(1995)
J Exp Med
, vol.181
, pp. 351-355
-
-
Schneider, H.1
Prasad, K.V.S.2
Shoelson, S.E.3
Rudd, C.E.4
-
35
-
-
0030707866
-
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor and ZAP70
-
of special interest. This report shows for the first time that crosslinking of CTLA-4 suppresses the function of ERK and JNK but does not affect more TCR-proximal activation such as phosphorylation of CD3ζ and ZAP-70.
-
Calvo CR, Amsen D, Kruisbeek AM. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor and ZAP70. of special interest J Exp Med. 186:1997;1645-1653 This report shows for the first time that crosslinking of CTLA-4 suppresses the function of ERK and JNK but does not affect more TCR-proximal activation such as phosphorylation of CD3ζ and ZAP-70.
-
(1997)
J Exp Med
, vol.186
, pp. 1645-1653
-
-
Calvo, C.R.1
Amsen, D.2
Kruisbeek, A.M.3
-
38
-
-
0030812812
-
Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
-
of special interest. The authors show for the first time that anergic T cells possess activated Fyn associated with Cbl-CrkL, and this complex activates Rap-1. Active Rap-1 inhibits T cell activation. In addition, Raf-1 binds to Rap-1 rather than to Ras in anergic cells. Collectively, the Fyn - Cbl - CrkL - Rap-1 pathway may induce anergin in T cells, whereas T cells are activated through the Lck-ZAP70 pathway.
-
Boussiotis VA, Freeman G, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. of special interest Science. 278:1997;124-128 The authors show for the first time that anergic T cells possess activated Fyn associated with Cbl-CrkL, and this complex activates Rap-1. Active Rap-1 inhibits T cell activation. In addition, Raf-1 binds to Rap-1 rather than to Ras in anergic cells. Collectively, the Fyn - Cbl - CrkL - Rap-1 pathway may induce anergin in T cells, whereas T cells are activated through the Lck-ZAP70 pathway.
-
(1997)
Science
, vol.278
, pp. 124-128
-
-
Boussiotis, V.A.1
Freeman, G.2
Berezovskaya, A.3
Barber, D.L.4
Nadler, L.M.5
-
39
-
-
0029015726
-
Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- And intracellular domains
-
Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO. Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2:1995;439-449.
-
(1995)
Immunity
, vol.2
, pp. 439-449
-
-
Wagtmann, N.1
Biassoni, R.2
Cantoni, C.3
Verdiani, S.4
Malnati, M.S.5
Vitale, M.6
Bottino, C.7
Moretta, L.8
Moretta, A.9
Long, E.O.10
-
40
-
-
0029119219
-
Molecular cloning of NKB1: A natural killer cell receptor for HLA-B allotypes
-
D'Andrea A, Chang C, Franz-Bacon K, McClanahan T, Phillips JH, Lanier LL. Molecular cloning of NKB1: a natural killer cell receptor for HLA-B allotypes. J Immunol. 155:1995;2306-2310.
-
(1995)
J Immunol
, vol.155
, pp. 2306-2310
-
-
D'Andrea, A.1
Chang, C.2
Franz-Bacon, K.3
McClanahan, T.4
Phillips, J.H.5
Lanier, L.L.6
-
41
-
-
0029003984
-
Cloning of Ig-superfamily members associated with HLA-C and HLA-B recognition by human NK cells
-
Colonna M, Samaridis J. Cloning of Ig-superfamily members associated with HLA-C and HLA-B recognition by human NK cells. Science. 268:1995;405-408.
-
(1995)
Science
, vol.268
, pp. 405-408
-
-
Colonna, M.1
Samaridis, J.2
-
42
-
-
0030470555
-
Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits
-
Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J Immunol. 157:1996;4541-4745.
-
(1996)
J Immunol
, vol.157
, pp. 4541-4745
-
-
Lazetic, S.1
Chang, C.2
Houchins, J.P.3
Lanier, L.L.4
Phillips, J.H.5
-
43
-
-
0031053033
-
The CD94 and NKG-2-A C-type lectins covalently assemble to form a NK cell inhibitory receptor for HLA class I molecules
-
Carretero M, Cantoni C, Bellón T, Bottino C, Biassoni R, Rodriguez A, Pérez-Villar JJ, Moretta L, Moretta A, López-Botet M. The CD94 and NKG-2-A C-type lectins covalently assemble to form a NK cell inhibitory receptor for HLA class I molecules. Eur J Immunol. 27:1997;563-567.
-
(1997)
Eur J Immunol
, vol.27
, pp. 563-567
-
-
Carretero, M.1
Cantoni, C.2
Bellón, T.3
Bottino, C.4
Biassoni, R.5
Rodriguez, A.6
Pérez-Villar, J.J.7
Moretta, L.8
Moretta, A.9
López-Botet, M.10
-
44
-
-
0027933410
-
T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function
-
Ferrini S, Cambiaggi A, Meazza R, Sforzini S, Marciano S, Mingari MC, Moretta L. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol. 24:1994;2294-2298.
-
(1994)
Eur J Immunol
, vol.24
, pp. 2294-2298
-
-
Ferrini, S.1
Cambiaggi, A.2
Meazza, R.3
Sforzini, S.4
Marciano, S.5
Mingari, M.C.6
Moretta, L.7
-
45
-
-
0028950749
-
Cytotoxic T lymphocytes displaying natural killer (NK)-like activity: Expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis of lymphokine production
-
Mingari MC, Vitale C, Cambiagi A, Schiavetti F, Melioli G, Ferrini S, Doggi A. Cytotoxic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis of lymphokine production. Int Immunol. 7:1995;697-703.
-
(1995)
Int Immunol
, vol.7
, pp. 697-703
-
-
Mingari, M.C.1
Vitale, C.2
Cambiagi, A.3
Schiavetti, F.4
Melioli, G.5
Ferrini, S.6
Doggi, A.7
-
46
-
-
0029038380
-
Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes
-
Phillips JH, Grunperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science. 268:1995;403-405.
-
(1995)
Science
, vol.268
, pp. 403-405
-
-
Phillips, J.H.1
Grunperz, J.E.2
Parham, P.3
Lanier, L.L.4
-
47
-
-
2642611958
-
Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: Association of NKR2A with SHP-1 and SHP-2 protein-tyrosine phosphatases
-
Dréan EL, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Joterean F, Vivier E. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKR2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur J Immunol. 28:1998;264-276.
-
(1998)
Eur J Immunol
, vol.28
, pp. 264-276
-
-
Dréan, E.L.1
Vély, F.2
Olcese, L.3
Cambiaggi, A.4
Guia, S.5
Krystal, G.6
Gervois, N.7
Moretta, A.8
Joterean, F.9
Vivier, E.10
-
48
-
-
0028827365
-
Inhibition of γδ T cell recognition by receptors for MHC class I molecules
-
Nakajima H, Tomiyama H, Takiguchi M. Inhibition of γδ T cell recognition by receptors for MHC class I molecules. J Immunol. 155:1995;4139-4142.
-
(1995)
J Immunol
, vol.155
, pp. 4139-4142
-
-
Nakajima, H.1
Tomiyama, H.2
Takiguchi, M.3
-
49
-
-
0030962059
-
Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor
-
Ikeda H, Lethé B, Lehmann F, Baren NV, Banrain J-F, DeSmet C, Chambost H, Vitale M, Moretta A, Boon T, Coulie PG. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity. 6:1997;199-208.
-
(1997)
Immunity
, vol.6
, pp. 199-208
-
-
Ikeda, H.1
Lethé, B.2
Lehmann, F.3
Baren, N.V.4
Banrain J-F5
Desmet, C.6
Chambost, H.7
Vitale, M.8
Moretta, A.9
Boon, T.10
Coulie, P.G.11
-
50
-
-
0029834981
-
Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles
-
D'Andrea A, Chang C, Phillips JH, Lanier LL. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J Exp Med. 184:1996;789-794.
-
(1996)
J Exp Med
, vol.184
, pp. 789-794
-
-
D'Andrea, A.1
Chang, C.2
Phillips, J.H.3
Lanier, L.L.4
-
51
-
-
0031172446
-
Immunoreceptor tyrosine-based inhibition motifs
-
Vivier E, Daeron M. Immunoreceptor tyrosine-based inhibition motifs. Immunol Today. 18:1997;286-291.
-
(1997)
Immunol Today
, vol.18
, pp. 286-291
-
-
Vivier, E.1
Daeron, M.2
-
52
-
-
0030024788
-
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor
-
of outstanding interest. of special interest. In this report the association of phosphorylated immunoreceptor tyrosine-based inhibitory motifs of KIR with SHP-1 was found for the first time to be the inhibitory mechanism of the KIR-mediated inhibitory effect in NK cells. As also stated by Fry et al., 1996 [53], such phosphorylation of ITIM is crucial for both SHP-1 association and negative signaling.
-
of outstanding interest Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J-P, Long EO. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. of special interest Immunity. 4:1996;77-85 In this report the association of phosphorylated immunoreceptor tyrosine-based inhibitory motifs of KIR with SHP-1 was found for the first time to be the inhibitory mechanism of the KIR-mediated inhibitory effect in NK cells. As also stated by Fry et al., 1996 [53], such phosphorylation of ITIM is crucial for both SHP-1 association and negative signaling.
-
(1996)
Immunity
, vol.4
, pp. 77-85
-
-
Burshtyn, D.N.1
Scharenberg, A.M.2
Wagtmann, N.3
Rajagopalan, S.4
Berrada, K.5
Yi, T.6
Kinet J-P7
Long, E.O.8
-
53
-
-
0030037132
-
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C
-
of special interest. This reports the importance of the phosphorylation of the immunoreceptor tyrosine-based inhibitory motifs of the killer cell inhibitory receptors (KIRs) of natural killer cells for both association with the phosphatase SHP-1 and negative signaling by the KIRs.
-
Fry AM, Lanier LL, Weiss A. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. of special interest J Exp Med. 184:1996;295-300 This reports the importance of the phosphorylation of the immunoreceptor tyrosine-based inhibitory motifs of the killer cell inhibitory receptors (KIRs) of natural killer cells for both association with the phosphatase SHP-1 and negative signaling by the KIRs.
-
(1996)
J Exp Med
, vol.184
, pp. 295-300
-
-
Fry, A.M.1
Lanier, L.L.2
Weiss, A.3
-
54
-
-
0343307005
-
Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
-
of special interest. This report shows for the first time that whereas the immunoreceptor tyrosine-based inhibitory motif (ITIM) of killer cell inhibitory receptors associates with SHP-1 to mediate negative signals, ITIM of FcγRIIB associates with SHIP but not with SHP-1 for delivering the negative effect. There are two distinct mediators/systems for delivery of negative signals.
-
Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. of special interest Cell. 90:1997;293-301 This report shows for the first time that whereas the immunoreceptor tyrosine-based inhibitory motif (ITIM) of killer cell inhibitory receptors associates with SHP-1 to mediate negative signals, ITIM of FcγRIIB associates with SHIP but not with SHP-1 for delivering the negative effect. There are two distinct mediators/systems for delivery of negative signals.
-
(1997)
Cell
, vol.90
, pp. 293-301
-
-
Ono, M.1
Okada, H.2
Bolland, S.3
Yanagi, S.4
Kurosaki, T.5
Ravetch, J.V.6
-
55
-
-
0024550698
-
Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells
-
Chambers WH, Vujanovic NL, DeLeo AB, Olszowy MW, Herberman RB, Hiserodt JC. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells. J Exp Med. 169:1989;1373-1389.
-
(1989)
J Exp Med
, vol.169
, pp. 1373-1389
-
-
Chambers, W.H.1
Vujanovic, N.L.2
Deleo, A.B.3
Olszowy, M.W.4
Herberman, R.B.5
Hiserodt, J.C.6
-
56
-
-
0025086302
-
NKR-P1, a signal transduction molecule on natural killer cells
-
Giorda R, Rudert WA, Vavassori C, Chambers WH, Hiserodt JC, Trucco M. NKR-P1, a signal transduction molecule on natural killer cells. Science. 249:1990;1298-1300.
-
(1990)
Science
, vol.249
, pp. 1298-1300
-
-
Giorda, R.1
Rudert, W.A.2
Vavassori, C.3
Chambers, W.H.4
Hiserodt, J.C.5
Trucco, M.6
-
57
-
-
0028037079
-
Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
-
Bezouska K, Yuen C, O'Brien J, Childs RA, Chai W, Lawson AM, Drbal K, Fiserova A, Pospisil M, Feizi T. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature. 372:1994;150-157.
-
(1994)
Nature
, vol.372
, pp. 150-157
-
-
Bezouska, K.1
Yuen, C.2
O'Brien, J.3
Childs, R.A.4
Chai, W.5
Lawson, A.M.6
Drbal, K.7
Fiserova, A.8
Pospisil, M.9
Feizi, T.10
-
58
-
-
0028927207
-
NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity
-
Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 181:1995;1911-1915.
-
(1995)
J Exp Med
, vol.181
, pp. 1911-1915
-
-
Ryan, J.C.1
Niemi, E.C.2
Nakamura, M.C.3
Seaman, W.E.4
-
60
-
-
0031283018
-
+ T cells
-
+ T cells. This implies that NK cells utilize molecules bearing the immunoreceptor tyrosine-based activation motif for activation, in contrast to the killer cell inhibitory receptors, which utilize immunoreceptor tyrosine-based inhibitory motifs.
-
+ T cells. This implies that NK cells utilize molecules bearing the immunoreceptor tyrosine-based activation motif for activation, in contrast to the killer cell inhibitory receptors, which utilize immunoreceptor tyrosine-based inhibitory motifs.
-
(1997)
J Exp Med
, vol.186
, pp. 1957-1963
-
-
Arase, N.1
Arase, H.2
Park, S.Y.3
Ohno, H.4
Ra, C.5
Saito, T.6
-
61
-
-
0032510146
-
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
-
of outstanding interest. This paper describes a new molecule (DAP12) which is specific for natural killer (NK) cells that possesses an immunoreceptor tyrosine-based activation motif within the cytoplasmic tail and that associates with NK receptors that recognize MHC class I. Crosslinking of the complex induces phosphorylation of it and activation of NK cells.
-
Lanier LL, Corliss BC, Wu J, Leong C, Phillips J. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. of outstanding interest Nature. 391:1998;703-707 This paper describes a new molecule (DAP12) which is specific for natural killer (NK) cells that possesses an immunoreceptor tyrosine-based activation motif within the cytoplasmic tail and that associates with NK receptors that recognize MHC class I. Crosslinking of the complex induces phosphorylation of it and activation of NK cells.
-
(1998)
Nature
, vol.391
, pp. 703-707
-
-
Lanier, L.L.1
Corliss, B.C.2
Wu, J.3
Leong, C.4
Phillips, J.5
-
62
-
-
0030457066
-
The Ly-49D receptor activates murine natural killer cells
-
Mason LH, Anderson SK, Yokoyama WM, Smith HRC, Winkler-Pickett R, Ortaldo JR. The Ly-49D receptor activates murine natural killer cells. J Exp Med. 184:1996;2119-2128.
-
(1996)
J Exp Med
, vol.184
, pp. 2119-2128
-
-
Mason, L.H.1
Anderson, S.K.2
Yokoyama, W.M.3
Smith, H.R.C.4
Winkler-Pickett, R.5
Ortaldo, J.R.6
-
63
-
-
0030809965
-
P46, a novel natural killer cell-specific surface molecule that mediates cell activation
-
Sivori S, Vitale M, Morelli L, Sanseverino L, Augugliaro R, Bottino C, Moretta L, Moretta A. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med. 186:1997;1129-1136.
-
(1997)
J Exp Med
, vol.186
, pp. 1129-1136
-
-
Sivori, S.1
Vitale, M.2
Morelli, L.3
Sanseverino, L.4
Augugliaro, R.5
Bottino, C.6
Moretta, L.7
Moretta, A.8
-
64
-
-
0020197844
-
Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex
-
Reinherz EL, Mener S, Fitzgerald KA, Hussey RE, Levine H, Schlossman SF. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell. 30:1982;735-743.
-
(1982)
Cell
, vol.30
, pp. 735-743
-
-
Reinherz, E.L.1
Mener, S.2
Fitzgerald, K.A.3
Hussey, R.E.4
Levine, H.5
Schlossman, S.F.6
-
65
-
-
0029037210
-
Serial triggering of many T-cell receptors by a few peptide-MHC complexes
-
Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature. 375:1995;148-151.
-
(1995)
Nature
, vol.375
, pp. 148-151
-
-
Valitutti, S.1
Muller, S.2
Cella, M.3
Padovan, E.4
Lanzavecchia, A.5
-
66
-
-
0031448209
-
Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation
-
D'Oro U, Vacchio MS, Weissman AM, Ashwell JD. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity. 7:1997;619-628.
-
(1997)
Immunity
, vol.7
, pp. 619-628
-
-
D'Oro, U.1
Vacchio, M.S.2
Weissman, A.M.3
Ashwell, J.D.4
-
67
-
-
0027056895
-
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
-
Mizoguchi H, O'Shea JJ, Long DL, Loeffler CM, Mcvicar DW, Ochoa AC. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science. 258:1992;1795-1798.
-
(1992)
Science
, vol.258
, pp. 1795-1798
-
-
Mizoguchi, H.1
O'Shea, J.J.2
Long, D.L.3
Loeffler, C.M.4
McVicar, D.W.5
Ochoa, A.C.6
-
68
-
-
0028965830
-
Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex
-
Ace T, Okamoto Y, Saito T. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med. 181:1995;1881-1886.
-
(1995)
J Exp Med
, vol.181
, pp. 1881-1886
-
-
Ace, T.1
Okamoto, Y.2
Saito, T.3
-
69
-
-
0027453988
-
Decreased expression of the signal transducing ζchains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma
-
Nakagomi H, Petersson M, Magnusson I, Juhlin C, Matsuda M, Mellstedt H, Tanpin J-L, Vivier E, Anderson P, Kiessling R. Decreased expression of the signal transducing ζchains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res. 53:1993;5610-5612.
-
(1993)
Cancer Res
, vol.53
, pp. 5610-5612
-
-
Nakagomi, H.1
Petersson, M.2
Magnusson, I.3
Juhlin, C.4
Matsuda, M.5
Mellstedt, H.6
Tanpin J-L7
Vivier, E.8
Anderson, P.9
Kiessling, R.10
-
70
-
-
0028584161
-
High frequency of cancer patients bearing abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes
-
Gunji Y, Hori S, Aoe T, Asano T, Ochiai T, Isono K, Saito T. High frequency of cancer patients bearing abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes. Jpn J Cancer Res. 85:1994;1189-1192.
-
(1994)
Jpn J Cancer Res
, vol.85
, pp. 1189-1192
-
-
Gunji, Y.1
Hori, S.2
Aoe, T.3
Asano, T.4
Ochiai, T.5
Isono, K.6
Saito, T.7
-
71
-
-
0029841427
-
Oxidative stress by tumor-derived macrophages suppresses the expression of CD3ζ chain of T-cell receptor complex and antigen-specific T cell responses
-
of outstanding interest. This study and that of Kono et al., 1996 [72] demonstrate that the loss of CD3ζ and subsequent suppression of T cell function in tumor-bearing status is induced by oxidative stress and the loss is blocked by reducing reagent amino-acetyl cystein.
-
Otsuji M, Kimura Y, Aoe T, Okamoto Y, Saito T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3ζ chain of T-cell receptor complex and antigen-specific T cell responses. of outstanding interest Proc Natl Acad Sci USA. 93:1996;13119-13124 This study and that of Kono et al., 1996 [72] demonstrate that the loss of CD3ζ and subsequent suppression of T cell function in tumor-bearing status is induced by oxidative stress and the loss is blocked by reducing reagent amino-acetyl cystein.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13119-13124
-
-
Otsuji, M.1
Kimura, Y.2
Aoe, T.3
Okamoto, Y.4
Saito, T.5
-
72
-
-
0030048536
-
Hydrogen peroxide secreted by tumor-derived macrophages down - modulates signal transducing molecules and inhibits tumor-specific T cell- And natural killer cell-mediated cytotoxicity
-
Kono K, Salazar-Onfray F, Petersson M, Hansson J, Maasuxxi G, Wasserman K, Nakazawa T, Anderson P, Kiessling R. Hydrogen peroxide secreted by tumor-derived macrophages down - modulates signal transducing molecules and inhibits tumor-specific T cell- and natural killer cell-mediated cytotoxicity. Eur J Immunol. 26:1996;1308-1313.
-
(1996)
Eur J Immunol
, vol.26
, pp. 1308-1313
-
-
Kono, K.1
Salazar-Onfray, F.2
Petersson, M.3
Hansson, J.4
Maasuxxi, G.5
Wasserman, K.6
Nakazawa, T.7
Anderson, P.8
Kiessling, R.9
-
73
-
-
0027378767
-
lok in T cells infiltrating human renal cell carcinoma
-
lok in T cells infiltrating human renal cell carcinoma. Cancer Res. 53:1993;5613-5616.
-
(1993)
Cancer Res
, vol.53
, pp. 5613-5616
-
-
Finke, J.H.1
Zea, A.H.2
Stanley, J.3
Longo, D.L.4
Mizoguchi, H.5
Tubbs, R.R.6
Wiltrout, R.H.7
O'Shea, J.J.8
Kudoh, S.9
Klein, E.10
-
74
-
-
0029155655
-
fyn, ZAP-70 and CD3ζ despite suppressed cytolytic activity
-
fyn, ZAP-70 and CD3ζ despite suppressed cytolytic activity. J Exp Med. 182:1995;1029-1036.
-
(1995)
J Exp Med
, vol.182
, pp. 1029-1036
-
-
Levey, D.L.1
Srivastava, P.K.2
-
75
-
-
10144250282
-
HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression
-
of special interest. The authors demonstrated that TCR-associated tyrosine kinases, Lck, Fyn and ZAP-70 were lost or inactivated in T cells from HIV patients. In particular, the conformation of Lck was altered by redox-regulation, and the addition of reducing reagents restored the functional Lck protein, suggesting that redox regulates the structure and function of TCR-associated signaling molecules.
-
Stefanová I, Saville MW, Peters C, Cleghorn FR, Schwartz D, Venzon DJ, Weinhold KJ, Jak N, Bartholomew C, Blattner WA, et al. HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression. of special interest J Clin Invest. 98:1996;1290-1297 The authors demonstrated that TCR-associated tyrosine kinases, Lck, Fyn and ZAP-70 were lost or inactivated in T cells from HIV patients. In particular, the conformation of Lck was altered by redox-regulation, and the addition of reducing reagents restored the functional Lck protein, suggesting that redox regulates the structure and function of TCR-associated signaling molecules.
-
(1996)
J Clin Invest
, vol.98
, pp. 1290-1297
-
-
Stefanová, I.1
Saville, M.W.2
Peters, C.3
Cleghorn, F.R.4
Schwartz, D.5
Venzon, D.J.6
Weinhold, K.J.7
Jak, N.8
Bartholomew, C.9
Blattner, W.A.10
-
76
-
-
0031441901
-
Antiproliferative action of interferon-α requires components of T-cell-receptor signaling
-
of outstanding interest. The authors demonstrate for the first time that IFN-α receptor transduces signals for growth inhibition in T cells by association with the TCR-signaling molecules CD45, Lck and ZAP70. Signals through this complex are independent of activation of signal transducers and activators of transcription (STATs).
-
Petricoin EF III, Ito S, Williams BL, Andet S, Stancato LF, Gamero A, Clouse K, Grimley P, Weiss A, Beeler J, et al. Antiproliferative action of interferon-α requires components of T-cell-receptor signaling. of outstanding interest Nature. 390:1997;629-632 The authors demonstrate for the first time that IFN-α receptor transduces signals for growth inhibition in T cells by association with the TCR-signaling molecules CD45, Lck and ZAP70. Signals through this complex are independent of activation of signal transducers and activators of transcription (STATs).
-
(1997)
Nature
, vol.390
, pp. 629-632
-
-
Petricoin E.F. III1
Ito, S.2
Williams, B.L.3
Andet, S.4
Stancato, L.F.5
Gamero, A.6
Clouse, K.7
Grimley, P.8
Weiss, A.9
Beeler, J.10
-
77
-
-
0030761599
-
Induction of interleukin-2 unresponsiveness and down-regulation of the JAK-STAT system upon activation through the T cell receptor
-
Miyatake S, Sakuma M, Saito. Induction of interleukin-2 unresponsiveness and down-regulation of the JAK-STAT system upon activation through the T cell receptor. Eur J Immunol. 27:1997;1816-1823.
-
(1997)
Eur J Immunol
, vol.27
, pp. 1816-1823
-
-
Miyatake, S.1
Sakuma, M.2
Saito3
-
78
-
-
0030772420
-
Functional cleavage of the common cytokine receptor γ chain (γc) by calpain
-
Noguchi M, Sarin A, Arnan MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ. Functional cleavage of the common cytokine receptor γ chain (γc) by calpain. Proc Natl Acad Sci USA. 94:1997;11534-11539.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11534-11539
-
-
Noguchi, M.1
Sarin, A.2
Arnan, M.J.3
Nakajima, H.4
Shores, E.W.5
Henkart, P.A.6
Leonard, W.J.7
-
79
-
-
0032472226
-
Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge
-
Majeti R, Bilwes AM, Noel JP, Hunter T, Weiss A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science. 279:1998;88-91.
-
(1998)
Science
, vol.279
, pp. 88-91
-
-
Majeti, R.1
Bilwes, A.M.2
Noel, J.P.3
Hunter, T.4
Weiss, A.5
|