Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "γ-secretase"

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7010-7018

  Ikeuchi, Takeshi ^a   Dolios, Georgia ^b   Kim, Seong Hun ^a   Wang, Rong ^b   Sisodia, Sangram S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL BONDS; IMMUNOLOGY; LASER APPLICATIONS; MASS SPECTROMETRY; MUTAGENESIS; POLYPEPTIDES; PRECIPITATION (CHEMICAL);

LASER DESORPTION;

BIOCHEMISTRY;

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE INHIBITOR; L 685458; MEMBRANE PROTEIN; MUTANT PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PEPTIDE DERIVATIVE; PRESENILIN 1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; ENZYME INHIBITOR; PEPTIDE; PEPTIDE FRAGMENT; PROTEINASE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; CATALYST; CHEMICAL BOND; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG POTENCY; DRUG SENSITIVITY; ENZYME ACTIVITY; IC 50; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN VARIANT; REGULATORY MECHANISM; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; HYDROLYSIS; IMMUNOBLOTTING; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS;

ANIMALIA;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; ENZYME INHIBITORS; HYDROLYSIS; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MEMBRANE PROTEINS; MICE; PEPTIDE FRAGMENTS; PEPTIDES; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR CELLS, CULTURED;

EID: 0037470192     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209252200     Document Type: Article

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