Rank-order of potencies for inhibition of the secretion of Aβ40 and Aβ42 suggests that both are generated by a single γ-secretase

Journal of Biological Chemistry

Volumn 274, Issue 29, 1999, Pages 20499-20504

  Durkin, John T ^a   Murthy, Seetha ^a   Husten, E Jean ^a   Trusko, Stephen P ^a   Savage, Mary J ^a   Rotella, David P ^a,b   Greenberg, Barry D ^a,c   Siman, Robert ^a,d  

^a CEPHALON INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ENZYME; GAMMA SECRETASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; HUMANS; PROTEASE INHIBITORS; TUMOR CELLS, CULTURED;

EID: 0033575224     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.29.20499     Document Type: Article

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