Requirement for Presenilin 1 in facilitating jagged 2-mediated endoproteolysis and signaling of notch 1

Journal of Molecular Neuroscience

Volumn 15, Issue 3, 2000, Pages 189-204

  Martys Zage, J L ^a   Kim, S H ^a   Berechid, B ^a   Bingham, S J ^a   Chu, S ^a   Sklar, J ^a   Nye, J ^a   Sisodia, S S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alzheimer's disease; Green fluorescent protein; Jagged 2; Notch 1; Presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELL SURFACE RECEPTOR; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; NOTCH RECEPTOR; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL SURFACE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CARBAMATES; CARRIER PROTEINS; CELL LINE, TRANSFORMED; CELL MEMBRANE; CELL NUCLEUS; DIPEPTIDES; ENDOPEPTIDASES; FETUS; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PRESENILIN-1; PROTEASE INHIBITORS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

ANIMALIA;

EID: 0034457993     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:15:3:189     Document Type: Article

References (37)

1. Notch signaling: Cell fate control and signal integration in development
2. Lack of requirement for presenilin1 in Notch1 signaling
3. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
4. Presenilins, processing of beta-amyloid precursor protein, and notch signaling
5. High-efficiency transformation of mammalian cells by plasmid DNA
6. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
7. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
8. Transition-state analogue inhibitors of-secretase bind directly to presenilin-1
9. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
10. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
11. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
12. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos
13. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
14. Presenilin 1 is linked with gamma -secretase activity in the deter-gent solubilized state
15. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
16. The Notch1 receptor is cleaved constitutively by a furin-like convertase
17. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
18. Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses
19. Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion
20. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
21. Effects of PS1 deficiency on membrane protein trafficking in neurons
22. Mutant genes in familial Alzheimer's disease and transgenic models
23. Calcium depletion dissociates and activates heterodimeric notch receptors
24. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
25. Nuclear Notch1 signaling and the regulation of dendritic development
26. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
27. Notch and presenilins in vertebrates and invertebrates: Implications for neuronal development and degeneration
28. Skeletal and CNS defects in Presenilin-1-deficient mice
29. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
30. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
31. Analysis of mutations in alleles of the fur gene from an endoprotease-deficient Chinese hamster ovary cell strain
32. Nuclear access and action of notch in vivo
33. Presenilin is required for activity and nuclear access of Notch in Drosophila
34. Metabolism of the "Swedish" amyloid precursor protein variant in Neuro2a (N2a) cells
35. A stopcodon mutation in the BRI gene associated with familial British dementia
36. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
37. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants