Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

Science

Volumn 277, Issue 5325, 1997, Pages 559-562

  Kostic, Vladimir ^a   Jackson Lewis, Vernice ^a   De Bilbao, Fabienne ^b   Dubois Dauphin, Michel ^b   Przedborski, Serge ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CASPASE; CHOLINE ACETYLTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE PROTEINASE; GLYCINE; PROTECTIVE AGENT; PROTEIN BCL 2; UBIQUITIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; MYELINATED NERVE; NERVE ENDING; NEWBORN; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; SURVIVAL; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE THERAPY; GENES, BCL-2; HUMANS; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NERVE DEGENERATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-JUN; SPINAL CORD; SUPEROXIDE DISMUTASE; SURVIVAL RATE; UBIQUITINS;

ANIMALIA; MUS MUSCULUS;

EID: 0030756459     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5325.559     Document Type: Article

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51. We thank A. B. Naini and R. Yokoyama for performing the SOD assays, M. Schoenebeck for preparing phrenic nerve sections, M. Gurney for kindly providing the information about the number of copies in the transgenic G93A mice and the G1H mice, and R. E. Burke and C. M. Troy for their insightful comments on the manuscript. This work was supported by the Muscular Dystrophy Association, the National Institute of Neurological Disorders and Stroke (grant NS01724), the Swiss National Foundation (grant 31-4331695), the Lowenstein Foundation, and the Parkinson's Disease Foundation. S.P. is a recipient of the Irving A. Hansen Memorial Foundation Award and the Cotzias Award from the American Parkinson Disease Association.