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Volumn 3, Issue 3, 2003, Pages 199-210

Regulatory T cells in transplantation tolerance

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CALCINEURIN INHIBITOR; CALCITRIOL; CD4 ANTIGEN; CYCLOSPORIN; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY CD3;

EID: 0037364976     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1027     Document Type: Review
Times cited : (1207)

References (138)
  • 1
    • 0142250482 scopus 로고    scopus 로고
    • Regulatory T cells under scrutiny
    • Bach, J-F. Regulatory T cells under scrutiny. Nature Rev. Immunol. 3, 189-198 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 189-198
    • Bach, J.-F.1
  • 2
    • 0035967487 scopus 로고    scopus 로고
    • The role of peripheral T-cell deletion in transplantation tolerance
    • Wells, A., Li, X., Strom, T. & Turka, L. The role of peripheral T-cell deletion in transplantation tolerance. Phil. Trans. R. Soc. Lond. B 356, 617-623 (2001).
    • (2001) Phil. Trans. R. Soc. Lond. B , vol.356 , pp. 617-623
    • Wells, A.1    Li, X.2    Strom, T.3    Turka, L.4
  • 4
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon, R. & Kondo, K. Infectious immunological tolerance. Immunology 21, 903-914 (1971).
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.1    Kondo, K.2
  • 5
    • 0016812372 scopus 로고
    • Suppressor T cells in mice made unresponsive to skin allografts
    • Kishaw, P., Brent, L. & Pinto, M. Suppressor T cells in mice made unresponsive to skin allografts. Nature 255, 489-491 (1975).
    • (1975) Nature , vol.255 , pp. 489-491
    • Kishaw, P.1    Brent, L.2    Pinto, M.3
  • 6
    • 0022448187 scopus 로고
    • Suppressor T cells in allogeneic models
    • Hutchinson, I. V. Suppressor T cells in allogeneic models. Transplantation 41, 547-555 (1986).
    • (1986) Transplantation , vol.41 , pp. 547-555
    • Hutchinson, I.V.1
  • 7
    • 0037128654 scopus 로고    scopus 로고
    • Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    • Gilliet, M. & Liu, Y.-J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 195, 695-704 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 695-704
    • Gilliet, M.1    Liu, Y.-J.2
  • 9
    • 0032533472 scopus 로고    scopus 로고
    • + CD28-regulatory T cells
    • + CD28-regulatory T cells. J. Immunol. 161, 5193-5202 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 5193-5202
    • Ciubotariu, R.1
  • 10
    • 0033929005 scopus 로고    scopus 로고
    • Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    • Zhang, Z., Yang, L., Young, K., DuTemple, B. & Zhang, L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nature Med. 6, 782-789 (2000).
    • (2000) Nature Med. , vol.6 , pp. 782-789
    • Zhang, Z.1    Yang, L.2    Young, K.3    DuTemple, B.4    Zhang, L.5
  • 11
    • 0142171511 scopus 로고    scopus 로고
    • + T cells reciprocally regulate acute graft-versus-host disease
    • + T cells reciprocally regulate acute graft-versus-host disease. Blood 99, 1449-1457 (1999).
    • (1999) Blood , vol.99 , pp. 1449-1457
    • Zeng, D.1
  • 12
    • 0035956942 scopus 로고    scopus 로고
    • Requirement for natural killer T (NKT cells in the induction of allograft tolerance
    • Seino, K.-I. et al. Requirement for natural killer T (NKT cells in the induction of allograft tolerance. Proc. Natl Acad. Sci. USA 98, 2577-2581 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2577-2581
    • Seino, K.-I.1
  • 13
    • 0035806276 scopus 로고    scopus 로고
    • + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193, 1311-1318 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 1311-1318
    • Taylor, P.1    Noelle, R.J.2    Blazar, B.R.3
  • 14
    • 0037025943 scopus 로고    scopus 로고
    • + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196, 389-399 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 16
    • 0037097594 scopus 로고    scopus 로고
    • The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK-cell receptor
    • Chambers, C. A. et al. The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK-cell receptor. Blood 99, 4509-4516 (2002).
    • (2002) Blood , vol.99 , pp. 4509-4516
    • Chambers, C.A.1
  • 17
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Reg) cells have an important role in the maintenance of self-tolerance.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 18
    • 0035806289 scopus 로고    scopus 로고
    • + suppressor T cells
    • + suppressor T cells. J. Exp. Med. 193, F41-F45 (2001).
    • (2001) J. Exp. Med. , vol.193
    • Shevach, E.1
  • 20
    • 0035869432 scopus 로고    scopus 로고
    • IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    • Reg cells to maintain tolerance in vivo.
    • (2001) J. Immunol. , vol.166 , pp. 3789-3796
    • Hara, M.1
  • 21
    • 0036467522 scopus 로고    scopus 로고
    • + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168, 1080-1086 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 22
    • 0036498560 scopus 로고    scopus 로고
    • Tracking immunoregulatory mechanisms during allograft tolerance
    • Sanchez-Fueyo, A., Weber, M., Domenig, C., Strom, T. & Zheng, X. Tracking immunoregulatory mechanisms during allograft tolerance. J. Immunol. 168, 2274-2281 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 2274-2281
    • Sanchez-Fueyo, A.1    Weber, M.2    Domenig, C.3    Strom, T.4    Zheng, X.5
  • 23
    • 0036604283 scopus 로고    scopus 로고
    • - regulatory cells mediate dominant transplantation tolerance
    • - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168, 5558-5565 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5558-5565
    • Graca, L.1
  • 25
    • 0035806323 scopus 로고    scopus 로고
    • + T regulatory cells suppress naive and memory T-cell proliferation and can be expanded in vitro without loss of function
    • + T regulatory cells suppress naive and memory T-cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193, 1295-1301 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 1295-1301
    • Levings, M.1    Sangregono, R.2    Roncarolo, M.-G.3
  • 27
    • 0035525739 scopus 로고    scopus 로고
    • + cells: A naturally occurring population of regulatory T cells
    • + cells: a naturally occurring population of regulatory T cells Blood 98, 2735-2744 (2001).
    • (2001) Blood , vol.98 , pp. 2735-2744
    • Ng, W.F.1
  • 28
    • 0035054606 scopus 로고    scopus 로고
    • + thymocytes and peripheral T cells have immune suppressive activity in vitro
    • + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31, 1247-1254 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1247-1254
    • Stephens, L.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 29
    • 0035062581 scopus 로고    scopus 로고
    • + T cells: A highly differentiated and apoptosis-prone population
    • + T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31, 1122-1131 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1122-1131
    • Taams, L.1
  • 30
    • 0026658927 scopus 로고
    • Immune receptors: Targets for therapy of leukemia/lymphoma, autoimmune diseases and for the prevention of allograft rejection
    • Reg cells are present in humans.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 675-704
    • Waldmann, T.A.1
  • 31
    • 0035678962 scopus 로고    scopus 로고
    • Interleukin-2 receptor monoclonal antibodies in renal transplantation: Current use and emerging regimens
    • Vincenti, F. Interleukin-2 receptor monoclonal antibodies in renal transplantation: current use and emerging regimens Transplant. Proc. 33, 3169-3171 (2001).
    • (2001) Transplant. Proc. , vol.33 , pp. 3169-3171
    • Vincenti, F.1
  • 32
    • 0033853625 scopus 로고    scopus 로고
    • + T cells as a functionally and phenotypically distinct immunoregulatory T-cell subpopulation
    • + T cells as a functionally and phenotypically distinct immunoregulatory T-cell subpopulation. Int. Immunol. 12, 1145-1155 (2000).
    • (2000) Int. Immunol. , vol.12 , pp. 1145-1155
    • Kuniyasu, Y.1
  • 34
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new onset type 1 diabetes mellitus
    • Herold, K. et al. Anti-CD3 monoclonal antibody in new onset type 1 diabetes mellitus. N. Engl. J. Med. 346, 1740-1742 (2002). A clinical study showing that therapy with CD3-specific monoclonal antibodies has the potential to control the progression of diabetes.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1740-1742
    • Herold, K.1
  • 35
    • 0028176656 scopus 로고
    • Indirect presentation of MHC antigens in transplantation
    • Shoskes, D. & Wood, K. Indirect presentation of MHC antigens in transplantation. Immunol. Today 15, 1-7 (1994).
    • (1994) Immunol. Today , vol.15 , pp. 1-7
    • Shoskes, D.1    Wood, K.2
  • 36
    • 0020073022 scopus 로고
    • Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor-strain dendritic cells
    • Lechler, R. I. & Batchelor, J. R. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor-strain dendritic cells. J. Exp. Med. 155, 31-41 (1982).
    • (1982) J. Exp. Med. , vol.155 , pp. 31-41
    • Lechler, R.I.1    Batchelor, J.R.2
  • 37
    • 0027538467 scopus 로고
    • The role of 'indirect' recognition in initiating rejection of skin grafts from major histocompatibility complex class-II-deficient mice
    • Auchincloss, H. et al. The role of 'indirect' recognition in initiating rejection of skin grafts from major histocompatibility complex class-II-deficient mice. Proc. Natl. Acad. Sci. USA 90, 3373-3377 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3373-3377
    • Auchincloss, H.1
  • 38
    • 0032400989 scopus 로고    scopus 로고
    • Linked suppression of skin graft rejection can operate through indirect recognition
    • Wise, M. P., Bemelman, F., Cobbold, S. P. & Waldmann, H. Linked suppression of skin graft rejection can operate through indirect recognition. J. Immunol. 161, 5813-5816 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 5813-5816
    • Wise, M.P.1    Bemelman, F.2    Cobbold, S.P.3    Waldmann, H.4
  • 39
    • 0035889926 scopus 로고    scopus 로고
    • Cutting edge: Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade
    • Yamada, A. et al. Cutting edge: recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade. J. Immunol. 167, 5522-5526 (2001). An elegant demonstration that the indirect pathway of allorecognition is required for long-term allograft survival.
    • (2001) J. Immunol. , vol.167 , pp. 5522-5526
    • Yamada, A.1
  • 40
    • 0031032098 scopus 로고    scopus 로고
    • Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine
    • Blancho, G. et al. Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine. Transplantation 63, 26-33 (1997).
    • (1997) Transplantation , vol.63 , pp. 26-33
    • Blancho, G.1
  • 41
    • 0026770220 scopus 로고
    • Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat
    • Sayegh, M. H., Khoury, S., Hancock, W., Weiner, H. & Carpenter, C. Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat, Proc. Natl. Acad. Sci. USA 89, 7762-7766 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7762-7766
    • Sayegh, M.H.1    Khoury, S.2    Hancock, W.3    Weiner, H.4    Carpenter, C.5
  • 42
    • 0034722630 scopus 로고    scopus 로고
    • Non-depleting anti-CD4 antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts
    • Niimi, M. et al. Non-depleting anti-CD4 antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts. Transplantation 70, 1524-1548 (2000).
    • (2000) Transplantation , vol.70 , pp. 1524-1548
    • Niimi, M.1
  • 43
    • 0024417387 scopus 로고
    • Effect of one-HLA-DR antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts
    • Lagaaij, E. L. et al. Effect of one-HLA-DR antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts. N. Engl. J. Med. 321, 701-705 (1989).
    • (1989) N. Engl. J. Med. , vol.321 , pp. 701-705
    • Lagaaij, E.L.1
  • 44
    • 0027565191 scopus 로고
    • A molecular mechanism of T-cell downregulation by blood transfusion
    • Claas, F., de Koster, H. & van Rood, J. A molecular mechanism of T-cell downregulation by blood transfusion. Exp. Nephrol. 1, 134-138 (1993).
    • (1993) Exp. Nephrol. , vol.1 , pp. 134-138
    • Claas, F.1    De Koster, H.2    Van Rood, J.3
  • 45
    • 0035180065 scopus 로고    scopus 로고
    • + regulatory T cells: Their common role in controlling autoimmunity, tumour immunity and transplantation tolerance
    • + regulatory T cells: their common role in controlling autoimmunity, tumour immunity and transplantation tolerance. Immunol. Rev. 182, 18-32 (2001).
    • (2001) Immunol. Rev. , vol.182 , pp. 18-32
    • Sakaguchi, S.1
  • 46
    • 0037106250 scopus 로고    scopus 로고
    • Impact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway
    • van Maurik, A., Wood, K. J. & Jones, N. Impact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway. Transplantation 74, 740-743 (2002).
    • (2002) Transplantation , vol.74 , pp. 740-743
    • Van Maurik, A.1    Wood, K.J.2    Jones, N.3
  • 48
    • 0033379266 scopus 로고    scopus 로고
    • + T cells play a critical role in costimulation blockade-resistant allograft rejection
    • + T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104, 1715-1722 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1715-1722
    • Trambley, J.1
  • 49
    • 0034662277 scopus 로고    scopus 로고
    • + T cells can trigger allograft rejection
    • + T cells can trigger allograft rejection. J. Immunol. 165, 1111-1118 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1111-1118
    • Jones, N.1
  • 50
    • 0034720744 scopus 로고    scopus 로고
    • + T cells contribute to the development of transplant ateriosclerosis despite CD154 blockade
    • + T cells contribute to the development of transplant ateriosclerosis despite CD154 blockade. Transplantation 69, 2609-2612 (2000).
    • (2000) Transplantation , vol.69 , pp. 2609-2612
    • Ensminger, S.1
  • 51
    • 0037111521 scopus 로고    scopus 로고
    • + alloantigen-specific immunoregulatory cells that can prevent CD8-T-cell-mediated graft rejection: Implications for anti-CD154 immunotherapy
    • + alloantigen-specific immunoregulatory cells that can prevent CD8-T-cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169, 5401-5404 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 5401-5404
    • Van Maurik, A.1    Wood, K.J.2    Jones, N.3
  • 54
    • 0034077559 scopus 로고    scopus 로고
    • + regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells
    • + regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30, 1538-1543 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1538-1543
    • Cederbom, L.1    Hall, H.2    Ivars, F.3
  • 55
    • 0027479685 scopus 로고
    • 'Infectious' transplantation tolerance
    • Qin, S. et al. 'Infectious' transplantation tolerance. Science 259, 974-977 (1993).
    • (1993) Science , vol.259 , pp. 974-977
    • Qin, S.1
  • 56
    • 0037099719 scopus 로고    scopus 로고
    • + T helper cells
    • + T helper cells. J. Exp. Med. 196, 255-260 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 255-260
    • Jonuleit, H.1
  • 57
    • 0037099733 scopus 로고    scopus 로고
    • + regulatory, contact-dependent T cells induce interleukin-10-producing, contact-independent type 1-like regulatory T cells
    • + regulatory, contact-dependent T cells induce interleukin-10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196, 247-253 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 58
    • 0031568550 scopus 로고    scopus 로고
    • Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients
    • Onodera, K. et al. Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients. J. Immunol. 158, 1572-1581 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 1572-1581
    • Onodera, K.1
  • 59
    • 0023865253 scopus 로고
    • Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes
    • Madsen, J. C., Superina, R. A., Wood, K. J. & Morris, P. J. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 332, 161-164 (1988). Exposure to a single donor alloantigen is sufficient to induce specific unresponsiveness to a fully allogeneic graft, which provides evidence for linked unresponsiveness.
    • (1988) Nature , vol.332 , pp. 161-164
    • Madsen, J.C.1    Superina, R.A.2    Wood, K.J.3    Morris, P.J.4
  • 60
    • 0029954498 scopus 로고    scopus 로고
    • + T cells in the induction of tolerance to class I molecules
    • + T cells in the induction of tolerance to class I molecules. Transplantation 61, 1532-1538 (1996).
    • (1996) Transplantation , vol.61 , pp. 1532-1538
    • Saitovitch, D.1    Morris, P.2    Wood, K.3
  • 61
    • 0030922225 scopus 로고    scopus 로고
    • Pretransplant administration of a single donor class I MHC molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: Evidence for linked epitope suppression
    • Wong, W., Morris, P. & Wood, K. Pretransplant administration of a single donor class I MHC molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: evidence for linked epitope suppression. Transplantation 63, 1490-1494 (1997).
    • (1997) Transplantation , vol.63 , pp. 1490-1494
    • Wong, W.1    Morris, P.2    Wood, K.3
  • 62
    • 0029918208 scopus 로고    scopus 로고
    • T-cell suppression in transplantation tolerance through linked recognition
    • Davies, J. D., Leong, L. Y., Mellor, A., Cobbold, S. P. & Waldmann, H. T-cell suppression in transplantation tolerance through linked recognition. J. Immunol. 156, 3602-3607 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 3602-3607
    • Davies, J.D.1    Leong, L.Y.2    Mellor, A.3    Cobbold, S.P.4    Waldmann, H.5
  • 63
    • 0035160706 scopus 로고    scopus 로고
    • Tolerance to solid organ transplants through transfer of MHC class II genes
    • Sonrag, K.-C. et al. Tolerance to solid organ transplants through transfer of MHC class II genes. J. Clin. Invest. 107, 65-71 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 65-71
    • Sonrag, K.-C.1
  • 64
    • 0031647622 scopus 로고    scopus 로고
    • + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10, 1969-1980 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 1969-1980
    • Takahashi, T.1
  • 65
    • 0033985780 scopus 로고    scopus 로고
    • + immunoregulatory T cells is antigen nonspecific
    • + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183-190 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 183-190
    • Thornton, A.1    Shevach, E.M.2
  • 67
    • 0036467347 scopus 로고    scopus 로고
    • H gene transcripts
    • H2 gene transcripts. J. Immunol. 168, 1069-1079 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1069-1079
    • ZeleniKa, D.1
  • 68
    • 0035903307 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J. Exp. Med. 194, 847-854 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 847-854
    • Iellem, A.1
  • 69
    • 0037026003 scopus 로고    scopus 로고
    • + human thymocytes
    • + human thymocytes. J. Exp. Med. 196, 379-387 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 379-387
    • Annunziato, F.1
  • 71
    • 25944435502 scopus 로고    scopus 로고
    • Gene expression associated with tolerance and rejection - Expression kinetics in different transplant models
    • Sawitzki, B. et al. Gene expression associated with tolerance and rejection - expression kinetics in different transplant models. Transplantation. 74, S244 (2002).
    • (2002) Transplantation , vol.74
    • Sawitzki, B.1
  • 72
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason, D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19, 395-404 (1998).
    • (1998) Immunol. Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 73
    • 0033136302 scopus 로고    scopus 로고
    • + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self tolerance
    • Reg cells is another important contribution of the thymus to the maintenance of self-tolerance.
    • (1999) J. Immunol. , vol.162 , pp. 5317-5326
    • Itoh, M.1
  • 75
    • 0029835613 scopus 로고    scopus 로고
    • Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium
    • Mogdigliani, Y. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur. J. Immunol. 26, 1807-1815 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1807-1815
    • Mogdigliani, Y.1
  • 76
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nature Immunol. 3, 756-763 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 77
    • 0036086232 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Eur. J. Immunol. 32, 1621-1630 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1621-1630
    • Taams, L.1
  • 78
    • 0029763175 scopus 로고    scopus 로고
    • Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for the maintenance of tolerance to alloantigen in anti-CD4-treated recipients
    • Hamano, K., Rawsthorne, M, Bushell, A., Morris, P. & Wood, K. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for the maintenance of tolerance to alloantigen in anti-CD4-treated recipients. Transplantation 62, 856-860 (1996).
    • (1996) Transplantation , vol.62 , pp. 856-860
    • Hamano, K.1    Rawsthorne, M.2    Bushell, A.3    Morris, P.4    Wood, K.5
  • 80
    • 0032031409 scopus 로고    scopus 로고
    • IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T-cell costimulation pathways
    • Konieczny, B. et al. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T-cell costimulation pathways. J. Immunol. 160, 2059-2064 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 2059-2064
    • Konieczny, B.1
  • 81
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R α-chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik,M., de Moreas, M., Pontoux, C., Vasseur, F. & Penit, C. Regulatory CD4 T cells: expression of IL-2R α-chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10, 371-378 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 371-378
    • Papiernik, M.1    De Moreas, M.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 82
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen, P. et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381, 434-438 (1996).
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, P.1
  • 83
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanised monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk, A. et al, Treatment with humanised monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Med. 5, 686-693 (1999).
    • (1999) Nature Med. , vol.5 , pp. 686-693
    • Kirk, A.1
  • 85
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin-10 in the function of regulatory T cells which inhibit intestinal inflammation
    • Asseman, C., Mauze, S., Leach, M., Coffman, R. & Powne, F. An essential role for interleukin-10 in the function of regulatory T cells which inhibit intestinal inflammation. J. Exp. Med. 190, 995-1004 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.3    Coffman, R.4    Powne, F.5
  • 86
    • 0032436036 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-β in donor transfusion-induced allograft tolerance
    • Josien, R. et al. A critical role for transforming growth factor-β in donor transfusion-induced allograft tolerance. J. Clin. Invest. 102, 1920-1926 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 1920-1926
    • Josien, R.1
  • 87
    • 0034656113 scopus 로고    scopus 로고
    • Transforming growth factor-β and interleukin-10 subvert delayed-type hypersensitivity in cardiac allograft acceptor mice
    • Bickerstaff, A., VanBuskirk, A., Wakely, E. & Orosz, G. Transforming growth factor-β and interleukin-10 subvert delayed-type hypersensitivity in cardiac allograft acceptor mice. Transplantation 69, 1517-1520 (2000).
    • (2000) Transplantation , vol.69 , pp. 1517-1520
    • Bickerstaff, A.1    VanBuskirk, A.2    Wakely, E.3    Orosz, G.4
  • 89
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor-β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor-β. J. Exp. Med. 194, 629-644 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 90
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal activation by inhibiting interleukin-2 production
    • + immunoregulatory T cells suppress polyclonal activation by inhibiting interleukin-2 production. J. Exp. Med. 188, 287-296 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.1    Shevach, E.2
  • 91
    • 0037099613 scopus 로고    scopus 로고
    • + regulatory T cells can mediate suppressor function in the absence of transforming growth factor-β 1 production and responsiveness
    • + regulatory T cells can mediate suppressor function in the absence of transforming growth factor-β1 production and responsiveness. J. Exp. Med. 196, 237-246 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 237-246
    • Piccirillo, C.A.1
  • 92
    • 0035956905 scopus 로고    scopus 로고
    • Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T-cell activation
    • Sullivan, T. J. et al. Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T-cell activation. Proc. Natl. Acad. Sci. USA 98, 2587-2592 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2587-2592
    • Sullivan, T.J.1
  • 93
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T-cell activation
    • Walunas, T. et al. CTLA-4 can function as a negative regulator of T-cell activation. Immunity 1, 405-413 (1994).
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.1
  • 94
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouss, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988 (1995).
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouss, P.1
  • 95
    • 0034679560 scopus 로고    scopus 로고
    • + regulatory T cells constitutively expressing cytotoxic T-lymphocyte-associated antigen 4
    • + regulatory T cells constitutively expressing cytotoxic T-lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 96
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 97
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon, B. & Bluestone, J. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.2
  • 99
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune disease
    • + immunoregulatory T cells that control autoimmune disease. Immunity. 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 100
    • 0035425004 scopus 로고    scopus 로고
    • B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis
    • Liu, Z. et al. B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis. J. Immunol. 167, 1830-1838 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1830-1838
    • Liu, Z.1
  • 101
    • 0036195161 scopus 로고    scopus 로고
    • + immunoregulatory T cells: Gene expression anaysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • + immunoregulatory T cells: gene expression anaysis reveals a functional role for the glucocorticoid-induced TNF receptor Immunity 16, 311-323 (2002).
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1
  • 103
    • 0033857377 scopus 로고    scopus 로고
    • 'Anergic' T cells modulate the T-cell-activating capacity of antigen-presenting cells
    • Taams, L., Boot, E., van Eden, W. & Wauben, M. 'Anergic' T cells modulate the T-cell-activating capacity of antigen-presenting cells. J. Autoimmun. 14, 335-341 (2000).
    • (2000) J. Autoimmun. , vol.14 , pp. 335-341
    • Taams, L.1    Boot, E.2    Van Eden, W.3    Wauben, M.4
  • 104
    • 0036467410 scopus 로고    scopus 로고
    • + T cells can act as suppressor cells by affecting autologous dendritic-cell conditioning and survival
    • + T cells can act as suppressor cells by affecting autologous dendritic-cell conditioning and survival. J. Immunol. 188, 1060-1068 (2002).
    • (2002) J. Immunol. , vol.188 , pp. 1060-1068
    • Frasca, L.1    Scotta, C.2    Lombardi, G.3    Piccolella, E.4
  • 105
    • 0035881234 scopus 로고    scopus 로고
    • Regulatory T cells induced by 1α25-dihydroxyvitamin D 3 and mycophenolate mofetil treatment mediate transplantation tolerance
    • Gregon, S. et al. Regulatory T cells induced by 1α 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 167, 1945-1953 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1945-1953
    • Gregon, S.1
  • 106
    • 0142202600 scopus 로고    scopus 로고
    • Control of regulatory T-cell development by transcription factor FOXP3
    • in the press
    • Hon, S., Nomura, T. & Sakaguchi, S. Control of regulatory T-cell development by transcription factor FOXP3. Science (in the press).
    • Science
    • Hon, S.1    Nomura, T.2    Sakaguchi, S.3
  • 107
    • 0036233983 scopus 로고    scopus 로고
    • Transcription factors: Tantalizing times for T cells
    • Ho, I. & Glimcher, L. H. Transcription factors: tantalizing times for T cells. Cell 109, S109-S120 (2003).
    • (2003) Cell , vol.109
    • Ho, I.1    Glimcher, L.H.2
  • 108
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy enteropathy, X-linked (IPEX) syndrome
    • WiJdin, R., Smyk-Pearson, S. & Filipovich, H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy enteropathy, X-linked (IPEX) syndrome. J. Med. Genet. 39, 537-545 (2002).
    • (2002) J. Med. Genet. , vol.39 , pp. 537-545
    • WiJdin, R.1    Smyk-Pearson, S.2    Filipovich, H.3
  • 109
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow, M. E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genet. 27, 68-73 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 111
    • 0345476290 scopus 로고    scopus 로고
    • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    • Wells, A. et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nature Med. 5. 1303-1307 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1303-1307
    • Wells, A.1
  • 112
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li, Y. et al. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature Med. 5, 1298-1302 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1298-1302
    • Li, Y.1
  • 113
    • 0029557697 scopus 로고
    • Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative transplant study
    • Opelz, G. Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative transplant study. Transplantation 15, 1220-1224 (1995).
    • (1995) Transplantation , vol.15 , pp. 1220-1224
    • Opelz, G.1
  • 114
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative Campath 1H and low-dose cyclosporin monotherapy in renal allograft recipients
    • Caine, R. et al. Prope tolerance, perioperative Campath 1H and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 351, 1701-1702 (1998).
    • (1998) Lancet , vol.351 , pp. 1701-1702
    • Caine, R.1
  • 115
    • 0035881424 scopus 로고    scopus 로고
    • Weaning of immunosuppression in living donor liver transplant recipients
    • Takatsuki, M. et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 72, 449-454 (2001).
    • (2001) Transplantation , vol.72 , pp. 449-454
    • Takatsuki, M.1
  • 116
    • 0021634253 scopus 로고
    • Sparing of suppressor cells: A critical action of cyclosporine
    • Kupiec-Weglinski, J. W., Filho, M., Strom, T. & Tilney, N. Sparing of suppressor cells: a critical action of cyclosporine. Transplantation 38, 97-101 (1984).
    • (1984) Transplantation , vol.38 , pp. 97-101
    • Kupiec-Weglinski, J.W.1    Filho, M.2    Strom, T.3    Tilney, N.4
  • 117
    • 0036467337 scopus 로고    scopus 로고
    • The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts
    • Jones, T. R. et al. The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts. J. Immunol. 168, 1123-1130 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1123-1130
    • Jones, T.R.1
  • 119
    • 0037018104 scopus 로고    scopus 로고
    • H2-inducing cytokines
    • H2-inducing cytokines. J. Exp. Med. 195, 603-616 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 603-616
    • Barrat, F.J.1
  • 120
    • 0034891246 scopus 로고    scopus 로고
    • + regulatory T cells by the neuropeptide α-melanocyte stimulating hormone (α-MSH)
    • + regulatory T cells by the neuropeptide α-melanocyte stimulating hormone (α-MSH). Immunol. Cell Biol. 79, 358-367 (2001).
    • (2001) Immunol. Cell Biol. , vol.79 , pp. 358-367
    • Taylor, A.1    Namba, K.2
  • 121
    • 0037093217 scopus 로고    scopus 로고
    • + immune regulatory cells inhibits graft-versus-host disease lethality
    • + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99, 3493-3499 (2002).
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 123
    • 0028027043 scopus 로고
    • Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells
    • Scully, R., Qin, S., CobboJd, S. & Waldmann, H. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur. J. Immunol. 24, 2383-2392 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2383-2392
    • Scully, R.1    Qin, S.2    CobboJd, S.3    Waldmann, H.4
  • 124
    • 0025998664 scopus 로고
    • The effect of intrathymic injection of donor blood on the graft-versus-host reaction and cardiac allograft survival in the rat
    • Hamano, K., Fujikura, Y., Fukada, S., Esato, K & Fukumoto, T. The effect of intrathymic injection of donor blood on the graft-versus-host reaction and cardiac allograft survival in the rat. Immunol. Cell Biol. 69, 185-189 (1991).
    • (1991) Immunol. Cell Biol. , vol.69 , pp. 185-189
    • Hamano, K.1    Fujikura, Y.2    Fukada, S.3    Esato, K.4    Fukumoto, T.5
  • 125
    • 0029817245 scopus 로고    scopus 로고
    • Thymic dependence of loss of tolerance in mixed allogeneic bone-marrow chimeras after depletion of donor antigen
    • Khan, A., Tomita, Y & Sykes, M. Thymic dependence of loss of tolerance in mixed allogeneic bone-marrow chimeras after depletion of donor antigen. Transplantation 62, 380-387 (1996).
    • (1996) Transplantation , vol.62 , pp. 380-387
    • Khan, A.1    Tomita, Y.2    Sykes, M.3
  • 126
    • 0032528258 scopus 로고    scopus 로고
    • Intrathymic deletion of alloreactive T cells in mixed bone-marrow chimeras prepared with a nonmyeloablative conditioning regime
    • Manilay, J., Pearson, D., Sergio, J., Swenson, K. & Sykes, M. Intrathymic deletion of alloreactive T cells in mixed bone-marrow chimeras prepared with a nonmyeloablative conditioning regime. Transplantation 66, 96-102 (1998).
    • (1998) Transplantation , vol.66 , pp. 96-102
    • Manilay, J.1    Pearson, D.2    Sergio, J.3    Swenson, K.4    Sykes, M.5
  • 127
    • 0028237260 scopus 로고
    • Anergic T cells as suppressor cells in vitro
    • Lombardi, G., Sidhu, S., Batchelor, R. & Lechler, R. Anergic T cells as suppressor cells in vitro. Science 264, 1587-1589 (1994).
    • (1994) Science , vol.264 , pp. 1587-1589
    • Lombardi, G.1    Sidhu, S.2    Batchelor, R.3    Lechler, R.4
  • 128
    • 0030776194 scopus 로고    scopus 로고
    • High dose/activation-associated tolerance: A mechanism for allograft tolerance
    • Bishop, G., Sun, J., Sheil, A. & McCaughan, G. High dose/activation-associated tolerance: a mechanism for allograft tolerance. Transplantation 64, 1377-1382 (1997).
    • (1997) Transplantation , vol.64 , pp. 1377-1382
    • Bishop, G.1    Sun, J.2    Sheil, A.3    McCaughan, G.4
  • 132
    • 0033571454 scopus 로고    scopus 로고
    • low-density cells from untreated mice prevent acute allograft rejection
    • low-density cells from untreated mice prevent acute allograft rejection. J. Immunol. 163, 5353-5357 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 5353-5357
    • Davies, J.1
  • 133
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B-cell activation antigen B7
    • Linsley, P. S. et al. CTLA-4 is a second receptor for the B-cell activation antigen B7. J. Exp. Med. 174, 561-569 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 561-569
    • Linsley, P.S.1
  • 134
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T-cell responses to antigen
    • Linsley, P. S. & Ledbetter, J. A. The role of the CD28 receptor during T-cell responses to antigen. Annu. Rev. Immunol. 11, 191-212 (1993).
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 135
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Engen, J. & Allison, J. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16, 23-35 (2002).
    • (2002) Immunity , vol.16 , pp. 23-35
    • Engen, J.1    Allison, J.2
  • 136
    • 0030962132 scopus 로고    scopus 로고
    • A new member of the tumour-necrosis factor/nerve growth factor receptor family inhibits T-cell receptor-induced apoptosis
    • Nocentini, G. et al. A new member of the tumour-necrosis factor/nerve growth factor receptor family inhibits T-cell receptor-induced apoptosis. Proc. Natl Acad. Sci. USA 94, 6216-6221 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6216-6221
    • Nocentini, G.1


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