Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-Cd4 treated recipients

Transplantation

Volumn 62, Issue 6, 1996, Pages 856-860

  Hamano, Kimikazu ^a,b   Rawsthorne, Mary Anne ^a   Bushell, Andrew R ^a   Morris, Peter J ^a   Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; OKT 4;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VASCULARIZATION;

EID: 0029763175     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199609270-00026     Document Type: Article

References (28)

1. Pearson TC, Darby C, Bushell AR, West L, Morris, PJ, Wood KJ. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation 1993; 55: 361.
2. Homan W, Fabre J, Morris P. Nature of the unresponsiveness induced by cyclosporin A in rats bearing renal allografts. Transplantation 1979; 28: 439.
3. Madsen JC, Peugh WN, Wood KJ, Morris PJ. The effect of anti-L3T4 monoclonal antibody on first-set rejection of murine cardiac allografts. Transplantation 1987; 44: 849.
4. Shizuru JA, Seydel KB, Flavin TF, et al. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation 1990; 50: 366.
5. Isobe M, Yagita H, Okumura K, Ihara A. Specific acceptance of cardiac allografts after treatment with antibodies to ICAm-1 and LFA-1. Science 1992; 255: 1125.
6. Kortz EO, Sakamoto K, Suzuki T, Guzzetta PC, Chester CH, Lunney JK, Sachs DH. Mechanism of tolerance following class I-disparate renal allografts in miniature swine: cellular responses of tolerant animals. Transplantation 1990; 49: 1142.
7. Pearson TC, Hamano K, Morris PJ, Wood KJ. Anti-CD4 monoclonal antibody induced allograft survival is associated with a defect in IL-2 dependent T cell activation. Transplant Proc 1993; 25: 786.
8. Hutchinson IV. Suppressor T cells in allogeneic models. Transplantation 1986; 41: 547.
9. Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994; 24: 2383.
10. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M. Cell migration, chimerism and graft acceptance. Lancet 1992; 339: 1579.
11. Starzl T, Demetris A, Murase N, Thomson A, Trucco M, Ricordi C. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993; 14: 326.
12. Ilano AL, McConnell MV, Gurley KE, Spinelli A, Pearce NW, Hall, BM. Cellular basis of allograft rejection in vivo. J Immunol 1989; 143: 2828.
13. Chen Z, Cobbold S, Metcalfe S, Waldmann H. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. J Immunol 1992; 22: 805.
14. Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 1987; 17: 1159.
15. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non H-2 antigens in rejection. Transplantation 1973; 16: 343.
16. Chen Z. A technique of cervical heterotopic heart transplantation in mice. Transplantation 1991; 52: 1099.
17. Pearson TC, Darby CR, Wood KJ. Successful secondary heterotopic cardiac transplantation in the mouse. Transplantation 1992; 53: 701.
18. Superina RA, Peugh WN, Wood KJ, Morris PJ. Assessment of primarily vascularized cardiac allografts in mice. Transplantation 1985; 42: 226.
19. Larsen C, Morris P, Austyn J. Migration of dendritic leukocytes form cardiac allografts into host spleens: a novel pathway for initiation of rejection. J Exp Med 1990; 171: 307.
20. Dallman MJ, Porter ACG, Larsen CP, Morris PJ. Lymphokine production in allografts - analysis of RNA by northern blotting. Transplant Proc 1989; 21: 296.
21. Starzl T, Demerits A, Trucco M, et al. Systemic chimerism in human female recipients of male livers. Lancet 1992; 340: 876.
22. Starzl T, Demetris A, Trucco M, et al. Chimerism and donor specific non-reactivity 27 to 29 years after kidney allotransplantation. Transplantation 1993; 55: 1272.
23. Suberbielle C, Calliat-Zucman S, Legendre C. Peripheral microchimerism in long-term cadaveric kidney allograft recipients. Lancet 1994; 343: 1468.
24. Schlitt H, Hindrieser J, Hisanaga M. Patterns of donor-type microchimerism after heart transplantation. Lancet 1994; 343: 1469.
25. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-Lyt-2 monoclonal antibodies on murine cardiac allograft rejection. Transplantation Proc 1987; 19: 3991.
26. Ramsdell F. Fowlkes BJ. Maintainance of in vivo tolerance by persistence of antigen. Science 1992; 257: 1130.
27. Murase N, Starzl T, Tanabe M, et al. Variable chimerism graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown Norway rats. Transplantation 1995. 60: 158.
28. Schlitt H, Hundrieser J, Ringe B, Pichlmayer R., Donor-type microchimerism associated with graft rejection eight years after liver transplantation. N Engl J Med 1994; 330: 646.