Certified professionals: CD4+CD25+ suppressor T cells

Journal of Experimental Medicine

Volumn 193, Issue 11, 2001, Pages

  Shevach, E M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; CELL ISOLATION; CELL POPULATION; CYTOKINE PRODUCTION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION; THYMUS;

EID: 0035806289     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.11.f41     Document Type: Note

References (32)

1. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
2. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
3. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
4. + immunoregulatory T cells suppress polydonal T cell activation in vitro by inhibiting interleukin 2 production
5. low T cells: A population of T cells with immune regulatory activities in vitro
6. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
7. + immunoregulatory T cells is antigen nonspecific
8. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
9. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
10. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
11. - subpopulations
12. Regulatory T cells in autoimmunity
13. + regulatory T cells induced by an agonist self-peptide
14. + T cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
15. + T cells with regulatory properties from human blood
16. + T cells with regulatory properties isolated from peripheral blood
17. + thymocytes and peripheral T cells have immune suppressive activity
18. + T cells: A highly differentiated and apoptosisprone population
19. hi regulatory cells in human peripheral blood
20. + regulatory T cells constitutively expressing cytotoxic lymphocyte-associated antigen 4
21. + regulatory cells that control intestinal inflammation
22. low T cells
23. - thymocytes
24. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
25. + T cells
26. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
27. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
28. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
29. + T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody
30. + T cell subset inhibits antigen-specific T-cell responses and prevents colitis
31. + T cells that prevent spontaneous autoimmune encephalomyelitis
32. Anergic T cells inhibit the antigen-presenting function of dendritic cells