Tolerance to solid organ transplants through transfer of MHC class II genes

Journal of Clinical Investigation

Volumn 107, Issue 1, 2001, Pages 65-71

  Sonntag, Kai C ^a   Emery, David W ^b   Yasumoto, Akihiko ^c   Haller, Gary ^d   Germana, Sharon ^a   Sablinski, Tomasz ^e   Shimizu, Akira ^f   Yamada, Kazuhiko ^a   Shimada, Hideaki ^c   Arn, Scott ^a   Sachs, David H ^a   LeGuern, Christian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e NOVARTIS PHARMA AG   (Switzerland)

^f NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ARTICLE; GENE LOCUS; GENE TRANSFER; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SWINE;

EID: 0035160706     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11015     Document Type: Article

References (35)

1. Impact of new immunosuppressive agents on late graft outcome
2. Toxic effects of immunosuppressive drugs: Mechanisms and strategies for controlling them
3. Induction of specific tolerance to class I disparate renal allografts in miniature swine with cyclosporine
4. The significant effect of HLA-DRB1 matching on acute rejection in kidney transplants
5. Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity
6. Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer
7. MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome
8. Retrovirus-mediated transfer and expression of an allogeneic major histocompatibility complex class II DRB cDNA in swine bone marrow cultures
9. Successful induction of long-term specific tolerance to fully allogeneic renal allografts in miniature swine
10. Characterization of monoclonal antibodies directed against swine leukocytes
11. Preparation and characterization of monoclonal antibodies reactive with porcine PBL
12. The renal allograft biopsy
13. International standardization of criteria for histologic diagnosis of chronic rejection in renal allografts
14. Murine anti-swine T4 and T8 monoclonal antibodies: Distribution and effects on proliferative and cytotoxic T cells
15. Retrovirus-mediated transfer of MHC class II cDNA into swine bone marrow cells
16. Chimerism and central tolerance
17. Tolerance, danger, and the extended family
18. Balancing the immune system for tolerance: A case for regulatory CD4 cells
19. Evidence for a specific post-transcriptional mechanism controlling the expression of HLA-DQ, but not -DR and -DP, molecules
20. Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation
21. Polymorphic and monomorphic HLA-DR determinants on human hematopoietic progenitor cells
22. Selective expression of class-II MHC antigens during hemopoietic differentiation
23. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients
24. Maintenance of in vivo tolerance by persistence of antigen
25. Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection
26. Molecular identification of porcine interleukin-10: Regulation of expression in a kidney allograft model
27. "Infectious" transplantation tolerance
28. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice
29. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
30. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
31. Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells
32. Adoptive transfer of a Th2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse
33. Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients
34. A role for Th2 cytokines in the suppression of CD8+ T cell-mediated graft rejection
35. Anergic T cells act as suppressor cells in vitro and in vivo