Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells

Journal of Experimental Medicine

Volumn 194, Issue 6, 2001, Pages 847-853

  Iellem, A ^a   Mariani, M ^a   Lang, R ^a   Recalde, H ^a   Panina Bordignon, P ^a   Sinigaglia, F ^a   D'Ambrosio, D ^a  

^a ROCHE MILANO RICERCHE   (Italy)

Author keywords

Chemokines; Cytokines; Immunosuppression; Lymphocyte homing; Lymphocyte horning; T lymphocyte subsets

Indexed keywords

CD4 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR;

ARTICLE; CHEMOTAXIS; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHEMOKINES, CC; CHEMOKINES, CXC; CHEMOTAXIS; HUMANS; IMMUNOCONJUGATES; MACROPHAGE INFLAMMATORY PROTEINS; RECEPTORS, CHEMOKINE; RECEPTORS, INTERLEUKIN-2;

EID: 0035903307     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.6.847     Document Type: Article

References (30)

1. The biology of chemokines and their receptors
2. Chemokines: A new classification system and their role in immunity
3. Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
4. The role of chemokine receptors in primary, effector, and memory immune responses
5. Chemokines as regulators of T cell differentiation
6. Regulatory T cells and inflammatory bowel disease
7. Regulatory T cells: Key controllers of immunologic self-tolerance
8. Regulatory T cells in autoimmunity
9. + regulatory cells that control intestinal inflammation
10. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
11. + suppressor T cells
12. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
13. + inmmnoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
14. A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum
15. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
16. Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1
17. Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells
18. Inhibition by IL-12 and IFN-α of I-309 and macrophage-derived chemokine production upon TCR triggering of human Th1 cells
19. Visualizing T cell competition for peptide/MHC complexes: A specific mechanism to minimize the effect of precursor frequency
20. T cells compete for access to antigen-bearing antigen-presenting cells
21. Selective upregulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 T helper cells
22. Reversal of proinflammatory responses by ligating the macrophage Fcγ receptor type I
23. A novel polypetide secreted by activated human lymphocytes
24. Localization of Th-cell subsets in inflammation: Differential thresholds for extravasation of Th1 and Th2 cells
25. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
26. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential
27. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
28. The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8
29. The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant
30. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells