T cell suppression in transplantation tolerance through linked recognition

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3602-3607

  Davies, Joanna D ^a,c   Leong, Louise Y W ^a,d   Mellor, Andrew ^b,e   Cobbold, Stephen P ^a,f   Waldmann, Herman ^a,f  

^a Department of Pathology ^*  (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; GRAFT REJECTION; HISTOCOMPATIBILITY TEST; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD4; ANTIGENS, CD8; CROSSES, GENETIC; GRAFT REJECTION; H-2 ANTIGENS; IMMUNE TOLERANCE; MICE; MICE, INBRED AKR; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MINOR LYMPHOCYTE STIMULATORY ANTIGENS; SKIN TRANSPLANTATION; SPECIES SPECIFICITY; T-LYMPHOCYTE SUBSETS;

EID: 0029918208     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Paul, W. E., and R. A Seder 1994. Lymphocyte responses and cytokines. Cell 76:241.
2. Janeway, C. A., and K. Bottomly. 1994 Signals and signs for lymphocyte activation. Cell 76:275.
3. Marrack, P., and J. Kappler. 1987. The T cell receptor. Science 238:1073.
4. + precursor T cells by ligation of the antigen receptor. Nature 317:627.
5. Samelson, L. E., J. J. O'Shea, H. Luong, P. Ross, K B. Urdahl, R D. Klausner, and J. Bluestone. 1987. T cell antigen receptor phosphorylation induced by an anti-receptor antibody. J Immunol 139:2708.
6. Kappler, J. W., T. Wade, J. White, E Kushnir, M. Blackman, J. Bill, N. Roehm, and P. Marrack 1987. A T cell receptor vβ segment that imparts reactivity to a class II major histocompatibility complex product. Cell 49:263.
7. Gupta, K. L , A. K Ghosh, R. Kochhar, V. Jha, A. Chakrabarti, and V. Sakhuja. 1994. Esophageal candidiasis after renal transplantation: comparative study in patients on different immunosuppressive protocols Am J. Gastroenterol. 89: 1062
8. Grossi, P., L. Minoli, E. Percivalle, W. Irish, M Vigano, and G. Gerna. 1995. Clinical and virological monitoring of human cytomegalovirus infection in 294 heart transplant recipients. Transplantation 59:847
9. Wells, H. G., and T B. Osborne. 1911. The biological reactions of the vegetable proteins. I. Anaphylaxis. J. Infect Dis. 8.66.
10. Battisto, J. R., and J. Miller 1962. Immunological unresponsiveness produced m adult guinea pigs by parenteral introduction of minute quantities of hapten or protein antigen Proc. Soc. Exp. Biol. Med. 111:111.
11. Gutstein, N. L., W. E. Seaman, J. H. Scott, and D. Wofsy. 1986. Induction of immune tolerance by administration of monoclonal antibody to L3T4. J Immunol. 137:1127.
12. Benjamin, R. J., S. Qin, M. P. Wise, S P Cobbold, and H. Waldmann. 1988. Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination. Eur. J. Immunol. 18:1079.
13. + cells. J. Immunol. 140:713.
14. Isobe, M., H. Yagita, K. Okumura, and A. Ihara, 1992. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125.
15. Guerder, S., and P. Matzinger 1992. A fail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176:553.
16. Lancaster, F., Y. L. Chui, and J. R. Batchelor. 1985. Anti-idiotypic T cells suppress rejection of renal allografts in rats. Nature 315:336.
17. + T lymphocytes. J. Immunol. 142:748.
18. Qin, S., S. P Cobbold, H. Pope, J Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
19. Holan, V., and N A. Mitchison. 1983. Haplotype-specific suppressor T cells mediating linked suppression of immune responses elicited by third-party H-2 alloantigens. Eur. J. Immunol. 13:652.
20. Madsen, J. C., R. A, Superina, K. J. Wood, and P. J. Morris. 1988. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 332:161.
21. Cobbold, S. P., G. Martin, and H Wadmann. 1990. The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerised in the periphery with anti-CD4 and anti-CD8 antibodies. Eur. J Immunol. 20:2747.
22. Miller, A., O. Lider, and H. L. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:791.
23. Lombardi, C., S. Sidhu, R. Batchelor, and R Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587
24. Yeoman, H., and A L Mellor. 1992. Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells. Int. Immunol 4:59.
25. Weiss, E. H., L. Golden, K. Fahrner, A L Mellor, J. J. Devlin, H. Bullman, H Tiddens, H. Bud, and R. A. Flavell. 1984. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse Nature 310 650.
26. Cobbold, S. P., A Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
27. Qin, S., S. Cobbold, H. Tighe, R Benjamin, and H. Waldmann 1987 CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur. J. Immunol. 17:1159.
28. Qin, S., M. Wise, S. P Cobbold, L. Leong, Y. M. Kong, J. R Parnes, and H. Waldmann 1990. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur. J. Immunol. 20:2737.
29. Billingham, R. E., L. Brent, and P B. Medawar. 1953. "Actively acquired tolerance" of foreign cells. Nature 172:603.
30. Peto, R., M C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V Howard, N. Mantel, K. McPherson, J. Peto, and P. G. Smith. 1977. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II Analysis and examples. Br. J. Cancer 35.1.
31. Tomita, Y., and K. Nomoto. 1990. Induction of tolerance to non-H-2 alloantigens is not restricted by the MHC molecules expressed on the donor cells in cyclophosphamide-induced tolerance. Immunobiology 181:430.
32. Chen, Y., V. K Kuchroo, J. Inobe, D. A Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
33. Miller, A., O. Lider, A. B. Roberts, M. B. Sporn, and H L. Weiner. 1992. Suppressor T cells generated by oral tolerisation to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89:421.
34. Mosmann, T R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties Annu. Rev. Immunol. 7:145.
35. Swain, S. L., A. D Weinberg, M. Engish, and G Huston 1990. IL-4 directs the development of Th2-like helper effectors J. Immunol. 143:3796.
36. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Akins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123.115.
37. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent interferon-γ-independent mechanism. J. Exp Med. 171:115.
38. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627.
39. Dallman, M. J., C. P. Larsen, and P. J Morris. 1991, Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J. Exp. Med. 174:493.
40. Poo, W., L. Conrad, and C. A. Janeway. 1988. Receptor-directed focusing of lymphokine release by helper T cells. Nature 332:378.
41. Mitchison, N. A. 1971. The earner effect in the secondary response to hapten-protein conjugates. II Cellular cooperation. Eur. J. Immunol. 1.18.
42. b m B10. A(5R) mice. J. Exp. Med. 144:266.
43. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
44. Mitchison, N. A. 1990 An exact comparison between the efficiency of two- and three-cell-type clusters in mediating helper activity. Eur. J Immunol. 20:699.
45. Keene, J., and J. Forman. 1982. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes J Exp Med. 155:768.
46. Mitchison, N. A , and C. O'Malley. 1987. Three-cee-type clusters of T cells with antigen-presenting cells best explains the epitope linkage and noncognate requirements of the in vivo cytolytic response Eur. J. Immunol 17:2579.