Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: Implications for anti-CD154 immunotherapy

Journal of Immunology

Volumn 169, Issue 10, 2002, Pages 5401-5404

  Van Maurik, Andre ^a   Herber, Manuela ^a   Wood, Kathryn J ^a   Jones, Nick D ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TRANSPLANTATION; T LYMPHOCYTE;

EID: 0037111521     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.10.5401     Document Type: Article

References (18)

1. Parker, D. C., D. L. Greiner, N. E. Phillips, M. C. Appel, A. W. Steele, F. H. Durie. R. J. Noelle, J. P. Mordes, and A. A. Rossini. 1995. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc. Natl. Acad. Sci. USA 92:9560.
2. Larsen, C. P., E. T. Elwood, D. Z. Alexander, S. C. Ritchie, R. Hendrix, C. Tucker-Burden. H. R. Cho, A. Aruffo, D. Hollenbaugh, P. S. Linsley, et al. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434.
3. Kirk, A. D., D. M. Harlan, N. N. Armstrong, T. A. Davis, Y. Dong, G. S. Gray, X. Hong, D. Thomas, J. H. J. Fechner, and S. J. Knechtle. 1997. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. USA 94:8789.
4. + T cells can trigger allograft rejection. J. Immunol. 165:1111.
5. + T cells play a critical role in costimulation blockade-resistant allograft rejection. J. Clin. Invest. 104:1715.
6. + T cell tolerance and linked suppression. J. Immunol. 163:4805.
7. Williams, M. A., J. Trambley, J. Ha, A. B. Adams, M. M. Durham, P. Rees, S. R. Cowan, T. C. Pearson, and C. P. Larsen. 2000. Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts. J. Immunol. 165:6849.
8. Iwakoshi. N. N., T. G. Markees, N. Turgeon, T. Thornley, A. Cuthbert, J. Leif, N. E. Phillips, J. P. Morales, D. L. Greiner, and A. A. Rossini. 2001. Skin allograft maintenance in a new synchimeric model system of tolerance. J. Immunol. 167: 6623.
9. + T cells, interferon-γ and CTLA4. J. Clin. Invest. 101:2446.
10. Graca, L., K. Honey, E. Adams, S. P. Cobbold, and H. Waldmann. 2000. Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J. Immunol. 165:4783.
11. Niimi, M., N. Shirasugi, Y. Ikeda, S. Kan, H. Takami, and K. Hamano. 2001. Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathway. Transplantation 72:1556.
12. Sponaas. A. M., P. D. Tomlinson, J. Antoniou, N. Auphan, C. Langlet, B. Malissen, A. M. Schmitt-Verhulst, and A. L. Mellor. 1994. Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or β-globulin gene promoters. Int. Immunol. 6:227.
13. Corry, R. J., H. J. Winn, and P. S. Russell. 1973. Primarily vascularized allografts of hearts in mice: The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 16:343.
14. Peto, R., P. C. Pik, P. Armitage, D. R. Cox, S. V. Howard, N. Mantal. K. M. Pherson, J. Peto, and D. G. Smith. 1977. Design and analysis of randomised clinical trials which require prolonged observation of each patient. II Analysis and examples. Br. J. Cancer 35:1.
15. Jones, N. D., A. van Maurik, M. Hara, B. J. Gilot, P. J. Morris, and K. J. Wood. 1999. T-cell activation, proliferation, and memory after cardiac transplantation in vivo. Ann. Surg. 229:570.
16. Jones, N. D., S. E. Turvey, A. van Maurik, M. Hara, C. I. Kingsley, C. H. Smith, A. L. Mellor, P. J. Morris, and K. J. Wood. 2001. Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. J. Immunol. 166:2824.
17. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
18. + T cells. Proc. Natl. Acad. Sci. USA 99:8832.