Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen: Peripheral mechanisms do not contribute to maintenance of tolerance

Transplantation

Volumn 62, Issue 3, 1996, Pages 380-387

  Khan, Abrar ^a,b   Tomita, Yukihiro ^a,c   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY;

EID: 0029817245     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199608150-00014     Document Type: Article

References (44)

1. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273.
2. Webb S, Morris C, Sprent J. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 1990; 63: 1249.
3. Burkly LC, Lo D, Kanagawa O, Brinster RL, Flavell RA. T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature 1989; 342: 564.
4. Qin S, Cobbold SP, Pope H, et al. "Infectious" transplantation tolerance. Science 1993; 259: 974.
5. Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH. Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med 1985; 162: 231.
6. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J Exp Med 1989; 169: 493.
7. Acha-Orbea H, Palmer E. Mls-a retrovirus exploits the immune system. Immunol Today 1991; 12: 356.
8. + T cells. Immunogenetics 1991; 33: 157.
9. Dyson PJ, Knight AM, Fairchild S, Simpson E, Tomonari K. Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes. Nature 1991; 349: 531.
10. Bill J, Kanagawa O, Woodland D, Palmer E. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11 bearing T cells. J Exp Med 1989; 169: 1405.
11. + mouse T cell-clone. Immunogenetics 1988; 28: 445.
12. Tomita Y, Khan A, Sykes M. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J Immunol 1994; 153: 1087.
13. Sharabi Y, Abraham VS, Sykes M, Sachs DH. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191.
14. Dialynas DP, Quan ZS, Wall KA, et al. Characterization of murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to human Leu3/T4 molecule. J Immunol 1983; 131: 2445.
15. Sarmiento M, Glasebrook AL, Fitch FW. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 1980; 125: 2665.
16. Tomita Y, Sachs DH, Sykes M. Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 1994; 83: 939.
17. d antigens on the surface of these cells. Transplantation 1982; 34: 113.
18. Unkeless JC. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 1979; 150: 580.
19. b antibodies detect serological differences between H-2Kb mutants. Immunogenetics 1981; 12: 183.
20. Muller-Rucholtz W, Muller-Hermelink HK, Wottge HU. Induction of lasting hematopoietic chimerism in a xenogeneic (rat → mouse) model. Transplant Proc 1979; 11: 517.
21. + T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mis-disparate antigens. J Exp Med 1990; 171: 97.
22. d antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J Immunol 1980; 125: 2473.
23. Lee LA, Sergio JJ, Sykes M. Natural killer cells weakly resist engraftment of allogeneic long-term multilineage-repopulating hematopoietic stem cells. Transplantation 1996; 61: 125.
24. Roser BJ. Cellular mechanisms in neonatal and adult tolerance. Immunol Rev 1989; 107: 179.
25. Tutschka PJ, Ki PF, Beschorner WE, Hess AD, Santos GW. Suppressor cells in transplantation tolerance. II. Maturation of suppressor cells in the bone marrow chimera. Transplantation 1981; 32: 321.
26. Maki T, Gottshalk R, Wood ML, Monaco AP. Specific unresponsiveness to skin allografts in anti-lymphocyte serum-treated, marrow-injected mice: participation of donor marrow-derived suppressor T cells. J Immunol 1981; 127: 1433.
27. Morecki S, Leshem B, Weigensberg M, Bar S, Slavin S. Functional clonal deletion versus active suppression in transplantation tolerance induced by total lymphoid irradiation. Transplantation 1985; 40; 201.
28. Ramsdell F, Fowlkes BJ. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 1990; 248: 1342.
29. Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994; 24: 2383.
30. Morecki S, Leshem B, Eid A, Slavin S. Alloantigen persistence in induction and maintenance of transplantation tolerance. J Exp Med 1987; 165: 1468.
31. Rocha B, Tanchot C, Von Boehmer H. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J Exp Med 1993; 177: 1517.
32. Ramsdell F, Fowlkes BJ. Maintenance of in vivo tolerance by persistence of antigen. Science 1992; 257: 1130.
33. Sprent J. T lymphocytes and the thymus. In: Paul WE, ed. Fundamental immunology, 3rd ed. New York: Raven, 1993: 75.
34. Ramseier H. Immunization against abolition of transplantation tolerance. Eur J Immunol 1973; 3: 156.
35. Silvers WK. Studies on the apparent serial passage of transplantation immunity in tolerant mice. Transplantation 1970; 10: 538.
36. Billingham RE, Brent L, Medawar PB. Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Philos Trans R Soc 1955; 239 (Ser. B): 44.
37. Dorsch S, Roser B. T cells mediate transplantation tolerance. Nature 1975; 2580: 233.
38. Matriano JA, Socarras S, Streilein JW. Cellular mechanisms that maintain neonatally-induced tolerance of class 11 alloantigens. J Immunol 1994; 153: 1505.
39. Sykes M, Sheard MA, Sachs DH. Effects of T cell depletion in radiation bone marrow chimeras II. Requirement for allogeneic T cells in the reconstituting bone marrow inoculum for subsequent resistance to breaking of tolerance. J Exp Med 1988; 168: 661.
40. Korngold R, Sprent J. Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. J Exp Med 1978; 148: 1687.
41. Salaun J, Bandeira A, Khazaal I, et al. Transplantation tolerance is unrelated to superantigen-dependent deletion and anergy. Proc Natl Acad Sci USA 1992; 89: 10420.
42. Rocken M, Urban JF, Shevach EM. Infection breaks T-cell tolerance. Nature 1992; 359: 79.
43. Ohashi PS, Oehen S, Buerki K, et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991; 65: 305.
44. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256.