Alloantigen-induced specific immunological unresponsiveness

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 356, Issue 1409, 2001, Pages 665-680

  Wood, K J ^a   Jones, N D ^a   Bushell, A R ^a   Morris, P J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alloantigen; Immune tolerance; Mechanisms; Transplantation

Indexed keywords

EID: 0035967467     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2001.0840     Document Type: Review

References (178)

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6. Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients
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10. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
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13. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
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15. + T cell-mediated graft-versus-host disease
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34. Ability of 3M KCI-extracted histocompatibility antigen to potentiate the immunosuppressive effect of cyclosporine to prolong the survival of heterotopic rat cardiac allografts
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38. Pretreatment with viable and non-viable hepatocytes or liver membrane extracts produces indefinite renal allograft survival in the rat
39. Comparison of the effect of protein micelles containing purified class I MHC antigen and a cytotsolic preparation containing water soluble class I molecules on rat renal allograft survival
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41. + T cell subset that inhibits this autoimmune potential
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43. + cells regulate CD8 cell anergy in neonatal tolerance
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46. A molecules
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51. + suppressor T cells that are not dependent upon IL-4
52. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for the maintenance of tolerance to alloantigen in anti-CD4 treated recipients
53. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation
54. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
55. Allogeneic platelets increase survival of rat renal allografts
56. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
57. Suppressor T cells in allogeneic models
58. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
59. Positive selection of thymocytes
60. The effect of prior administration of donor strain blood or blood constituents on the survival of cardiac allografts in rats
61. Deletion of alloantigen-reactive thymocytes as a mechanism of adult transplantation tolerance induction following intrathymic antigen administration
62. The induction of transplantation tolerance by intrathymic delivery of alloantigen: A critical relationship between intrathymic deletion, export of new T cells and the timing of transplantation
63. Differential susceptibility of heart, skin and islet allografts to T cell mediated rejection
64. Graft-infiltrating T helper cells, CD45RC phenotype, and Th1/Th2-related cytokines in donor-specific transfusion induced in adult rats
65. A critical role for transforming growth factor beta in donor transfusion induced allograft tolerance
66. Reversal of transplantation immunity by liver grafting
67. Immunological function of a defined T-cell population tolerized to low-affinity self antigens
68. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys
69. Visualisation of peptide-specific T cell immunity and peripheral tolerance induction in vivo
70. Prolonged cardiac allograft survival following portal venous inoculation of allogeneic cells. What is hepatic tolerance?
71. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen
72. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain
73. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
74. Treatment with humanised monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
75. FN18-CRM9 immunotoxin promotes tolerance in primal renal allografts
76. The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat
77. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
78. Immunology of tissue transplantation: A return to the passenger leukocyte concept
79. Effect of one-HLA-DR antigen matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts
80. Regulatory mechanisms in the immune response to cell surface antigens
81. Licence to kill
82. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
83. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig
84. T suppressor lymphocytes inhibit NF-kappa B mediated transcription of CD86 gene in APC
85. Blocking both signal 1 and signal 2 of T cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
86. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
87. Anergic T cells as suppressor cells in vitro
88. The effect of anti-L3T4 monoclonal antibody on first-set rejection of murine cardiac allografts
89. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes
90. Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regime
91. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand
92. Deletion of donor-reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cells
93. Control of immune pathology by regulatory T cells
94. Immunological tolerance: The phenomenon of tolerance provides a testing ground for theories of the immune response
95. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
96. Studies on heterologous anti-lymphocyte serum in mice. III. Immunologic tolerance and chimerism produced across the H-2 locus with adult thymectomy and anti-lymphocyte serum
97. Interleukin-10
98. Leucocyte antigens in renal transplantation. The paradox of blood transfusion in renal transplantation
99. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy
100. Total lymphoid irradiation and transplantation tolerance
101. The importance of H2 haplotype sharing in the induction of specific unresponsiveness by pretransplant blood transfusions
102. Non-depleting anti-CD4 antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts
103. Induction of transplantation tolerance to rat cardiac allografts by intrathymic inoculation of allogeneic soluble peptides
104. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression
105. Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients
106. The role of HLA matching and blood transfusions in the cyclosporine era
107. Efficacy of rejection prophylaxis with OKT3 in renal transplantation
108. Effect of blood transfusions on subsequent kidney transplants
109. Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients
110. Immunogenetic consequences of vascular anastomoses between bovine twins
111. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. VI. In vitro alloreactivity of T cell subsets from rats with long-surviving allografts
112. Induction of transplantation tolerance in the adult using donor antigen and anti-CD4 monoclonal antibody
113. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model
114. CTLA4-Ig plus bone marrow induces long-term allograft survival and donor-specific unresponsiveness in the murine model
115. Induction of donor-specific unresponsiveness by intrathymic islet transplantation
116. The value of platelet transfusions as preparation for kidney transplantation
117. low subset
118. + T cells
119. Systemic administration of celkdar interleukin-10 can exacerbate cardiac allograft rejection in mice
120. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction
121. Induction of classical transplantation tolerance in the adult
122. 'Infectious' transplantation tolerance
123. +) T cell
124. Transfusion induces blood donor-specific suppressor cells
125. + regulatory cells that control intestinal inflammation
126. Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplanation
127. + T-helper and a T-killer cell
128. Coronary atherosclerosis in transplanted mouse hearts. I. Time course, immunogenetic and immunopathological considerations
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130. + T cells in the induction of tolerance to class I molecules
131. Immunologic self tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self tolerance causes various autoimmune diseases
132. Four year experience with donor-specific blood transfusions
133. Immunologic tolerance to renal allografts after bone marrow transplants from the same donors
134. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
135. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients
136. A cell culture model for T lymphocyte clonal anergy
137. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
138. Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells
139. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen
140. Islet allograft survival after a single course of treatment of recipient with antibody to L3T4
141. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy
142. Indirect presentation of MHC antigens in transplantation
143. Genetics of the blood transfusion effect on heart allografts in rats
144. Bulk purification of a naturally occurring soluble form of RT1A class I major histocompatibility antigens from DA rat liver and studies of specific immunosuppression
145. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lympho-hematopoietic chimerism
146. - subpopulations
147. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene
148. Mixed lymphohe-matopoietic chimerism and graft vs lymphoma effects are achievable in adult humans following non-myeloablative therapy and HLA-mismatched donor bone marrow transplantation
149. Anergic T cells actively suppress T cell responses via the antigen presenting cell
150. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
151. + regulatory T cells constitutively expressing cytotoxic T lymphocyte associated antigen 4
152. Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression
153. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen
154. Modulation of the T cell compartment by blood transfusion
155. Blood transfusions induce prolong kidney graft survival in rhesus monkeys
156. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
157. Pretransplantation blood transfusion revisited
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159. Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
160. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
161. Mixed chimerism as an approach for the induction of transplantation tolerance
162. Requirement for T cell apoptosis in the induction of peripheral transplantation tolerance
163. The immune response to allogeneic rat platelets (Ag-B) antigens in matrix form lacking Ia
164. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta
165. Linked suppression of skin graft rejection can operate through indirect recognition
166. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: Studies with soluble antigens in intact mice
167. Syngeneic bone marrow expressing a single donor class I MHC molecule permits acceptance of a fully allogeneic cardiac allograft
168. Pretransplant administration of a single donor class I MHC molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: Evidence for linked epitope suppression
169. Retroviral gene transfer of a donor class I MHC gene to recipient bone marrow cells induces tolerances to alloantigens in vivo
170. Suppressor cells in specific unresponsiveness to skin allografts in ALS-treated, marrow-injected mice
171. Induction of unresponsiveness to skin allografts in adult mice disparate at defined regions of the H-2 complex. II. Effect of donor-specific bone marrow in ALS-treated mice
172. The blood transfusion effect: Suppression of renal allograft rejection in the rat using purified blood components
173. Chimerism and transplantation tolerance: Cause and effect
174. + CD4 T cell subsets are maintained in an unresponsive state by the persistence of transfusion-derived alloantigen
175. Mechanisms of tolerance following class II gene transduction of autologous swine bone marrow
176. Effect of one-HLA-haplotype-matched and HLA-mismatched blood transfusions on recipient T lymphocyte allorepertoires
177. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression