Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Journal of Pharmaceutical Sciences

Volumn 90, Issue 4, 2001, Pages 436-447

  Poulin, Patrick ^a   Schoenlein, Kerstin ^a   Theil, Frank Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Drug discovery; Partition coefficients; PBPK modeling; Physiologically based pharmacokinetics; QSAR

Indexed keywords

DIAZEPAM; EPIROPRIM; IMIPRAMINE; IODOPHENAZONE; LIPID; MEFLOQUINE; METHOHEXITAL; NICOTINE; NITRAZEPAM; OCTANOL; OLIVE OIL; ORGANIC SOLVENT; PENTAZOCINE; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PLASMA PROTEIN; PROCAINE; THIOBARBITAL; THIOPENTAL; WATER;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; HUMAN; HUMAN TISSUE; LIPOPHILICITY; MACROMOLECULE; MALE; NONHUMAN; PARTITION COEFFICIENT; PLASMA; POLLUTANT; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; TISSUE DISTRIBUTION;

EID: 0035044107     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200104)90:4<436::AID-JPS1002>3.0.CO;2-P     Document Type: Article

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