Toward a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of HERG K+ channel blockers

Journal of Medicinal Chemistry

Volumn 45, Issue 18, 2002, Pages 3844-3853

  Cavalli, Andrea ^a   Poluzzi, Elisabetta ^a   De Ponti, Fabrizio ^a   Recanatini, Maurizio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; AMITRIPTYLINE; ASTEMIZOLE; AZIMILIDE; BEPRIDIL; CHLORPROMAZINE; CISAPRIDE; DILTIAZEM; DOFETILIDE; DOLASETRON MESILATE; DOMPERIDONE; DROPERIDOL; GRANISETRON; GREPAFLOXACIN; HALOFANTRINE; HALOPERIDOL; IMIPRAMINE; LORATADINE; MIBEFRADIL; MIZOLASTINE; PERHEXILINE; PIMOZIDE; POTASSIUM CHANNEL BLOCKING AGENT; SERTINDOLE; SILDENAFIL; SPARFLOXACIN; TERFENADINE; THIORIDAZINE; UNINDEXED DRUG; VERAPAMIL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; DRUG POTENCY; HUMAN; HUMAN CELL; LONG QT SYNDROME; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR BLOCKING; SCREENING; STEREOCHEMISTRY;

ANTI-ARRHYTHMIA AGENTS; CATION TRANSPORT PROTEINS; CLUSTER ANALYSIS; DATABASES, FACTUAL; ETHER-A-GO-GO POTASSIUM CHANNELS; LONG QT SYNDROME; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037194634     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0208875     Document Type: Article

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