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Volumn 15, Issue 3, 2001, Pages 273-286
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Lipophilicity in PK design: Methyl, ethyl, futile
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Author keywords
Calcium channel antagonists; Clearance; Hydrophobicity; Lipophilicity; P glycoprotein; P450 metabolism; Plasma protein binding; Renin inhibitors; Volume of distribution; Adrenoceptor antagonists
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Indexed keywords
ALCOHOLS;
BIOCHEMISTRY;
CALCIUM;
DRUG DELIVERY;
GLYCOPROTEINS;
HYDROGEN;
HYDROGEN BONDS;
PHARMACOKINETICS;
PHYSIOLOGY;
PROTEINS;
CALCIUM CHANNEL ANTAGONISTS;
CLEARANCE;
LIPOPHILICITY;
ORAL ABSORPTION;
P-GLYCOPROTEIN;
P450 METABOLISM;
PLASMA PROTEIN BINDING;
RENIN INHIBITOR;
VOLUME OF DISTRIBUTION;
Β-ADRENOCEPTOR ANTAGONIST;
METABOLISM;
ALPRENOLOL;
AMLODIPINE;
ANSECULIN;
ATENOLOL;
BETA ADRENERGIC RECEPTOR BLOCKING AGENT;
BETAXOLOL;
BISOPROLOL;
CARVEDILOL;
CENTRAL NERVOUS SYSTEM AGENTS;
CHOLINESTERASE INHIBITOR;
CYTOCHROME P450;
CYTOCHROME P450 3A4;
DESIPRAMINE;
DOPAMINE 2 RECEPTOR BLOCKING AGENT;
DRUG METABOLIZING ENZYME;
GLYCOPROTEIN P;
HALOPERIDOL;
METOPROLOL;
NADOLOL;
NIFEDIPINE;
OCTANOL;
OXPRENOLOL;
PLASMA PROTEIN;
PROPRANOLOL;
REMOXIPRIDE;
SULPIRIDE;
TALINOLOL;
THIORIDAZINE;
UNINDEXED DRUG;
WATER;
ARTICLE;
BRAIN;
COMPUTER AIDED DESIGN;
CONTROLLED STUDY;
DIFFUSION COEFFICIENT;
DRUG ABSORPTION;
DRUG CLEARANCE;
DRUG DISTRIBUTION;
DRUG POTENCY;
DRUG SOLUBILITY;
DRUG STRUCTURE;
DRUG UPTAKE;
ENZYME METABOLISM;
GASTROINTESTINAL ABSORPTION;
HUMAN;
HYDROGEN BOND;
LIPOPHILICITY;
MEMBRANE PERMEABILITY;
MOLECULAR SIZE;
MOLECULAR WEIGHT;
PHYSICAL CHEMISTRY;
PLASMA PROTEIN BINDING;
PRIORITY JOURNAL;
QUANTITATIVE STRUCTURE ACTIVITY RELATION;
STRUCTURE ANALYSIS;
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EID: 0035106611
PISSN: 0920654X
EISSN: None
Source Type: Journal
DOI: 10.1023/A:1008192010023 Document Type: Article |
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Times cited : (233)
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References (39)
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