Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 304-311

  Mandagere, Arun K ^a   Thompson, Thomas N ^b   Hwang, Kin Kai ^c  

^a PFIZER INC   (United States)

^b IQVIA   (United States)

^c SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; INDOMETACIN; LIVER ENZYME; MANNITOL; METOPROLOL; PROPRANOLOL; TIMOLOL; VERAPAMIL;

ACIDITY; ALKALINITY; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG PENETRATION; GUINEA PIG; HUMAN; HUMAN EXPERIMENT; NONHUMAN; NORMAL HUMAN; RAT; SPECIES COMPARISON;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; DOGS; GUINEA PIGS; HUMANS; LIVER; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS; RATS; SPECIES SPECIFICITY;

EID: 0037122748     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010152k     Document Type: Article

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