Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors

Journal of Drug Targeting

Volumn 6, Issue 2, 1998, Pages 151-165

  Van De Waterbeemd, Han ^a,e   Camenisch, Gian ^a   Folkers, Gerd ^b   Chretien, Jacques R ^c   Raevsky, Oleg A ^d  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITÉ D'ORLÉANS   (France)

^d INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

BBB uptake estimation; Brain drug delivery; Lipophilicity; Molecular shape; Molecular weight; Partition coefficients

Indexed keywords

ARTICLE; BLOOD BRAIN BARRIER; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TARGETING; DRUG TRANSPORT; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR SIZE; MOLECULAR WEIGHT; PERMEABILITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

EID: 0032410164     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808997889     Document Type: Article

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